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Awareness and timing of pelvic floor muscle contraction, pelvic exercises and rehabilitation of pelvic floor in lifelong premature ejaculation: 5 years experience

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Abstract

Objectives: To assess the cure rate of patients with premature ejaculation who underwent a treatment involving: 1) awareness of the pelvic floor muscles 2) learning the timing of execution and maintenance of contraction of the pelvic floor muscles during the sensation of the pre-orgasmic phase 3) pelvic floor rehabilitation (bio feed back, pelvic exercises and electrostimulation). Materials and methods: We recruited 78 patients with lifelong premature ejaculation who completed the training. The patients were informed of the role of the pelvic floor. They were taught to carry out the execution and maintenance of contraction of the pelvic floor muscles during the sensation of the pre-orgasmic phase to control the ejaculatory reflex. In order to improve the awareness, the tone and the endurance of the pelvic floor muscles, patients were treated with the rehabilitation of pelvic floor (RPF) consisting mainly in biofeedback, pelvic exercises and in some cases also in electro-stimulation (ES). The training was carried out for a period of about 2-6 months with an average of 2-5 visits per cycle. Results: 54% of patients who completed the training were cured of premature ejaculation and learned over time to be able to postpone the ejaculation reflex. In a subgroup of 26 patients was also measured the IELT which on the average increased from < 2 minutes to >10 minutes. The best results occurred mainly in patients aged less than 35 where the cure rate was 65%. There were no side effects. Conclusions: In this study, approximately half of patients with premature ejaculation were cured after applying the above treatment.This therapy, necessitates a fairly long period of time (2-6 months) and a great commitment on the part of the patient, nevertheless it can be a valid and effective treatment for patients with premature ejaculation. This treatment makes the patient independent in that he is not bound to specific times for taking medication. Furthermore there are no side effects and this therapy is particularly effective in young males.
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Archivio Italiano di Urologia e Andrologia 2014; 86, 2
ORIGINAL PAPER
Awareness and timing of pelvicoor muscle contraction,
pelvic exercises and rehabilitation of pelvic oor
in lifelong premature ejaculation: 5 years experience
Giuseppe La Pera
Department of Urology, San Camillo Forlanini Hospital, Rome, Italy.
Objectives: To assess the cure rate of
patients with premature ejaculation who
underwent a treatment involving: 1) awareness of the pelvic
floor muscles 2) learning the timing of execution and main-
tenance of contraction of the pelvic floor muscles during
the sensation of the pre-orgasmic phase 3) pelvic floor
rehabilitation (bio feed back, pelvic exercises and electro-
stimulation).
Materials and methods: We recruited 78 patients with life-
long premature ejaculation who completed the training.
The patients were informed of the role of the pelvic floor.
They were taught to carry out the execution and mainte-
nance of contraction of the pelvic floor muscles during the
sensation of the pre-orgasmic phase to control the ejacula-
tory reflex. In order to improve the awareness, the tone and
the endurance of the pelvic floor muscles, patients were
treated with the rehabilitation of pelvic floor (RPF) consist-
ing mainly in biofeedback, pelvic exercises and in some
cases also in electro-stimulation (ES). The training was car-
ried out for a period of about 2-6 months with an average
of 2-5 visits per cycle.
Results: 54% of patients who completed the training were
cured of premature ejaculation and learned over time to be
able to postpone the ejaculation reflex. In a subgroup of 26
patients was also measured the IELT which on the average
increased from < 2 minutes to >10 minutes. The best results
occurred mainly in patients aged less than 35 where the
cure rate was 65%. There were no side effects.
Conclusions: In this study, approximately half of patients
with premature ejaculation were cured after applying the
above treatment.This therapy, necessitates a fairly long
period of time (2-6 months) and a great commitment on the
part of the patient, nevertheless it can be a valid and effec-
tive treatment for patients with premature ejaculation. This
treatment makes the patient independent in that he is not
bound to specific times for taking medication. Furthermore
there are no side effects and this therapy is particularly
effective in young males.
