Granulomatosis with polyangiitis presenting with pachymeningitis

Journal of the Neurological Sciences (Impact Factor: 2.47). 06/2014; 344(1-2). DOI: 10.1016/j.jns.2014.06.052
Source: PubMed


This case report describes a 75 year-old Caucasian male who initially presented with persistent daily headaches. Physical exam elicited multiple cranial nerve palsies. Gadolinium-enhanced brain MRI demonstrated pachymeningitis. Labs revealed elevated proteinase-3 antineutrophil cytoplasmic antibodies (PR3-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA), confirming a diagnosis of GPA.

GPA should be considered in older patients presenting with persistent daily headaches and pachymeningitis. Contrast-enhanced brain MRI is an important diagnostic tool.

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