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Comparing the efficacy of dates and oxytocin in the management of postpartum hemorrhage

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Abstract

Introduction: The aim of study was a comparison between dates and oxytocin in prevention of postpartum haemorrhage. In modern obstetrics, general trend to utilize non-aggressive treatment methods that is quite safe, cheap and few symptoms. Date fruit has Calcium, serotonin, tannin, glucose that they are important for bleeding control. Materials and Methods: This study was performed in Imam Reza and Hazrat Zainab Hospitals, Mashhad University of Medical Science. It was clinical trial that was performed on 62 women delivered in hospital. Immediately after placental delivery, 50 gram oral Deglet Noor dates (group 1) and 10 unit of intramuscular oxytocin (group 2) were given. At the same time a Plastic and a cotton sheet were widen under the patients and a pad was placed on the perineum to absorb blood or fluid. All pads were collected until 3 hour after placental delivery and were weighed every one hour. The difference, before and after weight was calculated.( 100 gram increase in weight was considered to be equivalent to 100 ml blood). Result: Blood loss mean in the end of first hour after delivery were significantly different in dates and oxytocin groups (104 ml vs. 141.6 ml, p=0.043), But in second and third hour were not significant, although the bleeding in dates group was less. In whole three hours after delivery the blood loss mean in dates group was significantly less than oxytocin group (162.5 ml vs. 220.7, p=0.02). Conclusions: Use of oral dates after delivery decreases bleeding more than intramuscular oxytocin and it´s a good alternative in normal delivery. Key Words: postpartum haemorrhage, oxytocin, dates

In the name of God
Department of Internal Medicine
Shiraz E-Medical Journal
Vol. 8, No. 2, April 2007

Comparing the Efficacy of Dates and Oxytocin in the Management of
Postpartum Hemorrhage.
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B<!
+!
 2=5) < (
"   " <  !
  !26(45.
) G! ! #" 
< "  ! ! 
4>>       =7 <
<23485 $ < (
"  <  < 
 <    <
48 +< +" & 
+ +<    :+ :
 235&<  A(
  < ! !  !&
!!   306>    
<!!&+!<
!A!
  "  !& < ! (
& <   ! ! 
!&2@15
!  <
!!!&3>F
8F   +   <  
7>F 205 < < A  
!  !  "
+ & "   
+&  !!  
&  <! + A
 + !  !
 &    ! 
B<!!&  !+(< "
275.#<<!!:"
 A    +  (
3><!!<(
<"!!
!& + +!  20333=5. (
 <  A  (
 < ! ! "
H  &< !<  3>
<  A : !!  !
! < +   "<
!!   + &!
!  "  + 
  285 H  
< " + + (
&  !   (
: "   !! (
 205 9! <!  
!A!<&(
    &" &A 
<  !<  <
<"36    "!
 <!(""&
   B<   
+  "   (
<  $  ! 
$ 9<  "&"  
!!&
 !&   $ 2 
<5&==(=8 $<
    
I +
!& 2375
&   + < 
<!  <  < <
  &!!  +< (
&  !  !  +
:    <   
"  < "
<-
3( . <  ,!< 
 !!    (
!"
! =(. <  < "!<
      < 
65

<  "    ! 
     <!  <<
6( . <  ! < 
"+   !!   
< + & ! !" 
!&!!A&+
<  ! !& 2375.
7()!
"+&<
 +  <  <"
   "  
!&+A(
 +   "!! 
!!&+!

)<+  &(
 !! !  +   +
$ <& !  
  C  8   8=
+!&!
G&4>"."!
 !! 2"< 5 + 3> < (
<<! A 2"< '5  "(
  < "   
("!!&
 (A< ""  ! 
!"     + ."! 
  !" !  ! 
 & +!!
)   <
<+-"+=>(64 
"! 4"!"+
61(7= +: +  !&" < + (
!  ! +" (
+=4>>(7>>>""
    &"  (

 << "  &< (
!& (A  !
!" ! <<  (
 ( A  !" 
 !! !  <  
 "  !& 2( A (
!"!&
<   <  ""   A(
!<   5  < (
"  !"  !
+!! !  < <(
   + ! ! 
+ "< 9& < + !!
63 !   < "<  
<  63 !   +
"<   "    " 
! !  ! !&
4> "  ."!   !! +
"&   < "<  3> <
A    + "< 
   ! & + ! 
< !"  ++""
   <" ! !
 3>> "  3>>> "  
&< <!  < !&
9 "  &+"  
+  !& +  B<!
 3 ! ! '! <  <!
+!<"346>748>3=>
31><!&
      ""
+&+  &
&+  !<" ! (
   !   
&< !& + !!  ) (
&"!
     "
 ! + ! ( 
 + ! <"  ( B<
   + ! +
 <    <<! &
!<"2&335
66