KEY WORDS: Premature ejaculation; Awareness; Timing;
Pelvic floor muscles; Pre-orgasmic sensation.
Submitted 26 May 2014; Accepted 16 June 2014
Summary
No conflict of interest declared.
DOI: 10.4081/aiua.2014.2.123
INTRODUCTION
The pelvic floor rehabilitation (PFR) consisting in biofeed-
back, pelvic exercises (kinesis-therapy) and pelvic floor
electrical stimulation in the treatment of lifelong prema-
ture ejaculation has been introduced since 1996 (1) and
was later confirmed by other authors (2).
Since then, from 2008, compared to the previously
described technique, I introduced some changes in the
therapeutic protocol:
1. adopting the new definition of premature ejaculation
(PE) of the ESSM (3);
2. introducing into the protocol the awareness of the
pelvic floor muscles (4);
3. teaching patients when to execute and maintain the
contraction of the pelvic floor muscles. In order to
inhibit the ejaculatory reflex this contraction must
occur during the sensation of the pre-orgasmic phase.
As regards the changes to the protocol of training, these
are based on the observation that patients with prema-
ture ejaculation very often are not aware of the role of the
pelvic floor muscles (4). Therefore some patients may
suffer premature ejaculation simply because they do not
know what to do or are not able to make a selective effec-
tive contraction of the pelvic floor and not because of an
early arrival of the stimulus. The purpose of this study
was to evaluate the cure rates in an unselected popula-
tion of patients with lifelong premature ejaculation
undergoing rehabilitation treatment of the pelvic floor
who have been taught the role of the pelvic floor and the
timing of contraction of these muscles.
MATERIALS AND METHODS
Recruitment of patients
We retrospectively reviewed the charts of 108 patients with
lifelong premature ejaculation. Out of them 78 patients
(72%) completed the protocol training. Patients with erec-
tile dysfunction and patients with signs of prostatitis were
excluded. The majority of patients excluded from treat-
ment or who did not complete the protocol preferred an
immediate drug treatment instead of a treatment that
Archivio Italiano di Urologia e Andrologia 2014; 86, 2
G. La Pera
124
required numerous sessions spread over a period of sever-
al months. The average age was 41 +/- 8 and a median age
of 40 (range 18 to 64).
Definition of a patient with premature ejaculation
The definition of a patient with premature ejaculation
refers to the definition adopted by the ESSM 2008 (3); all
patients had the IELT (5) in less than one minute and a
PEDT (6) test > 11. In the hormone screening was found
only one patient with hyperthyroidism; in all the other
patients, the hormonal values of the thyroid function
were always found normal. Eight patients had a signifi-
cantly low testosterone. In all these cases of hormonal
alteration, the hormonal treatment implemented to cor-
rect hypogonadism or hyperthyroidism did not change
the symptoms of premature ejaculation.
Description of the technique
The technique to inhibit the ejaculatory reflex and to
teach the patient how to take greater control consists of
four steps. The 4 steps are:
1) Have the patient become aware of the existence of the
pelvic floor muscles;
2) Teach the patient the selective contraction of the mus-
cles of the pelvic floor;
3) Teach the patient and have him try out the timing of
the execution and maintenance of contraction of the
muscles of the pelvic floor during the sensation of the
pre-orgasmic phase;
4) Reinforcement of the pelvic floor muscles.
Awareness of the role of pelvic floor muscles
At the beginning of treatment, all patients were made
aware of the role of the pelvic floor through a test
described in 2012 (4). In practice, the patient lying
down is asked to contract his pelvic floor muscles while
performing a digital rectal examination. At the end of
this procedure the patient is asked whether he is aware
that the contraction of the muscles of the pelvic floor is
able to inhibit the ejaculatory reflex. A more accurate
description of this technique and the demonstration of
its validation was previously published (4)
Pelvic floor rehabilitation (PFR)
To learn how to selectively use the muscles of the pelvic
floor, i.e. without activating antagonist muscles such as
the abdominal muscles, we used the technique of PFR
that involves biofeedback, pelvic exercises and in some
cases electro-stimulation. This technique has already
been described for fecal and urinary incontinence and in
the treatment of premature ejaculation (1). The PFR not
only reinforces the tone and strength of contraction of
the pelvic floor muscles but at the same time allows the
patient to better understand the role of these muscles
and acquire the capacity to perform the contraction
selectively. A more detailed description of the technique
was previously published in 1996 (1).
