Efficacy of Orally Administered Superfine Dispersed Lentinan (β-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer

Department of Surgery II, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.
Anticancer research (Impact Factor: 1.83). 07/2009; 29(7):2611-7.
Source: PubMed


Lentinan (LNT) is an immune adjuvant medicine for advanced gastric cancer in Japan. Recently, an oral formulation of superfine dispersed lentinan (SDL) has become clinically available. To investigate the safety and effectiveness of SDL, a multi center clinical study in patients with advanced colorectal cancer was conducted.
Adverse events were assessed and the patients' quality of life (QOL) and the binding ability of peripheral blood monocytes (PBM) to LNT were also evaluated.
Four grade 2 adverse events associated with SDL treatment were observed among the 80 patients. Adverse events associated with chemotherapy were observed in 9 out of the 64 chemotherapy-treated patients. Among the 48 patients assessed for QOL, the patients with low QOL scores before SDL treatment (n=23) reported a significant improvement in their QOL scores after 12 weeks of SDL administration. The rates of LNT-binding PBM in the QOL-improved group were significantly higher than those in the QOL-not-improved group (p<0.05).
SDL was safe and effective for suppressing the adverse effects of chemotherapy as well as improving QOL. The binding ability of PBM to LNT appears to be a promising predictor of QOL improvement after SDL administration.

Download full-text


Available from: Yasuyo Suga, Aug 25, 2015
  • Source
    • "2009) and colorectal cancer (Hazama et al. 2009). Nakano et al. "
    [Show abstract] [Hide abstract]
    ABSTRACT: This randomized, placebo-controlled, double-blind study compared the effects of daily supplementation for 4 week with 250 mg Wellmune WGP® β-1,3/1,6-Glucan (WGP) with placebo 250 mg/day (rice flour) on physical and psychological health attributes of self-described "moderate" ragweed allergy sufferers. Study participants (mean age = 36 ± 9 year; range 18-53 year) were recruited before the beginning of ragweed season (September) in Northeastern Ohio. Serum IgE concentration, allergy symptoms [via self-report, Visual Analog Scale (VAS), and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)], psychological well-being [Profile of Mood States (POMS)], and physical function (RAND SF-36 Medical Outcomes Study) were measured immediately prior to and after supplementation with WGP (n = 24) or placebo (n = 24) for 4 weeks. Data were analyzed using repeated measures analyses of variance (ANOVA). Compared with placebo, WGP reduced total allergy symptoms (28%), symptom severity (52%), and symptom rating on the VAS (37%) (P < 0.05), but had no effect on serum IgE levels. As measured by the POMS, WGP increased participants' rating of vigor (10%), but reduced tension (34%), depression (45%), anger (41%), fatigue (38%), and confusion (34%) (P < 0.05). Study participants given WGP reported increased physical health (11%), energy (19%), and emotional well-being (7%) compared with study participants given the placebo (RAND SF-36 Medical Outcomes Study). The WGP group also reported decreased sleep problems (53%), reduced nasal symptoms (59%), eye symptoms (57%), non-nasal symptoms (50%), activities (53%), emotions (57%), and improved quality of life (QOL) (56%), as well as improved global mood state (13%). Supplementation with WGP for 4 weeks improved allergy symptoms, overall physical health, and emotional well-being compared with placebo in self-described "moderate" ragweed allergy sufferers during ragweed allergy season.
    Full-text · Article · Jan 2013 · Food Science & Nutrition
  • [Show abstract] [Hide abstract]
    ABSTRACT: Glucan sulfates with different degree of substitution were prepared from partially sulphated insoluble β-1, 3-D-glucan isolated from Saccharomyces cerevisiae cell wall. Sulphation was done with sulfate acid (H2SO4) in dimethyl sulfoxide (DMSO) in presence of urea. Varying reaction times, temperature and ratio of H2SO4 and DMSO were used to obtain glucan sulfates with distinct degree of substitution, which was measured by barium chloride-gelatin method. The immunoprophylaxis effect of glucan sulfates in a mouse model of Escherichia coli induced peritonitis was studied and found to be related to the degree of substitution. The result showed that as the degree of substitution increased, the immunoprophylaxis efficacy increased.
    No preview · Article · Jan 2010
  • [Show abstract] [Hide abstract]
    ABSTRACT: The medicinal use of mushrooms, so-called higher fungi, has a very long tradition in the Asian countries, whereas their use in the Western hemisphere has been slightly increasing only since the last decades. The paper gives an overview about the most important medicinal mushrooms and summarizes the actual knowledge about chemistry and pharmacology of Lentinula edo-des (Shiitake, Golden Oak Mushroom), Ganoderma lucidum (Reishi, Ling Zhi), Agaricus brasiliensis (Royal sun agaricus), Grifola frondosa (Maitake, Hen-of-the-Woods) and Hericium erinaceus (Yamabushitake, Lion's Man, Monkey's Head).
    No preview · Article · Feb 2010 · Medizinische Monatsschrift für Pharmazeuten
Show more