) <!     
  "<  A "< +
  !<" " '$ <
!!<
)!!+"+!
 + "<- "  !&
 <   &! +
&<   !&  <<
 < ! + A(
< A(
&! + " A < 
!&!A+""!
     < "" 
<:" !   !"  <:"
)!3+!!&
<<+"<
"<! <<!&
!&"!"   
&(   "(
  A  <! !(
! !&   + 
+  !"  !&  
A "< 2D>>305 2H"
35
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!!!&+"<
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D"&M>>4"
&"(
"("+"<
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< !&  +"<<(
   "   
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23>7 ! I 3738 ! D>>765  
   <  !& 
!"    " (
2 < D>>18 
< D>6=05  <    
 "< + !+    
<)&"  ! !"
<" 6 <  !&   +
"< + "  2D>>=5
+!+   "<
A"<238=4!I==>@
!5 H" =  6   !"
      < 
!!6<!&
H"=-,!"&"6<
!&+"<
H"6-HB<<<
!"6<!&+
<"<
&
)     "
 !&  + (
  A  < !"
  " A+
H"=  &"   !"  
 <  ! &"  ! !(
"<"6<!&
!+"<
A"<A
    "  !  (
68

 !"  "!!  (
23>3=345
"!<
    $!  2383@5
<(
  9"& 2315
:<  ! 230085   <"
! A  & 
<  !"  !&205
!2300@5<<
A("!
 !"   !215
) <  <<! "(
A   <   
&+ !<" A ! !" 
 0>>> +2335 ) 
<"+<(
&  A !  &"
< " 2) D 835 
 +    & 
& < "  
+ "!  <  &(
" 2 D 835  2 D
085   + &" "(
A245
 &+!<"3@<(
+(
< <  2 D ==5
"  + &" !
! +  + +
&"  ! <
"    ! +
!<&"2D@5
&" 2 D ==45  2 D
=415!&<2
D 315 !<" "!   (
&   < (
" <   !  : 
<!& !
&  < " 245
! < !   
!" !&
<
. <   
<" "   !& 
 !  . "
<<! !" !&
+!!  < < "
2=>5   + ! (
     !"  
&"
 !"      
<<
 <!<  &!   <!
 2=35 )   <
 ! "  + &!&
3F   +"   ."! 
 2== =65 )     (
!!" !" 2=75
"   A"   +
  !  #! 
2=4=85. !"
     (
=>(,!(
  !!   "- (
"! A  !
2=35 "! !   !
   < <! 
!" ! )A <
!! <<!  &! (
 <  < + (
 &!  A (
 A"     " (
  !" ! 2=35 .  
" ! !:  
!<  < + ! (
< +    + &
      "
!" & ! <(
"! N !& !" A(
&" <  +O ! 
: 235,!<! B< (
 <<!  2=3 =75 )
<<!! 4>! < I
69

>>0"I'3>3"I'=
>==")  3>> " 
 2=65
 !< <&&<<(
<  <  (
&<<(
"    "   
<<A
'(#
) < +  : .  
.$!
)
3(I$:<I)"!
<<<"-
+&?H!G$
=>>8P432=5-41(86
=(H,)!G?B<
Q<"-!
!("!,!9A#(
 !P=>>8-662=5-13(7
6()&(
<"+(
!)? !#=>>=P@8-@4(
@8
7(!.&'
<"-,$NH #
&=>>7(=>>8? !#P
=>>8
4($<"&G
$ !:&"(
<"-"""
!HP=>>8-@6285-3>=4(
1>
8(,<"H &?'!!
G!!==+Q:$,
+(!!=>>4
@(?!!9!R9&!<A(
<!!&<
("R)$+$
<&!3007
1((RA
"!-!!!
!R'?# !300@P3>72@5-@13(8
0(:<?. !R!(
!!!!"<
<"R !
3008I!2@45-787S81
3>(&!!G9!<.,!)
<A
""!<&(
&+&!!!'?
 !3011P04-6(38
33(&!!G9!<.+ $)
'!"!-R<R&<R(
!"!R""!(
<'$?3011P=0@-3=04S36>>
3=(9!#'$G!<
!!&(
<"'?# !300@P
3>7-668(0
36(!"??$"!(
"<"-
B<!!?!P
=>>8$1@245-466(7>
37(. "
)=>>3
34($,.!&!!G?9!<.
!&A
"!2,&+5)
,!<6#A-<(
+3001
38('<"!.!H<,<$
$!&<(
"? !#=>>3P@6-3(8
3@(<+)G$:H<::
$!&<A"
!!?<!#T =>>3P
@4-=64(73
31(.!R&<
A!&<
"R'?<!
!"&3008I!23>65-
3>81(@6
30(!)(
=>>3
=>(.!$!
@$< 301@
=3(.&G$$IG
+!!.! '
3007
==( !<,
.!<<!"(
<!<%9%&(
%93000
=6(.U:)%&
3006
70

