No full-text available
To read the full-text of this research,
you can request a copy directly from the author.
... While CNS toxicity often presents with the above initial features, seizures are the most common consequence. Additionally, in the setting of intravascular injection seizures can be the initial presentation [5]. Cardiovascular toxicity manifests by hypotension, atrioventricular heart block, idioventricular rhythms, and life-threatening arrhythmias such as ventricular tachycardia and fibrillation [6]. ...
... Cardiovascular toxicity manifests by hypotension, atrioventricular heart block, idioventricular rhythms, and life-threatening arrhythmias such as ventricular tachycardia and fibrillation [6]. Central nervous system toxicity usually precedes the cardiovascular effects as it occurs at a lower plasma concentration [5]. Seizures activity ceases rapidly and ultimately is followed by respiratory depression and can proceed to respiratory arrest. ...
We present a previously normal 11 years old girl with a generalized weakness and coma following convulsive status epilepticus which developed after inferior alveolar nerve blockade through local lidocaine injection by a dentist. The patient was admitted to the pediatric intensive care unit and recovered within several days.
... Many minor events probably go unnoticed and unreported. Since the 80s, major events have decreased secondary to recognition and preventive measures [3]. Despite the low incidence, there is potential for severe toxicity. ...
Local anesthetics are widely used by various medical professionals. Although their usefulness is unquestionable, as with any medication, there is a possibility of iatrogenic effects. When local anesthetic systemic toxicity occurs, it might be a life-threatening condition. Knowing its existence and how to act when it arises is crucial. The clinical presentation is wide-ranging, but globally it affects the neurological and cardiovascular system, with cardiac arrest being the extreme of its presentation. The treatment is mainly supportive with an attempt to reverse the effects of the anesthetic by administering a lipid emulsion. Here, we present a clinical case of difficult management with many complications.
Local anesthetics are commonly used in the perioperative environment to facilitate surgical procedures or to provide postoperative pain management for patients. The use of local anesthetics, however, introduces the risk of complications resulting from local anesthetic systemic toxicity and the risks of increased morbidity and mortality for the surgical patient. Systemic toxicity from the injection or overdose of local anesthetics is a rare but potentially fatal complication that occurs in less than 1 in 1,000 patients. This article provides the perioperative nurse with information about local anesthetics, the signs and symptoms of local anesthetic systemic toxicity, and the information needed to manage a patient experiencing this complication.
The topical anaesthesia of the pharynx before upper digestive endoscopies is usually performed by most of the endoscopists in view to improve comfort and quality of the examination.
Until now, no study have assessed the usefulness of this practice.
Moreover it can involve potentially serious undesirable effects that we re-examine in detail, in the light of the pharmacological data.
We compare the topical anaesthetic drugs usually employed and propose recommendations in order to prevent and to treat the complications.
A case of a 2-year-old girl who survived grand mal seizures secondary to toxicity from massive subcutaneous administration of lidocaine is presented. She was treated with intravenous diazepam and was intubated. After 24 hours of observation she was discharged, and there have been no sequelae or recurrence of seizure activity during ten months follow up. Central nervous system, cardiac, and hematologic effects of lidocaine toxicity are discussed. Drug interactions that may potentiate lidocaine toxicity are listed.
ResearchGate has not been able to resolve any references for this publication.