Turmeric: Role in hypertrichosis and acne

ArticleinIndian Journal of Dermatology 52(2) · April 2007with 113 Reads

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    Turmeric has been used as a medicine, a condiment, and a dye since at least 600 B.C., while ginger has been used extensively throughout history for its medicinal purposes. The Agronomy and Economy of Turmeric and Ginger brings these two important plants together in one reference book, explaining their history, production techniques, and nutritional and medicinal properties in detail. This book is intuitively organized by plant and use, allowing quick access to information. It puts the uniquely Indian use and history of turmeric and ginger plants into a global context of production and economic aspects. It explores the plants from a botanical perspective, and goes into details of their chemical composition as well. Rounding out the book are chapters on disease and pest control issues. The book is a valuable resource for those involved in the production and marketing of these plants, as well as those looking for more information on the medicinal and nutritional properties of turmeric and ginger. The first book to bring together extensive information about turmeric and ginger Incorporates medicinal, nutritional and agricultural aspects of the two plants Offers a global perspective.
  • Here, we report the fabrication of a curcumin-releasing porous silk fibroin scaffold by simple mixing of fibroin solution (aqueous) with curcumin solution (organic) followed by freeze-thaw of the mixture. The scaffold has a uniform pore distribution with an average pore size of ∼115 μm and a degree of swelling of 2.42% and water uptake capacity of 70.81%. Fibroin showed thermal stability up to ∼280°C, whereas encapsulated curcumin disintegrated at ∼180°C. Fourier transform infrared, powder X-ray diffraction, and nuclear magnetic resonance studies together with UV-visible and fluorescence spectroscopy investigations revealed the solvent (which was used to dissolve curcumin) induced conformational transition of fibroin from silk-I to silk-II that led to the formation of water-stable structure. Fluorescence spectroscopy data also suggested the presence of hydrophobic domains in fibroin and encapsulation of curcumin in such domains through hydrophobic interactions. Release kinetics and mathematical modeling studies indicated a slow and sustained release profile with diffusion as the predominant mode of release. Further, in vitro anticancer, antioxidant, and antimicrobial assays suggested that the biological activity of encapsulated curcumin remains unaltered. The fabrication process is simple, reproducible, and does not require any sophisticated instruments or toxic crosslinking agents. It is anticipated that the curcumin-loaded fibroin scaffold could be used in soft tissue replacements including localized postsurgical chemotherapy against tumors, dressing material for quick healing of wounds and burns, and other related applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
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