Nearing the orgasmic phase and timing
of the contraction of the pelvic floor muscles
One of the techniques used up to now for the treatment
of premature ejaculation has historically been that of
stop and startproposed by Masters and Johnson since
the 1960’s (7). Basically it consists in stopping the stim-
ulation when the excitation reaches the pre-orgasmic
p
hase and and when the ejaculation is about to arrive.
The innovation we have brought to our technique is that
of adding, during the sensation of the pre-orgasmic
phase, the execution and maintenance of contraction of
the muscles of the pelvic floor until the sensation of
upcoming orgasm has passed.
To obtain this result obviously the first step is to be
informed of the existence and the role of the pelvic floor
muscles. The second moment is to be able to carry out the
contraction of the muscles of the pelvic floor in a selective
manner and this can be obtained through biofeedback.
The third element consists of the selective and coordinat-
ed contraction of the pelvic floor muscles to be carried
out at the very pre-orgasmic moment before ejaculation
becomes irreversible. This technique starts from the
assumption that the contraction, performed in a coordi-
nated and timely way, would be able to inhibit the ejacu-
latory reflex similarly to what happens in the bladder
where the contraction of the pelvic floor muscles if done
at a certain moment is capable of delaying the urge of uri-
nation through inhibition of detrusor contraction (8).
In order to teach the patient the timingof the contrac-
tion and have him figure out at what moment of pre-
orgasmic sensation it is still possible to inhibit the ejacu-
latory reflex, exercises of masturbation are assigned to do
at home. In these focusing exercises the patient begins to
masturbate and gets to a stage of pre-orgasmic excite-
ment; through trial and errorhe must learn to be able
to recognize in what moment during the sensation of
pre-orgasmic excitement it is still possible to inhibit the
ejaculatory reflex in stopping masturbation, contracting
the muscles of the pelvic floor and maintaining the con-
traction until the sensation of imminent orgasm ceases.
Once the patient has achieved inhibition of the ejaculato-
ry reflex and the sensation of imminent orgasm ceases the
patient resumes masturbation and in the same session
repeats this cycle 3 or 4 times. After 4 or 5 cycles the
patient can let himself reach ejaculation. The results of this
training and in particular the way the contraction is per-
formed and its effectiveness in postponing the ejaculatory
reflex are discussed with the patient once a month; any
doubts are cleared up and further improvements made.
Measurement of results and definition of healing
Patients were considered cured if able to control their
ejaculatory reflex and when they pass from a PDET score
above 10 to one equal or less than 8. Furthermore in one
group of patients was evaluated the IELT (5) both before
and at the end the training.
RESULTS
All patients at the end of the training due to awareness
tests (4) have become conscious of the role of the pelvic
floor in the control of ejaculation; 43 patients or 55% of
all those who completed the training were cured of pre-
mature ejaculation and learned to be able to postpone
the moment of ejaculation. In a subgroup of 26 patients
was also measured the IELT which on the average went
from < 2 minutes to > 10 minutes. The best results
occurred mainly in patients aged less than 35 where the
cure rate was 65%. In the course of more than five years,
t
here were no side effects in the whole sample involved.
Thirty-five patients (45%) after a minimum period of
three months did not demonstrate any benefit from the
technique proposed here and drug therapy was begun
with them. The non-response to treatment was mainly
due to the fact that the patient was not able to selective-
ly contract the pelvic floor muscles or could not recog-
nize the moment to make the contraction. Among these
35 patients, however, there were 12 in which the patient,
even though making a regular and effective contraction
of the muscles of the pelvic floor and even recognizing
the moment when it was necessary to perform the con-
traction, had no beneficial effect on the length of ejacu-
latory latency. Probably this subset of patients is that in
which premature ejaculation is the consequence of the
early arrival of the ejaculatory stimulus.
