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Bioinformatics for Functional and Structural Genomics at the Protein Design Group CNB-CSIC
Abstract and Figures
The Protein Design Group initiated its activity in 1994 with the incorporation of Alfonso Valencia to the National Centre for Biotechnology CNB-CSIC in Madrid. At that time the orientation of the group was largely a continuation of the work carried out from 1988 to 1994 in the group of Chris Sander at the EMBL in Heidelberg, that, not surprisingly was also called Protein Design Group. Since then the group has adopted new approaches to deal with the avalanche of genomic and structural information, that was just starting in 1994. The application of literature mining to the analysis of expression arrays could be a good example of approaches unpredictable a few years ago. The increasing importance that Bioinformatics have had during the last few years drove us toward the development of professional software closer to the needs of the community, an aspect that was not so clearly perceived when Bioinformatics was still emerging. What remains from the spirit of Chris Sander's group is the interest for the real-world biological problems and the continuous effort for collaborating with molecular and structural biologists. In this article we have summarised our main lines of work in Structural and functional Genomics, describing the concepts behind applications and methods, and pointers to servers where our programs and results are available.
Figures - uploaded by José María Fernández
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