Emerging mechanisms of vascular stabilization

Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Journal of Thrombosis and Haemostasis (Impact Factor: 5.72). 08/2009; 7 Suppl 1(s1):57-60. DOI: 10.1111/j.1538-7836.2009.03421.x
Source: PubMed


Neural guidance cues are essential for a growing axon to correctly course through the body and innervate target tissues. Interestingly, the vascular network follows a parallel trajectory along nerves, suggesting that guidance cues important for neural patterning may also be required for proper vascular patterning. However, while an axon arises from one cell, a blood vessel is composed of many endothelial cells. Recent evidence suggests that neural repulsive cues are usurped by multi-cellular blood vessels to ensure vascular stabilization cues. Additional clues into the signaling mechanisms that promote vascular stabilization are emerging from cerebral cavernous malformations, a disease characterized by headache, epilepsy, and stroke. Thus, neurobiology and neurology are providing insights into the concepts of vascular stability.

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