DISCUSSION
Awareness of the role of the pelvic floor muscles, the PFR
and learning to recognize the timing of the execution and
maintenance of contraction of the pelvic floor muscles
are the crucial elements of this technique in order to
inhibit and improve control over the ejaculatory reflex.
The limit of this method is that it takes a few months for
the patient to understand the dynamics of the sequence
of events, learn control over the ejaculatory reflex and
naturally carry it during sexual intercourse. In many
family and clinical situations there is not always a long
time available and thus the patient may request some-
thing faster such as drug therapy available today.
Another limitation of this technique is that not all
patients are able to perform a selective contraction of the
pelvic floor muscles without activating other antagonist
muscles or are not able to recognize the sensation that
precedes the inevitability of ejaculatory reflex in order to
perform the contraction of the muscles of the pelvic floor
to block and inhibit ejaculation.
In the course of this experience, we observed that
although some patients were able to correctly perform the
contraction of the muscles of the pelvic floor this tech-
nique did not prove effective. This percentage of patients
is typically around 15%. These limits are, however, large-
ly offset by the fact that recovery from premature ejacula-
tion with this technique brings the patient around to be
independent”, not influencing his sexual activity by taking
a drug and not exposing him to potential side effects or
drug interactions. These results confirm moreover the fact
that the population of patients with premature ejaculation
is a heterogeneous population with different etiological
factors. There are not only patients in whom there is an
early arrival of the ejaculatory reflex.
The positive results of this technique, which does not act
on the arrival of the ejaculatory reflex but only on the con-
trol, suggest the hypothesis that premature ejaculation, in
some cases, may be due to another four causes:
lack of knowledge of the fact that is necessary to con-
tract the pelvic floor muscles;
inability to contract these muscles;
inability to know how to recognize at what moment
during the sensation of the pre-orgasmic phase it is
still possible to block the ejaculatory reflex;
result of a disease of the muscles of the pelvic floor.
These data raise therefore the urgent need not only to
reassess the definition of premature ejaculation or at least
redefine the concepts that define it but to re-evaluate the
criteria for inclusion or exclusion in therapeutic trials on
premature ejaculation taking into consideration the vari-
ables of awareness and neuromuscular coordination of
the pelvic floor, the perception of the arrival of the ejac-
ulatory reflex and diseases of the pelvic floor muscles.
CONCLUSIONS
In this study, approximately half of the patients with pre-
mature ejaculation were cured after they learned role and
use of the muscles of the pelvic floor, having learned the
timing of execution and maintenance of contraction of the
pelvic floor muscles during the sensation of the pre-orgas-
mic phase and having undergone PFR. Despite the fact that
this therapy in order to achieve positive results requires a
fairly long period of time (2-6 months) and a greater com-
mitment on the patient’s part, it can be a valid and effective
treatment to offer a patient with premature ejaculation.
This treatment makes the patient independent in that he is
not bound to specific times for taking medication.
Furthermore there are no side effects and this therapy is
particularly effective in young males.
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Archivio Italiano di Urologia e Andrologia 2014; 86, 2
Awareness and timing of pelvic floor muscle contraction, pelvic exercises and rehabilitation of pelvic floor in lifelong premature ejaculation
Correspondence
Giuseppe La Pera, MD (Corresponding Author)
lapera@libero.it
Dept of Urology, San Camillo Forlanini Hospital, Rome, Italy
... Repeated sessions of behavioral therapy are also used to prove additional pelvic floor rehabilitation. 5,6 One previous study revealed that mean intravaginal ejaculation latency time (IELT) increased from 39.8 to 146.2 seconds after 12-week behavioral therapy. . Level 1 is the softest type with mild tightness, and level 5 is the hardest type with the strongest tightness. ...
... 5 Another study revealed that among patients completing behavioral therapy, 54% were cured of PE, and over time they learned how to postpone their ejaculation reflex. 6 The main barriers to sexual and behavioral therapy for PE are accessibility, counseling fees, and weak evidence of the benefits of therapy. 3 Ideal therapy for PE would include curability, accessibility, few side effects, low cost, and the ability for patients with PE to train themselves. ...
