Efficacy and safety of very-low-calorie diet in Taiwanese: A multicenter randomized, controlled trial

Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Nutrition (Impact Factor: 2.93). 07/2009; 25(11-12):1129-36. DOI: 10.1016/j.nut.2009.02.008
Source: PubMed


Very-low-calorie diets (VLCDs) are an effective method for weight reduction in Caucasians. This study investigated the efficacy and safety of two different VLCDs (450 or 800kcal/d) in obese Taiwanese.
132 participants with BMI > or =30kg/m(2) were randomized to two VLCD groups for body weight reduction for 12 weeks. Each group had 66 participants. Anthropometric and metabolic parameters were measured.
The intention-to-treat analysis revealed that the percentage change in body weight over the 12-week treatment period was -9.14% in the VLCD-450 group and -8.98% in the VLCD-800 group. A total of 27 (40.9%) participants in the VLCD-450 group and 29 (43.9%) participants in the VLCD-800 group achieved 10% or more weight loss at the end of treatment. The body weight, waist circumference, hip circumference, fat mass, blood pressure, triglycerides, and blood glucose were statistically improved from baseline but not between the two groups. The improvement rate of nonalcoholic fatty liver disease (NAFLD) was 41.5% in the VLCD-450 group and 50.0% in the VLCD-800 group. The incidence of adverse events did not differ significantly between the groups and no serious adverse events were reported in either group.
Both the VLCD-450 and 800kcal/d can effectively and safely reduce body weight and improve NAFLD in 12 weeks in obese Taiwanese participants. However, there is no additional benefit in prescribing the more restrictive diet intervention in Taiwanese.

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    • "In the medical literature, the length of time on these diets varied between 4 and 24 weeks (Wadden et al, 1983b), with initial weight losses of 1.4–2.5 kg per week and suggestions that the longer the period of calorie restriction the greater the weight loss (Saris, 2001); however, prolonged calorie restriction can potentially affect compliance in the long term. Despite the theoretical idea that VLEDs should produce greater weight loss because of greater energy restriction, this has not been shown to be the case over the long term (Saris, 2001; Norris et al, 2005; Lin et al, 2009; Christensen et al, 2011). In a metaanalysis of six randomised controlled trials, initial short-term weight loss was significantly greater following VLEDs compared to LEDs (16.1% vs. 9.7% of initial weight; Tsai and Wadden, 2006). "

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    • "One study [12] looked at the differences in ethnicity in response to a VLCD delivered with exercise and behavioural therapy. Also, the gender composition of the studies were quite different, as some studies looked at women only [12, 13], while the other studies all included men [14–16]. Weight loss was significant in all but the 2-day VLCD group [13]. "
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