Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis

International Journal of Diabetes in Developing Countries (Impact Factor: 0.37). 04/2007; 27(2). DOI: 10.4103/0973-3930.37036
Source: DOAJ


Ficus bengalensis Linn, commonly known as the banyan tree, belongs to the Moraceae family. Its bark is used for the treatment of diabetes. In the present study, the ethanolic extracts of the different aerial parts of Ficus bengalensis Linn were comparatively evaluated for their blood glucose lowering activity. Histopathology of the treated groups was carried out to evaluate the betacytotropic activity of various parts of Ficus bengalensis. The ethanolic extract of the fruit, at a dosage of 120 mg/kg body weight, was found to exert a more pronounced antidiabetic activity than the ethanolic extract of the root or bark. The experiment also confirmed the antidiabetic activity of the standard drug glibenclamide.

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    • "With this increasing incidences worldwide, DM will likely continue to be a leading cause of morbidity and mortality for the foreseeable future [8] . There has been a very urgent need to discover long term effective treatment for this disease and current interests are being geared towards natural medicines, which account for 80% of the world's primary health care needs according to the WHO [9] . "
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    ABSTRACT: To analyze the cytoprotective and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocos nucifera belonging to the Arecaceae Family. The phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera inflorescence. The free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay models. The phytochemical analyses on inflorescence showed the presence of phenolic compounds, flavonoids, resins and alkaloids. The macronutrient analyses, on the other hand, showed the presence of carbohydrate, proteins and fibers. Administration of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in hyperglycemia. The cytoprotective property of coconut inflorescence was evidenced from the acute toxicological evaluation. The levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control rats. The results obtained from the present study apparently proved the non-toxic nature and the cytoprotective and antihyperglycemic properties of coconut inflorescence.
    Preview · Article · Oct 2013 · Asian Pacific Journal of Tropical Medicine
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    • "The viscous dark brown mass is than dried in air as dried powered extract. (Sgrawat, al. 2007, Edwin E. 2008). The percentage yield of ethanol extracts of stem barks of FB/DL, FB/GJ and FB/UA was found to be 6.6 %, 9.56 % and 7.0 % respectively. "

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    • "Pharmacologically various extracts of Ficus benghalensis has shown analgesic and antiinflammatory (Thakare V N et al., 2010) 7 , anti-arthritic (Bhardwaj L K et al., 2010) 8 antioxidants (Shukla R et al., 2004) 9 , antidiabetic (Sharma S et al., 2007) 10 , immunomodulatory (Gabhe S Y et al., 2006) 11 and antimicrobial (Gayathri M et al., 2009) 12 activity in experimental animals. "
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    ABSTRACT: ABSTRACT The present laboratory study was carried out to investigate the anthelmintic properties of Ficus benghalensis Linn leaves extracts against Indian earthworms Pheretima posthuma. Alcoholic extract and aqueous extract of leaves were used as test solutions. Albendazole was included as standard drug and normal saline as control. Observations were made for the time taken to paralyze and death of the earthworm. Three concentrations 25mg/ml, 50mg/ml, 100mg/ml of each extract and standard drug at the concentration of 25mg/ml were studied. The results of study indicated that Ficus benghalensis Linn leaves extracts exhibited anthelmintic activity significantly in a dose dependent manner when compared with standard group. For the aqueous extract group the time of paralysis and death time was 3.92 minute and 13.72 minute, while alcoholic extract group showed shortest time of paralysis (P) at 2.12 minute and death (D) at 7.34 minute of earthworms at higher concentration 100mg/ml as compared to standard Albendazole (25mg/ml) paralysis 2.36 minute and death at 6.42 minute respectively. Alcoholic extract showed more pronounced effect than aqueous extract. Whereas the control group worms were observed for full day and night and there was no paralysis or death was found during that period. Keywords: Anthelmintic activity, Albendazole, Ficus benghalensis Linn, Pheretima posthuma
    Full-text · Article · Aug 2012 · Asian Journal of Pharmaceutical and Clinical Research
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