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... PFM training including exercises that improve PFM control can increase intravaginal ejaculation latency time in men with PE [8]. Stronger superficial PFM may enhance orgasmic satisfaction during ejaculation [9]. A systematic review by Gbiri et al. highlighted the positive impact of PFM training on sexual function, concluding that PPT can be considered a valuable non-pharmacological intervention [7]. ...
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... [4] The importance of PFM awareness in the management of pelvic floor dysfunctions other than incontinence has been demonstrated in previous studies. [27,28] Raising awareness and increasing the level of knowledge is essential for pelvic floor rehabilitation and maintaining adequate muscle contraction. This study has some limitations. ...
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Diagnosis of premature ejaculation (PE) for clinical trial purposes has typically relied on intravaginal ejaculation latency time (IELT) for entry, but this parameter does not capture the multidimensional nature of PE. Therefore, the aim was to develop a brief, multidimensional, psychometrically validated instrument for diagnosing PE status. The questionnaire development involved three stages: (1) Five focus groups and six individual interviews were conducted to develop the content; (2) psychometric validation using three different groups of men; and (3) generation of a scoring system. For psychometric validation/scoring system development, data was collected from (1) men with PE based on clinician diagnosis, using DSM-IV-TR, who also had IELTs < or =2 min (n=292); (2) men self-reporting PE (n=309); and (3) men self-reporting no-PE (n=701). Standard psychometric analyses were conducted to produce the final questionnaire. Sensitivity/specificity analysis was used to determine an appropriate scoring system. The qualitative research identified 9 items to capture the essence of DSM-IV-TR PE classification. The psychometric validation resulted in a 5-item, unidimensional, measure, which captures the essence of DSM-IV-TR: control, frequency, minimal stimulation, distress, and interpersonal difficulty. Sensitivity/specificity analyses suggested a score of < or =8 indicated no-PE, 9 and 10 probable PE, and > or =11 PE. The development and validation of this new PE diagnostic tool has resulted in a new, user-friendly, and brief self-report questionnaire for use in clinical trials to diagnose PE.
Article
The DSM-IV diagnostic criteria for premature ejaculation remain to be investigated by a clinical study. A prospective study was therefore conducted to investigate the DSM-IV definition and to provide an empirical operationalization of premature ejaculation. In this study 140 men suffering from lifelong premature ejaculation were interviewed separately from their partners. Various means of assessing the intravaginal ejaculation latency time (IELT) were compared: assessment by spontaneous answer, by questionnaire, by imagining foreplay and intercourse and estimating the ejaculation time without a clock or with a clock, and by stop-watch measurement at home over a one-month period. The number of thrusts and feelings of control during foreplay and intercourse were also assessed. A total of 110 men used the stop-watch method. Ninety percent of all the subjects ejaculated within one minute of intromission, with 80% actually ejaculating within 30 seconds. The age of the men and duration of their relationship were not correlated with IELT; however, the IELT tended to be longer for couples who had a higher frequency of intercourse. There was only a moderate correlation between the various methods of assessing IELT. The results suggest that premature ejaculation could be operationally defined as an IELT < 1 min in more than 90% of episodes of sexual intercourse, independent of age and duration of relationship.
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The difficulty in correctly identifying the etiologic factors of premature ejaculation (PE) could be due to the fact that the role of the pelvic floor muscles (PFMs) in the voluntary control of ejaculatory reflex has not been elucidated. The aim of the present investigation was to measure the prevalence of awareness of the role and use of PFM contraction in controlling the ejaculatory reflex among PE and non-PE participants. A total of 44 men with PE and 73 men without PE were recruited. In the first part of the study, we validated a test that rendered the participants aware of the PFMs through digital rectal examination and the PFM contraction. In the second part, we posed this multiple-choice question: "Which muscles do you use to delay ejaculation?". Men not answering correctly were considered not to be using the PFMs and also to be unaware that it is necessary to contract the PFMs to control the ejaculatory reflex. Only 3 of 44 subjects (6.8%) with PE and 60 of 73 subjects (82%) without PE answered correctly and used PFMs to control the ejaculatory reflex (Fisher test p < 0.0001). This test has a sensibility of 93%, a specificity of 82%, and an accuracy of 86%. The vast majority of PE subjects were unaware that to inhibit or delay ejaculation it is necessary to contract the PFMs. This association also raises the question whether the difficulties in defining PE and finding effective PE therapies could be due to a nonhomogeneous population of PE patients with different etiopathogenetic factors. More studies are required to confirm these data and to answer this question.
