The extragalactic dark matter (DM) annihilation signal depends on the product
of the clumping factor, <\delta^2>, and the velocity-weighted annihilation
cross section, \sigma v. This "clumping factor-\sigma v" degeneracy can be
broken by comparing DM annihilation signals from multiple sources. In
particular, one can constrain the minimum DM halo mass, M_min, which depends on
the mass of the DM
... [Show full abstract] particles and the kinetic decoupling temperature, by
comparing observations of individual DM sources to the diffuse DM annihilation
signal. We demonstrate this with careful semi-analytic treatments of the DM
contribution to the diffuse Isotropic Gamma-Ray Background (IGRB), and compare
it with two recent hints of DM from the Galactic Center, namely, ~130 GeV DM
annihilating dominantly in the \chi\chi\ to \gamma\gamma\ channel, and (10-30)
GeV DM annihilating in the \chi\chi\ to b\bar{b} or \chi\chi\ to
\tau^{+}\tau^{-} channels. We show that, even in the most conservative
analysis, the Fermi IGRB measurement already provides interesting sensitivity.
A more detailed analysis of the IGRB, with new Fermi IGRB measurements and
modeling of astrophysical backgrounds, may be able to probe values of M_min up
to 1 M_sun for the 130 GeV candidate and 10^{-6} M_sun for the light DM
candidates. Increasing the substructure content of halos by a reasonable amount
would further improve these constraints.