=7(!!$H$,!
!!<!&"+
V"< <!
?<!3008P37265-8=0(
860
=4(<!.W$U&+(
<"X+Q:':
3008-6@>(@6
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Copyright © 2007 by Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. All rights reserved.
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... Dates are a rich source of micronutrients and macronutrients, and per 100 g of dates, contain 64.2 mg of magnesium, 0.5 mg of zinc, 6.03 mg of iron, 70.7 mg of calcium, 864 mg of potassium, and 10.5 µg of vitamin A. This fruit contains serotonin, and natural antioxidants, such as phenolic acid, flavonoids, and tannin [20,21]. Due to its astringent properties, tannin causes contraction in the muscles of the uterus and myometrium [18,22]. ...
... The amount of hemorrhage in the first hour after delivery was significantly lower in the date group than in the oxytocin group. However, this difference was not statistically significant in the second and third hours after delivery [22]. Mojahed et al. investigated the effect of dates on hemorrhage in the first two hours after delivery. ...
... Still, this difference was not statistically significant in the second and third hours after delivery. The total amount of hemorrhage in three hours was significantly lower in the date group than in the control group [22]. Mojahed et al. assessed the effect of date consumption on postpartum hemorrhage. ...
Article
Full-text available
Background: Postpartum hemorrhage, anemia, and iron deficiency are important health problems. Using safe, cheap, and available methods to reduce the amount of hemorrhage after childbirth can be effective for the mother's health during this period. Therefore, this study was conducted to determine the effect of date fruit consumption on the amount of hemorrhage after natural childbirth. Methods: This randomized clinical trial was conducted on 98 women referred to the maternity ward of Al-Zahra Hospital in Rasht using the available sampling method. The primary outcome was postpartum hemorrhage, measured using the Pictorial Blood Loss Assessment Chart (PBLAC). Two hours after delivery, 100 g of date fruits were given to the intervention group, and the amount of hemorrhage was recorded during the first 24 h. Comparison between the two groups was done with the Mann-Whitney test with the Hodges-Lehmann estimator and corresponding exact conditional nonparametric confidence interval (CI) as effect estimate. A P < 0.05 was considered significant. Results: The median of postpartum hemorrhage after normal delivery in the date and control groups was 35.0 [interquartile range (IQR): 22.0 to 39.8] and 39.0 [IQR: 27.5 to 64.5], respectively. Using the Hodges-Lehmann estimator, on average, the median postpartum hemorrhage in the date group was 9.0 (95% CI: 2.00-18.0) units lower than the control group (P = 0.009). Conclusion: Consumption of dates effectively reduces the amount of hemorrhage after natural childbirth; thus, consuming this fruit during postpartum period is recommended. Also to confirm the findings, it is recommended to conduct similar studies in this field. Trial registration: This trial was registered with the Iranian Registry of Clinical Trials; https://www.irct.ir/trial/59197 (IRCT20210607051505N2) on 31/10/2021.
... Due to its astringent properties, tannin causes contraction in the muscles of the uterus and myometrium. Dates also have a laxative effect, which is a stimulus for uterine contractions (23,27). ...
... Khadem et al. compared the amount of hemorrhage in the rst, second, and third hours after delivery in two groups of data and oxytocin recipients. The amount of hemorrhage in the rst hour after delivery was signi cantly lower in the date group than in the oxytocin group, but in the second and third hour after delivery, this difference was not statistically signi cant (27). Mojahed et al. investigated the effect of dates on hemorrhage in the rst two hours after delivery. ...
... In the rst hour after delivery, the amount of hemorrhage in the date group was signi cantly lower than in the oxytocin group, but in the second and third hours after delivery, this difference was not statistically signi cant. The total amount of hemorrhage in three hours was signi cantly lower in the date group than in the control group (27). Mojahed et al. assessed the effect of date consumption on the postpartum hemorrhage. ...
Preprint
Full-text available