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Premature ejaculation (PE) is the most common male sexual disorder. We compared pelvic floor muscle rehabilitation to on-demand treatment with the selective serotonin reuptake inhibitor dapoxetine in 40 men with lifelong PE (baseline intra-vaginal ejaculatory latency time (IELT) ≤1 min). Subjects were randomized into the following two treatment groups: (1) PFM rehabilitation or (2) 30 or 60 mg of on-demand dapoxetine. Total treatment time for both groups was 12 weeks, at the end of which, IELT mean values were calculated to compare the effectiveness of the two different therapeutic approaches. At the end of treatment, 11 of the 19 patients (57%) treated with rehabilitation were able to control the ejaculation reflex, with a mean IELT of 126.6 sec (range: 123.6-152.4 sec). In the dapoxetine group, after 12 weeks of therapy, 5 of 8 (62.5%) patients in the 30 mg subgroup and five of seven (72%) in the 60 mg subgroup had an IELT >180 sec (mean: 178.2 and 202.8 sec, respectively). The results obtained in the group treated with pelvic floor rehabilitation are promising, and this treatment represents an important cost reduction if compared to dapoxetine on-demand treatment. The present study confirms the data that are previously available in the literature on the efficacy and safety of the new inhibitor of serotonin reuptake, dapoxetine, as well as proposes and evaluates a new type of physical treatment that may be a viable therapeutic option for treatment of PE.
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Objective: To develop a contemporary, evidence-based definition of premature ejaculation (PE). Methods: There are several definitions of PE; the most commonly quoted, the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders - 4th Edition - Text Revision, and other definitions of PE, are all authority-based rather than evidence-based, and have no support from controlled clinical and/or epidemiological studies. Thus in August 2007, the International Society for Sexual Medicine (ISSM) appointed several international experts in PE to an Ad Hoc Committee for the Definition of PE. The committee met in Amsterdam in October 2007 to evaluate the strengths and weaknesses of current definitions of PE, to critically assess the evidence in support of the constructs of ejaculatory latency, ejaculatory control, sexual satisfaction and personal/interpersonal distress, and to propose a new evidence-based definition of PE. Results: The Committee unanimously agreed that the constructs which are necessary to define PE are rapidity of ejaculation, perceived self-efficacy, and control and negative personal consequences from PE. The Committee proposed that lifelong PE be defined as a male sexual dysfunction characterized by ejaculation which always or nearly always occurs before or within about one minute of vaginal penetration, and the inability to delay ejaculation on all or nearly all vaginal penetrations, and negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy. This definition is limited to men with lifelong PE who engage in vaginal intercourse. The panel concluded that there are insufficient published objective data to propose an evidence-based definition of acquired PE. Conclusion: The ISSM definition of lifelong PE represents the first evidence-based definition of PE. This definition will hopefully lead to the development of new tools and patient-reported outcome measures for diagnosing and assessing the efficacy of treatment interventions, and encourage ongoing research into the true prevalence of this disorder, and the efficacy of new pharmacological and psychological treatments.
Article
This study evaluated pelvic floor rehabilitation as a possible treatment for premature ejaculation. In this treatment it is assumed that the pelvic muscles are involved in the control of the ejaculatory reflex. The treatment avails itself of a method already used for fecal and urinary incontinence. Eighteen patients with premature ejaculation were recruited. Fifteen (83%) of them had suffered from this disturbance for at least five years. Most of them had experienced other therapies without success. After 15-20 sessions of pelvic floor rehabilitation, 11 (61%) patients were cured and are able to control the ejaculatory reflex; seven (39%) patients had no improvement. All patients were followed for a minimum of 6 months to a maximum of 14 months. This therapy is easy to perform, has no side effects, and can be included among the therapuetic options for patients with premature ejaculation.
