5-Amino-4-(4-di­methyl­amino­phenyl)-2-(4-methoxy­phenyl)-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbo­nitrile

ArticleinActa Crystallographica Section E Structure Reports Online 59(2) · February 2003with7 Reads
DOI: 10.1107/S1600536803001235
Abstract
In the title compound, C28H28N6O, the naphthyridine moiety is planar and the pyrrolidine ring adopts a half-chair conformation. The di­methyl­amino­phenyl substituent is nearly orthogonal to the naphthyridine moiety, while the methoxy­phenyl ring is twisted from it by 11.3 (2)°. The molecular structure is stabilized by an N—H⋯π interaction. In the solid state, the inversion-related mol­ecules are linked to form N—H⋯N hydrogen-bonded dimers. The molecular packing is stabilized by weak C—H⋯π and π–π interactions.
  • [Show abstract] [Hide abstract] ABSTRACT: This chapter reviews the analysis made of the synthesis and properties of six isomeric heterocyclic systems containing two fused pyridine rings with different mutual arrangements of nitrogen atoms; naphthyridines. The interest in naphthyridine derivatives is due to its practical importance. They have an exceptionally broad spectrum of biological activities, and are used for the diagnosis and treatment of different human diseases; agriculture, animal husbandry for external- and internal-parasite control, in industry as preservatives and components of lubricating coolants for metal processing, and in analytical chemistry as ligands. The analysis of the data on the synthesis, chemical properties, and biological activities of the six isomeric pyridopyridines published over the last 20 years is indicative of a lively interest in different aspects of their chemistry. This interest is generally associated with the practical utility of their derivatives possessing a very broad spectrum of the biological activities.
    Article · Oct 2006