In the search for biochemical means to facilitate psychotherapy, a number of drugs have been used singly and in various combinations: psychedelics such as mescaline, peyote, DMT (di-methyl tryptamine), ibogaine, 1 ololiuqui, psilocybin, 2 and LSD-25 (lysergic acid diethylamide_; and stimulants such as the amphetamines and ritalin. 4 Colleagues have reported on the use of the above drugs as well ... [Show full abstract] as others such as meretran, 5 ditran, 6 CO2, and nitrous oxide in various combinations (4). Over the past eight years of research, LSD has been found to be the most effective phar-macological aid in consistently lowering ego defensiveness, enhancing rapportj and making unconscious material available (3). The use of LSD is time-consuming; sessions last from four to eight hours, and sometimes defensive processes inhibit its action for up to two hours, or bring too rapid a decrement to the ongoing experience. In order to answer these difficulties, we fortunately discovered a number of years ago that intramuscular ritalin, given in conjunction with oral LSD, was an excellent way to shorten latency time of LSD action (2). It was further discovered that ritalin (20 to 30 mg. injected intravenously four and five hours after the initial LSD) acted as an agent which shattered ego defenses so that core problems could be constellated and dealt with, and which raised the probability of the occurrence of a mystic experience.