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Urinary incontinence is a common condition caused by many factors with several treatment options. To compare the effectiveness of biofeedback-assisted behavioral treatment with drug treatment and a placebo control condition for the treatment of urge and mixed urinary incontinence in older community-dwelling women. Randomized placebo-controlled trial conducted from 1989 to 1995. University-based outpatient geriatric medicine clinic. A volunteer sample of 197 women aged 55 to 92 years with urge urinary incontinence or mixed incontinence with urge as the predominant pattern. Subjects had to have urodynamic evidence of bladder dysfunction, be ambulatory, and not have dementia. Subjects were randomized to 4 sessions (8 weeks) of biofeedback-assisted behavioral treatment, drug treatment (with oxybutynin chloride, possible range of doses, 2.5 mg daily to 5.0 mg 3 times daily), or a placebo control condition. Reduction in the frequency of incontinent episodes as determined by bladder diaries, and patients' perceptions of improvement and their comfort and satisfaction with treatment. For all 3 treatment groups, reduction of incontinence was most pronounced early in treatment and progressed more gradually thereafter. Behavioral treatment, which yielded a mean 80.7% reduction of incontinence episodes, was significantly more effective than drug treatment (mean 68.5% reduction; P=.04) and both were more effective than the placebo control condition (mean 39.4% reduction; P<.001 and P=.009, respectively). Patient-perceived improvement was greatest for behavioral treatment (74.1% "much better" vs 50.9% and 26.9% for drug treatment and placebo, respectively). Only 14.0% of patients receiving behavioral treatment wanted to change to another treatment vs 75.5% in each of the other groups. Behavioral treatment is a safe and effective conservative intervention that should be made more readily available to patients as a first-line treatment for urge and mixed incontinence.
Article
The medical literature contains several definitions of premature ejaculation (PE). The most commonly quoted definition, the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition-Text Revision, and other definitions of PE are all authority based rather than evidence based, and have no support from controlled clinical and/or epidemiological studies. The aim of this article is to develop a contemporary, evidence-based definition of PE. In August 2007, the International Society for Sexual Medicine (ISSM) appointed several international experts in PE to an Ad Hoc Committee for the Definition of Premature Ejaculation. The committee met in Amsterdam in October 2007 to evaluate the strengths and weaknesses of current definitions of PE, to critique the evidence in support of the constructs of ejaculatory latency, ejaculatory control, sexual satisfaction, and personal/interpersonal distress, and to propose a new evidence-based definition of PE. The committee unanimously agreed that the constructs that are necessary to define PE are rapidity of ejaculation, perceived self-efficacy and control, and negative personal consequences from PE. The committee proposed that lifelong PE be defined as ". . . a male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior to or within about one minute of vaginal penetration, and the inability to delay ejaculation on all or nearly all vaginal penetrations, and negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy." This definition is limited to men with lifelong PE who engage in vaginal intercourse. The panel concluded that there are insufficient published objective data to propose an evidence-based definition of acquired PE. The ISSM definition of lifelong PE represents the first evidence-based definition of PE. This definition will hopefully lead to the development of new tools and Patient Reported Outcome measures for diagnosing and assessing the efficacy of treatment interventions and encourage ongoing research into the true prevalence of this disorder and the efficacy of new pharmacological and psychological treatments.
Premature ejaculation. In: Human Sexual Inadequacy
  • Wh Masters
  • Ve Johnson
Masters WH, Johnson VE. Premature ejaculation. In: Human Sexual Inadequacy. Boston, Mass: Little Brown & Company. 1970; 92-115.
Premature ejaculation
  • W H Masters
  • V E Johnson
Masters WH, Johnson VE. Premature ejaculation. In: Human Sexual Inadequacy. Boston, Mass: Little Brown & Company. 1970;