β-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development

National Research Center for Mental Health RAMS, 113152 Moscow, Zagorodnoe shosse 2/2, Russia.
Peptides (Impact Factor: 2.62). 08/2009; 30(10):1854-60. DOI: 10.1016/j.peptides.2009.06.025
Source: PubMed


Casomorphins are the most important during the first year of life, when postnatal formation is most active and milk is the main source of both nutritive and biologically active material for infants. This study was conducted on a total of 90 infants, of which 37 were fed with breast milk and 53 were fed with formula containing cow milk. The study has firstly indicated substances with immunoreactivity of human (irHCM) and bovine (irBCM) beta-casomorphins-7 in blood plasma of naturally and artificially fed infants, respectively. irHCM and irBCM were detected both in the morning before feeding (basal level), and 3h after feeding. Elevation of irHCM and irBCM levels after feeding was detected mainly in infants in the first 3 months of life. Chromatographic characterization of the material with irBCM has demonstrated that it has the same molecular mass and polarity as synthetic bovine beta-casomorphin-7. The highest basal irHCM was observed in breast-fed infants with normal psychomotor development and muscle tone. In contrast, elevated basal irBCM was found in formula-fed infants showing delay in psychomotor development and heightened muscle tone. Among formula-fed infants with normal development, the rate of this parameter directly correlated to basal irBCM. The data indicate that breast feeding has an advantage over artificial feeding for infants' development during the first year of life and support the hypothesis for deterioration of bovine casomorphin elimination as a risk factor for delay in psychomotor development and other diseases such as autism.

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Available from: Oleg Yu Sokolov, Apr 30, 2015
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    • "However, several groups did not find these peptides [9] [10] using highly sophisticated techniques, much to our consternation. A Russian group serum levels of casomorphin 1-7 (bovine), which were negatively correlated to psychomotor development in children with psychomotoric problems [11] "

    Full-text · Article · Jan 2014 · Open Journal of Psychiatry
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    • "A Russian group (10) found that casomorphin in the blood was inversely related to psychomotor development in infants. Casomorphins have, furthermore, been shown to abrogate separation distress call and reaction in newly hatched chickens (22) and also causing social isolation in kittens and pups. "
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    • ", a shortage of proteolytic enzymes , immaturity of the mucous membrane and on - going shaping of the intestinal flora ( Lucas et al . , 1985 ; Weaver , 1992 ) . An immuno - reactive b - casomorphin material in blood sera of newborns ( in - fants , calves , and puppies ) after feeding them with cows ' milk have also been identified by the teams of Kost et al . ( 2009 ) , Singh et al . ( 1989 ) , and Umbach et al . ( 1985 ) ) . The amounts of bovine b - casomorphin - 7 identified by us were higher than the ones reported by Kost , Umbach and Singh . One of the explanations for the causes of those differences is the polymorphism of bovine b - casomorphin that has a significant influence on the possibil"
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