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The Effects of Inositol Extracted from Rice on the Skin
Abstract
Inositol, is a water-soluble crystalline compound. It helps with people’s metabolism and decreases cholesterol levels. It is also known to have anti-cancer results. In order to find out the affects of Inositol on the skin, Inositol skin lotion was produced with each amount of Inisitol: 0, 0.5, 1.0, 2.0, 3.0 wt% and tested on the faces and the arm areas of women in all ages for 7 weeks. The moisture, sebum, change in elasticity, and improvement of wrinkles were measured. Corneometer, Sebumeter, Cutometer, and an image analyzer were used as measuring equipments. There are subtle differences in the subjects when 1-2% of Inositol is used the moisture of the skin improved 19%, elasticity by 17%, and the amount of sebum for dry and oily skin types adjusted to the amount of sebum of the neutral skin types. This influenced the length, width, the number of peak, and the height of the wrinkles to improve 12.4%. It is thought that Inositol would be an effective new raw material in cosmetics.
Background:
Xerosis is an extremely common condition, especially in the elderly population. It is the most common cause of pruritus in the older adult. Since xerosis is generally caused by a lack of epidermal lipids, the use of leave-on skin care products is the mainstay treatment. The aim of this open prospective analytical observational study was to investigate the clinical and self-reported hydrating efficacy of a moisturizer formulation containing a synergy between amino-inositol and urea (INOSIT-U 20) in patients with psoriasis and xerosis.
Methods:
Twenty-two patients with psoriasis successfully treated with biologic therapy, and who presented xerosis, were recruited. Each patient was instructed to apply the topical with a frequency of two applications per die on the identified skin area. Corneometry values and a VAS itch questionnaire were measured at baseline (T0) and after 28 days (T4). To evaluate the cosmetic efficacy, the volunteers also completed a self-assessment questionnaire.
Results:
Comparing Corneometry values at T0 and T4, a statistically significant increase value was observed in the area subjected to topical treatment (P<0.0001). A significant decrease in itch (P=0.001) was also observed. Moreover, the patients' ratings of the cosmetic properties of the moisturizer showed significant confirmation rates.
Conclusions:
This study provides preliminary evidence that INOSIT-U20 provides a good hydrating effect on xerosis, further reducing self-reported itch.
Inositol and phytic acid extracted from rice bran were investigated for applying cosmetics. Skin lotions containing inositol and phytic acid were applied respectively, to the arm skins of 45 Asian women 20'~40's for 7 weeks. Improvement on moisture was evaluated. In addition, improvements on sebum, elasticity, and wrinkle were examined after applying placebo, inositol and phytic acid-containing skin lotions tot face, respectively. For inositol, it resulted in increase of moisture. The wrinkle reduction and elasticity improved on average, respec-tively. Applying phytic acid resulted in increase the moisture. Improvements on wrinkle and elasticity were respectivelv. hpplving inositol or phytic acid regardless of dry or oily skin, resulted in sebum value recovery to that of the normal skin after 2~4 weeks. Although inositol is inferior to phytic acid in improvements of the skin, phytic acid is not suitable to sensitive skin. So, of phytic acid were added to inositol and similar experiments were carried out. In case of added phytic acid, moisture increased approximately. Improvements on elasticity and reduction on wrinkle were respectively. Both skin types were turned to normal skin type after 2 weeks. It could improve the skin condition when used inositol added phytic acid. The optimized concentration of phytic acid was of inositol without side effect.
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