Conference Paper

Assessment of the Effect of Essential Oils on Induced Bacteremia

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Objective: The purpose of this IRB approved, double-blind, placebo-controlled, randomized, cross-over study was to assess the effect of twice daily rinsing with an essential oil mouthrinse (EOM) in reducing bloodstream bacteria after inducing a standardized bacteremic challenge. Methods: Ninety-eight individuals with moderate gingivitis were screened, instructed to chew an apple, and had blood drawn to assess their susceptibility to a bacteremia. Thirty subjects were bacteremia positive and were instructed to brush with a fluoride dentifrice for 2-weeks to normalize oral hygiene after which they reported to the clinic for a baseline exam which consisted of plaque collection and chewing an apple to assess induced bacteremia as previously. At Baseline, subjects were randomly assigned to either EOM or a control treatment and instructed to rinse twice daily for 2 weeks. After 2 weeks, subjects returned to the clinic to have plaque collection and assessment of induced bacteremia. Subjects then brushed with a fluoride dentifrice during a 2-week wash-out period and returned to the clinical site to receive the same procedures performed in the first baseline examination. Subjects were crossed-over to the alternate treatment group, and returned two-weeks later to repeat procedures performed at previous visits. Differences in bacterial counts between baseline and 2-week post-treatment (EOM vs. Control) in blood-borne bacteria were assessed by ANCOVA. Results: In the EOM treatment group, the induced bacteremia was decreased by 13.5 CFU/mL from baseline for total aerobic bacteria (64.1% decrease; p< 0.001) and by 10.1 CFU/mL for total anaerobic bacteria (65.2% decrease; p <0.001). Control treatment showed no reduction for induced bacteremia. Plaque bacteria were also significantly reduced in the EOM group. Conclusions: The germ killing action of an essential oil containing mouthrinse reduced the level of bacteria in the bloodstream and dental plaque in subjects with moderate gingivitis following 2-weeks of use.

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... This placebo-controlled, randomized, double-blinded, 2-week cross-over study showed that the use of an EOM reduced the amount of blood-borne bacteria resulting from chewing an apple in a susceptible group of subjects that had mild-to-moderate gingivitis. This study has been submitted as an abstract to American Heart Association (AHA) annual convention November 2010 (21). ...
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