Effects of exposure to high levels of particulate air pollution during the follicular phase of the conception cycle on pregnancy outcome in couples undergoing in vitro fertilization and embryo transfer

Department of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil.
Fertility and sterility (Impact Factor: 4.59). 07/2009; 93(1):301-3. DOI: 10.1016/j.fertnstert.2009.06.031
Source: PubMed


The objective of this retrospective cohort study was to assess the potential effects of preconceptional short-term exposure to particulate air pollution in a real-world situation on pregnancy outcome in infertile women evaluating the possible role of IVF/embryo transfer treatment on this outcome using women who had conceived naturally for the first time during the same time frame as a matched control group. The study provides evidence for an association between brief exposure to high levels of ambient particulate matter (aerodynamic diameter <or=10 microm) during the preconceptional period and early pregnancy loss, regardless of the method of conception, and showed a 2.6-fold increase in risk of miscarriage, suggesting a threshold instead of a monotonic effect of this exposure on reproductive outcome.

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    • "Previous studies have shown that environmental tobacco smoke is associated with an increased risk of spontaneous abortion [19-21]. One retrospective epidemiological study provided evidence for an association between brief exposure to high levels of ambient particulate matter during the preconceptional period and early pregnancy loss and found a 2.6-fold increased risk of spontaneous miscarriage [22]. More recent investigations in China [23] and Iran [24] also reported an increased risk of fetal loss in early pregnancy during exposure to high levels of air pollutants. "
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