The Retinotopic Organization of Macaque Occipitotemporal Cortex Anterior to V4 and Caudoventral to the Middle Temporal (MT) Cluster

The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.34). 07/2014; 34(31):10168-10191. DOI: 10.1523/JNEUROSCI.3288-13.2014


The retinotopic organization of macaque occipitotemporal cortex rostral to area V4 and caudorostral to the recently described middle temporal (MT) cluster of the monkey (Kolster et al., 2009) is not well established. The proposed number of areas within this region varies from one to four, underscoring the ambiguity concerning the functional organization in this region of extrastriate cortex. We used phase-encoded retinotopic functional MRI mapping methods to reveal the functional topography of this cortical domain. Polar-angle maps showed one complete hemifield representation bordering area V4 anteriorly, split into dorsal and ventral counterparts corresponding to the lower and upper visual field quadrants, respectively. The location of this hemifield representation corresponds to area V4A. More rostroventrally, we identified three other complete hemifield representations. Two of these correspond to the dorsal and the ventral posterior inferotemporal areas (PITd and PITv, respectively) as identified in the Felleman and Van Essen (1991) scheme. The third representation has been tentatively named dorsal occipitotemporal area (OTd). Areas V4A, PITd, PITv, and OTd share a central visual field representation, similar to the areas constituting the MT cluster. Furthermore, they vary widely in size and represent the complete contralateral visual field. Functionally, these four areas show little motion sensitivity, unlike those of the MT cluster, and two of them, OTd and PITd, displayed pronounced two-dimensional shape sensitivity. In general, these results suggest that retinotopically organized tissue extends farther into rostral occipitotemporal cortex of the monkey than generally assumed.

    • "Previous studies demonstrated that pigeons can be successfully trained to discriminate colors, patterns and forms [33,9,66,48]. The motion stimuli were comparable to stimuli used in previous studies that aimed to elicit activation of motion-sensitive areas in primates [64,102,81,43] and pigeons [65]. The stimuli were composed of white moving dots (luminance = 107.17 "
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    • "It consists of 2 parts, a dorsal lower field representation and a ventral upper-field representation. The horizontal meridian is represented anterior to both ventral and dorsal V4 in the macaque brain (Fize et al., 2003;Janssens et al., 2014;Kolster et al., 2014). In the human brain the strongest evidence of homology comes mainly from the ventral part of human V4, which has been mapped by various studies in a corresponding location and with similar visuotopic organization (Brewer et al., 2005;Van Essen, 2005;Swisher et al., 2007;Kolster et al., 2010). "
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