Background Postpartum hemorrhage, anemia and iron deficiency are important health problems. Using safe, cheap, and available methods to reduce the amount of hemorrhage after childbirth can be effective for the mother's health during this period. Therefore, this study was conducted to determine the effect of the date fruit consumption on the amount of hemorrhage after natural childbirth. Methods This was a randomized clinical trial that was conducted on 98 women who were referred to the maternity ward of Al-Zahra Hospital in Rasht using the available sampling method. The data collection tool included a questionnaire on personal characteristics and fertility and the Pictorial Blood loss Assessment Chart (PBLAC). Two hours after delivery, 100-gram of date fruits was given to the intervention group and the amount of hemorrhage was recorded during the first 24 hours. Data analysis was performed using independent t-tests, Chi-square, Fisher, Shapiro-Wilk, Kolmogorov-Smirnov, and Mann-Whitney tests. A P < 0.05 was considered significant. Results The mean hemorrhage rate after normal delivery in the two date and control groups was 33.7 ± 16.7 and 50.9 ± 33.3, respectively. The amount of postpartum hemorrhage in the date group was significantly lower than in the control group (P = 0.009). Conclusion Consumption of dates is effective in reducing the amount of hemorrhage after natural childbirth; thus, it is recommended to consume this fruit during the postpartum period. Also to confirm the findings, it is recommended to conduct similar studies in this field. Trial registration This trial was registered with the Iranian Registry of Clinical Trials; https://www.irct.ir/trial/59197 (IRCT20210607051505N2) on 31/10/2021.
... Furthermore, these fatty acids are claimed to be involved in prostaglandins production pathways. As a result, dates can positively improve the energy levels and the muscles' strength of the uterus (13,20,26). ...
... Therefore, the administration of approved natural products needs to be performed cautiously and the high levels of accuracy should be considered regarding the appropriate timing of prescription and elimination of high-risk patients. (13,20,26), the acquired results were not the same, which can be attributed to different methods adopted in these studies. In the study performed by Mojahed et al., the intervention group received the medication immediately after placental withdrawal, including the infusion of 20 units of oxytocin in 1,000 ccs of saline with 100 g of Phoenix dactylifera with a glass of warm water, while the controls were administrated with the infusion of 20 units of oxytocin in 1,000 ccs of saline. ...
... The bleeding rate was assessed up to 3 h of postpartum . The results showed that the administration of Phoenix dactylifera was a more effective approach toward reducing the postpartum hemorrhage, in comparison with an intramuscular injection of oxytocin (26). In the study of Yadegari et al., the intervention group was prescribed 100 g Phoenix dactylifera within the first two hours of the post-delivery phase. ...
... This plant works by three mechanisms of antiinflammatory and antioxidant effects, hormonal effects, and contraction of the smooth muscles of the uterus in reducing heavy menstrual bleeding or other uterine bleeding. In the study of Khadem et al. both nettle and mefenamic acid were effective in reducing heavy menstrual bleeding [29]. ...
... Examining the results of various studies on the effectiveness of dates on postpartum hemorrhage showed that dates have a positive effect on reducing postpartum hemorrhage. In these trials, the existence of a tannin substance has been pointed out, which due to its astringent property causes contraction in the uterine and myometrid muscles and reduces the amount of bleeding after childbirth [22,25,29]. Dill seed plant has a positive effect on postpartum bleeding [24], the cumin plant reduces postpartum bleeding [30], and the nettle plant and priest's bag were effective on menorrhagia [26,28]. ...
... The components of date fruits have an oxytocin-like effect which reduces the requirement of labour induction and augmentation by prompting uterine myometrial cells, and increasing the sensitivity of the uterus (Al-Kuran et al. 2011;Kordi et al. 2014;Razali et al. 2017). Additionally, consuming date fruits has a beneficial impact on reducing postpartum haemorrhage after delivery and increasing breastfeeding milk production (Khadem et al. 2007). Date fruits are considered an excellent option for breakfast on a daily basis, particularly during Ramadan (Al-Shahib and Marshall 2003). ...
Chapter
It is true that date palm (Phoenix dactylifera L.) holds a significant position in the life of Muslims, especially those of Arab culture, due to its cultural, religious, livelihood, and economic significance. It is an essential part of the diet and culture of Saudi Arabia, where the nutritious date palm fruits are typically eaten at the Rutab and Tamer stages. These fruits have been a staple food for Arabs since ancient times and have played a crucial role in improving food and nutritional security and economic circumstances. The functional characteristics and nutritional content of date palm fruits contribute significantly to improving general human health. Consuming an average of seven date fruits by adults can provide approximately 13%, 20%, and 25% of the recommended dietary allowance for energy, dietary fiber, and potassium, respectively. In addition to its nutrient-rich fruits, the date palm is also considered a significant natural renewable resource for many by-products, handicrafts, and architecture. The date palm contributes substantially to the socioeconomic development of nations, particularly Saudi Arabia. Ensuring food security has become a challenge that countries and organizations must address with possible solutions through increasing the cultivation of crops that are rich in nutrients and hold significant commercial values. The high-nutrient fruits of the date palm are a valuable contribution to achieving food and nutritional security at both local and global levels. The primary goal of this chapter is to highlight the research that has been conducted on date palm and its fruits in terms of their roles in food and nutritional security in Saudi Arabia’s diet, culture, life, economy, and society.
