Study of the Comparative Efficacy of Toltrazuril and Diclazuril against Ovine Coccidiosis in Housed Lambs

Bayer Animal Health GmbH, Leverkusen, Germany.
Parasitology Research (Impact Factor: 2.1). 09/2009; 105 Suppl 1(S1):S141-50. DOI: 10.1007/s00436-009-1505-y
Source: PubMed


A blinded, controlled and randomised field study was conducted on a sheep farm with a known history of coccidiosis and a high prevalence mainly of the pathogenic coccidium Eimeria ovinoidalis. The efficacy of treatment with toltrazuril (Baycox 5% suspension) against natural infections with Eimeria crandallis and/or Eimeria ovinoidalis in housed lambs was investigated in comparison with diclazuril and untreated controls. Both drugs were administered either metaphylactically (i.e., in the prepatency of Eimeria spp.) or therapeutically (after onset of oocyst excretion). A total of 145 animals aged 1 to 5 days at the start of the study were included. Examination of faecal samples was performed every second day between days 13 and 49 of the study. The assessment of treatment efficacy was based mainly on total oocyst excretion and the number of E. crandallis and E. ovinoidalis oocysts (OPG) shed throughout the study. Oocyst excretion was reduced significantly in both groups treated with toltrazuril compared with the untreated control group and with both diclazuril-treated groups. The most prevalent and most severe diarrhoea was observed in the untreated control group. In this study, toltrazuril proved to be highly effective in controlling ovine coccidiosis both metaphylactically and therapeutically. The efficacy of toltrazuril was significantly higher than the efficacy of the control substance with regard to the duration and amount of oocyst excretion, both for the comparison of metaphylactic as well as therapeutic treatment.

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Available from: Arwid Daugschies, Feb 13, 2014
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    • "Nevertheless , a decrease of E. ahsata and partially of E. crandallis/weybridgensis oocysts after 2–4 weeks from toltrazuril treatment and of E. ahsata after 1–2 weeks from diclazuril treatment was observed, although less consistent compared with the data of Platzer et al. (2005). To note that the prevalence of some pathogenic species as E. ahsata and E. ovinoidalis declined both in treated groups and untreated lambs towards the end of the study, possibly due to the developing immunity (Greif, 2000; Mundt et al., 2009; Taylor et al., 2011) while E. bakuensis and E. crandallis/weybridgensis lasted practically unchanged. About the "
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    ABSTRACT: A field study was conducted to compare the effect of toltrazuril and diclazuril treatment against Eimeria infection in 142 naturally infected, weaned lambs aged 45-60 days. Lambs were divided into three groups of 48 and 48 animals and treated with toltrazuril (20 mg/kg b.w.) and diclazuril (1 mg/kg b.w.). The last group of 46 lambs was left untreated as control. Oocyst faecal counts (OPG), Eimeria species and faeces consistency where assessed weekly from day 7 to day 63. In comparison with the control group, the OPG reduction on day 7 and 14 in toltrazuril-treated lambs was 99.1% and 97.4%, respectively, and 67% and 58% in lambs treated with diclazuril (p < 0.005). On day 21, the percent of OPG reduction was still significant in toltrazuril-treated lambs (76.3%, p < 0.05). Treatment with toltrazuril showed a decrease of Eimeria ahsata and E. crandallis oocysts at the time of maximum efficacy. The same effect was found in the diclazuril-treated group for E. ahsata only. No difference was found between the three groups regarding the consistency of the faeces (p > 0.05). Body weight gains were determined at the start and the end of the study and showed a significant increase in the toltrazuril-treated lambs (p < 0.001). This results suggested a greater efficacy of toltrazuril against subclinical eimeriosis in weaned lambs.
    Full-text · Article · Aug 2014 · Small Ruminant Research
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    • ") and a morphometric identification of the species (Levine 1961) were carried out on samples of faeces collected individually beginning from the day of treatment (T 0 ) and subsequently once a week for the following 9 weeks (T 1 , T 2 , …T 9 ). In addition, for each week during the controls scheduled by the experimental protocol, "
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    ABSTRACT: Sheep coccidiosis is a pathology caused by protozoan parasites of the genus Eimeria spp. with clinical and economic effect especially in young animals (Ambrosi 1995; PellErdy 1974). A field study was conducted to evaluate the efficacy of a metaphylactic treatment with toltrazuril 5% suspension (Baycox (R), Bayer) in comparison with diclazuril (Vecoxan (R), Janssen-Cilag) and untreated controls against naturally acquired Eimeria infections in housed lambs. A total of 170 animals, aged 24 to 34 days and randomly divided in three homogeneous groups, were included in the study. The assessment of treatment efficacy was based on total faecal oocyst excretion (opg) and count reduction (FOCR) in the two groups of animals treated with toltrazuril (TOLT) and diclazuril (DICL) compared with untreated control group (C). The animals treated with toltrazuril showed a considerably lower mean opg to that of group C (5.78 opg versus 144.62 opg) (p < 0.05) and a FOCR of 97.7%. The higher efficacy (99.23%) was observed at 15 days post treatment; however, the average efficacy of the [GRAPHICS] . drug remained extremely high (>90%) for all the study. The lambs treated with diclazuril showed an intense, persistent oocyst excretion with average levels of 97.54 opg, ( p < 0.05). This study demonstrates the good efficacy of toltrazuril administered orally to lambs in the prepatent period in subclinical natural Eimeria infections in housed lambs.
    Full-text · Article · Jun 2013 · Parasitology Research
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    • "Toltrazuril and diclazuril have previously been applied and evaluated for this purpose (Gjerde and Helle, 1986, 1991; Taylor and Kenny, 1988; Le Sueur et al., 2009; Platzer et al., 2005; Mundt et al., 2009; Taylor et al., 2011). The majority of the studies dealing with the efficacy of chemical treatments have so far mainly focused on lamb fattening systems, either pasture or indoor based (Gjerde and Helle, 1986, 1991; Taylor and Kenny, 1988; Alzieu et al., 1999; Mundt et al., 2009; Taylor et al., 2011). The purpose of the present study was to determine the effects of chemical treatment against coccidiosis in lambs kept under dairy husbandry systems applied in the Southern Mediterranean region. "
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    ABSTRACT: The effect of different treatment protocols using the triazinone compounds diclazuril and toltrazuril on Eimeria oocyst excretion, diarrhoea and weight gain was evaluated in the present study. The protocols were designed in order to best fit to common management practices in dairy production systems as applied in Greece. During the first two trials comparative preventive (11 days after birth) and therapeutic (18 days after birth) single treatments using either drug were performed on an intensive farm. In Trial 3 the efficacy of a repeated diclazuril treatment after weaning (at the start and 4 weeks later) of the animals in a semi-intensive farm was tested. The last trial was performed in order to assess the effect of a single oral dose of toltrazuril after weaning of the animals on the same farm. During an observation period of 6-7 weeks after treatment animals in all trials were clinically examined for diarrhoea and faecal samples were regularly monitored for Eimeria oocysts at weekly intervals. Body weight was also determined at the start and end of each trial. A single treatment with toltrazuril resulted in a significant reduction of oocyst excretion over the study period compared to the control, with very high efficacy values during the first 2-3 weeks after treatment, irrespective of the treatment protocol and the management system applied. This in general could not be confirmed in the protocols using diclazuril, which showed a much lower and mostly variable efficacy pattern.
    Full-text · Article · Feb 2013 · Veterinary Parasitology
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