... Post-delivery trials indicated the beneficial effect of 50 g fruit intake daily by 31 women in the experimental group compared to the group taking oxytocin by assessing blood loss 3 h after delivering their babies (162.5 ml v/s 220.7 ml) (Khadem et al. 2007). The use of this valuable plant was evaluated by Sadeghi et al. (2018) in the postmenopausal period in the form of a date pollen capsule to assess the extent of vaginal lubrification and dyspareunia compared to a control group that received a simple capsule (Sadeghi Goghari et al. 2018). ...
Article
Appraised for being one of the oldest staple nutritive foods mainly in the Arabian Peninsula, the date palm tree (Phoenix dactylifera L.), is a crop native to the subtropical and tropical regions of Southern Asia and Africa. Different parts of the date tree have been extensively studied for their nutritional and therapeutic properties. Despite an array of publications on the date tree, there has been no attempt to compile in a single study the traditional uses, nutritive value, phytochemical profile, the medicinal properties as well as the potential of the different plant parts as a functional food. Therefore, this review endeavors to systematically review the scientific literature to highlight the traditional uses of date fruit and parts around the world, the nutritional profile of several parts and the medicinal properties. A total of 215 studies was retrieved (traditional uses (n = 26), nutritional (n = 52), and medicinal (n = 84)). Scientific articles were further categorized as in vitro (n = 33), in vivo (n = 35), and clinical (n = 16) evidences. Date seeds were found to be effective against E. coli and Staphylococcus aureus. Aqueous date pollen was used to manage hormonal problems and boost fertility. Palm leaves showed anti-hyperglycemic effects via inhibition of α-amylase and α-glucosidase. Unlike previous studies, this study highlighted the functional roles of all the plant parts of the palm tree and provided insights into the various mechanism of action of their bioactive compounds. Although scientific shreds of evidence have been growing over the years, there is still a dearth of studies concerning the clinical validation of the date fruit and other plant parts to provide strong evidence on their medicinal uses. In conclusion, P. dactylifera can be regarded as a potent medicinal plant with prophylactic potential and should be further explored to alleviate the burden of both communicable and non-communicable diseases.
... In my study the postpartum hemorrhage was not studied but many studied showed favorable results as compared to oxytocin in terms of bleeding after delivery 8 . ...
Article
Background: Effect of dates on pregnancy outcomes is in debate among researchers for optimum results. Aim: To compare the fetomaternal outcome with and without use of dates in primigravidae presenting at 37-38 weeks Main outcome: The outcome was measured as fetal (Apgar score at 5 min) and maternal (onset and induction of labor) parameters. Study design: Randomized controlled trial Setting: Department of Obstetrics and Gynaecology, District Headquarter Hospital, Gujranwala Duration of study: 6 months 1st January 2020 to 30th June 2020 Methods: A total of 110 patients reporting to OPD in their first pregnancy between 18 to 35 years of age at 37 to 38 weeks were included whereas multigravidae and those with previous miscarriage were excluded. Consecutive Non Purposive Sampling technique was used and patients were randomly divided in two groups of 55 each. Group A consumed dates in late pregnancy while Group B was asked not to. Duration of first and second stage of labour and Apgar score at 5 minutes were recorded. SPSS version 21 was used to enter and analyze the data. Quantitative variables Apgar score were presented in the form of mean ± SD. Qualitative variables like spontaneous labour, need for induction and good Apgar score were presented in the form of frequency and percentage. Chi-square test was applied to compare spontaneous labour, need for induction, and good Apgar score in both groups. P-value ≤0.05 was taken as significant. Results: The mean apgar score at five minutes was 8.76±1.157. The analysis of qualitative variables showed that spontaneous labor was started in 75(68.2%) of patients and induction was required in 35 (31.8%) patients. There was successful induction in 1 (9.1%) of patients. At five minutes 101(91.8%) of neonates showed good apgar i.e. >7. Both groups were compared among each other in terms of both quantitative and qualitative variables. The onset of spontaneous labor, success of IOL and good apgar score at 5 minutes were compared among groups. The was significant difference among groups A and B in terms of these parameters except good apgar score i.e. p values of 0.008, 0.021 and 0.297 for spontaneous labor, IOL and good apgar scores Good apgar score at 5 min was not statistically significant among any stratification group. Conclusion: The consumption of dates significantly improves the fetomaternal outcomes in primigravida term pregnancies. The results should be validated in large randomized controlled trials. Keywords: Date fruit, Labour outcomes, Labour progression.
Conference Paper
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article is distributed under a Creative CommonsAttribution (CC-BY) 4.0 license. Abstract: Infertility and cancer are a major public health challenge globally. Date palm pollen (DPP), the male reproductive cells of the palm tree's flowers, has a long-standing use as a nutritional supplement, especially as an aphrodisiac and fertility ameliorative. Recently, some studies have looked into its effect against some types of cancer. This study sought to assay the impact of DPP extract (DPPE) supplementation on the fertility of adult healthy male Swiss albino mice in vivo and to evaluate its cytotoxic effect against human rhabdomyosarcoma (RD) cancer cell line in vitro. Forty male mice were randomly divided into two groups (n=20) including control and the treatment group. DPPE was dissolved in distilled water and orally given to the treatment group at a dose of 250 mg/kg once daily for 35 days while the control group received distilled water. At the end of the administration, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, estradiol, final body and male reproductive organs weights, and sperm parameters were evaluated. In addition, the percentage of cancer cell growth inhibition (GI) of eight concentrations in μg/ml (0.19, 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25) were assessed in vitro using RD cell line. DPPE dose significantly increased the weight of reproductive organs (prostate gland, seminal vesicle, and epididymis), sperm indices (concentration, motility, morphology), estradiol levels (P < 0.001), LH (P < 0.01), and testosterone (P<0.001) compared to the control group. Concerning the anti-tumor properties of the extract, the results showed that they were a concentration-independent effect. DPPE recorded the best GI values on the RD cell line in the 0.19 and 1.56 μg/ml range. This study concluded that DPP has a clear effect on improving the male fertility profile and development of the male reproductive system in adult male Swiss albino mice, in addition to its concentration-independent anti-cancer effect.
Article
Full-text available
Introduction: Preparation of the cervix and induction of labor is necessary before the onset of labor. In traditional medicine, rose has been used as an effective factor in the onset of labor contractions. However, clinical studies on its efficacy are very rare. This study was done to determine the effect of oral rose-water on cervical ripening in primiparous women. Methods: This study was a randomized clinical trial on 60 primiparous women with 40 weeks of gestation who were assigned to two groups of 30 people of intervention and control using method of intervention blocks. Intervention group consumed five ml of Rose water daily orally since 40 week of gestation for one week and the control group, was received routine care. One, three and seven days after beginning of the intervention and entering the labour, Bishop's score was measured. Data were gathered by a questionnaire form, physical examination, observing and counting fetal movement and check list of rose-water consumption. Data were analyzed using T-tests, analysis of variance and repeated values. Results: The mean age of patients in the intervention and control group was 26.53± 5.16, 26.53± 5.28 respectively. The onset of labor did not show a significant difference in two groups(p=0.303). Analysis of variance in duplicate measurements showed that the mean of Bishop's grade point average on the third and seventh days after beginning of intervention in the two groups did not differ significantly from each other (p =0/160). Also, the results of this test showed that the trend of bishop score changes in both groups was incremental. Conclusion: Consumption of 5 ml of rose-water daily, no significant effect on preparing cervix and was safe. It is recommended for future research to assess the effect of higher dose of rose-water on preparing cervix. and induce labor, compare it with the control group, for future research. Keywords: Delivery, Cervical ripening, Rosewater, Term pregnancy
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