ArticlePDF Available

Novos medicamentos homeopáticos: uso dos fármacos modernos segundo o princípio da similitude [New homeopathic medicines: use of modern drugs according to the principle of similitude]

Authors:
  • School of Medicine University of Sao Paulo
Article

Novos medicamentos homeopáticos: uso dos fármacos modernos segundo o princípio da similitude [New homeopathic medicines: use of modern drugs according to the principle of similitude]

Abstract

O método de tratamento homeopático se baseia na aplicação do princípio da similitude (similia similibus curentur), utilizando medicamentos que causam efeitos semelhantes aos sintomas da doença, com o objetivo de estimular uma reação do organismo contra seus próprios distúrbios. Essa reação vital, homeostática ou paradoxal do organismo está cientificamente embasada no estudo do efeito rebote das drogas modernas. Nesse trabalho, estamos concluindo uma proposta antiga, na qual sugerimos um método para a utilização homeopática das drogas modernas. Apoiados na justificativa epistemológica de que determinada classe de eventos adversos descritos na farmacologia experimental são sintomas patogenéticos das substâncias, foi elaborada uma Matéria Médica e um Repertório Homeopático com 1251 drogas modernas, sugerindo sua utilização segundo o princípio da similitude e a totalidade sintomática individualizante. Além de embasar a racionalidade homeopática perante a farmacologia científica, estamos disponibilizando uma metodologia que poderá ampliar o espectro de ação da homeopatia nas doenças atuais.
A preview of the PDF is not available
ResearchGate has not been able to resolve any citations for this publication.
Data
Full-text available
O método de tratamento homeopático se baseia na aplicação do princípio da similitude (similia similibus curentur), utilizando medicamentos que causam efeitos semelhantes aos sintomas da doença, com o objetivo de estimular uma reação do organismo contra seus próprios distúrbios. Essa reação vital, homeostática ou paradoxal do organismo está cientificamente embasada no estudo do efeito rebote das drogas modernas. Nesse trabalho estamos concluindo uma proposta antiga, na qual sugerimos um método para a utilização homeopática das drogas modernas. Apoiados na justificativa epistemológica de que determinada classe de eventos adversos descritos na farmacologia experimental são sintomas patogenéticos das substâncias, foi elaborada uma Matéria Médica e um Repertório Homeopático com 1.251 fármacos modernos, sugerindo sua utilização segundo o princípio da similitude e a totalidade sintomática individualizante. Além de embasar a racionalidade homeopática perante a farmacologia científica, estamos disponibilizando uma metodologia que poderá ampliar o espectro de ação da homeopatia nas doenças modernas (www.novosmedicamentoshomeopaticos.com).
Article
Full-text available
When Samuel Hahnemann systematized homeopathy and the effects of drugs on the state of human health, he described the primary action of drugs and the following secondary and opposite reaction of the organism. Seeking to apply this secondary action or vital reaction of the organism as therapeutic method, he postulated the principle of similitude, i.e. the prescription to ill individuals of drugs that cause similar symptoms in the healthy (similia similibus curentur). In modern pharmacology, secondary action (vital reaction) of drugs is known as rebound effect or paradoxical reaction of the organism. It has been observed after discontinuation of several classes of palliative (enantiopathic) drugs, namely those that act according to the principle of contraries (contraria contrariis curentur). Although in this case it is associated with severe and fatal iatrogenic events, rebound effect might awaken a healing reaction when the very same drug is employed according to the principle of similitude. The validity of the principle of similitude is proved by scientific evidence on rebound effect, whereas conventional drugs primary (therapeutic, adverse and side) effects might be equated to pathogenetic manifestations and thus be homeopathically applied. For this purpose a homeopathic materia medica and repertory comprising 1,251 modern drugs was elaborated using the monographs described in The United States Pharmacopeia Dispensing Information as source (www.newhomeopathicmedicines.com). Thus, the therapeutic range of homeopathy is broadened through the addition of hundreds of new medicines that might be employed in every kind of disease including countless modern clinical syndromes.
Article
Full-text available
The principle of the similitude, the basis of homeopathy, has correspondences in the clinical studies of secondary effects of many modern pharmaceutical agents through the observation of the rebound effects of these drugs. Through clinical pharmacology, I proposed a model on which to base the scientificism of the homeopathic model. We have studied the effects of the drugs in the human body using pharmacological compendia and recent scientific works, confirming the mechanism of the homeopathic medicines' action through the verification of the primary action of the drugs and the consequent secondary reaction of the organism in hundreds of pharmaceutical agents. Treatment exploiting the "rebound" effect (curative vital reaction) may also be observed. This work suggests a research methodology to scientifically base the therapeutic principle of similitude.
Article
Full-text available
Homeopathy is a therapeutic method based on the application of the similitude principle, utilising medicinal substances that produce effects that are similar to the symptoms being treated. In this process, the organism is stimulated to react against its own disturbances through a vital (paradoxical, secondary or homeostatic) reaction, oriented by the primary effect of the used drug. This effect should have properties that are similar to the symptom that is being treated. This secondary reaction of the organism to a medicinal stimulus is observed in hundreds of modern drugs, and is referred to as a rebound effect. In this study we propose the utilisation of modern drugs according to the principle of homeopathic cure, employing the rebound effect as a curative reaction. For that we suggest the compilation of a Common Materia Medica that would group all symptoms produced by the medications in human individuals (therapeutic, adverse and side effects), utilising them, a posteriori, following a partial or total similitude, in minimal or ponderous doses. By doing that, we can take advantage of the numerous modern pharmacological compendiums, amplifying the spectrum of homeopathic cure with a wide range of new symptoms and medications.
Article
Homeopathy is based on the principle of similitude (similia similibus curentur) using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism. Such vital, homeostatic or paradoxical reaction of the organism is closely related to rebound effect of drugs. Review of the literature concerning the rebound effects of drugs used to suppress gastric acidity, particularly proton pump inhibitors (PPIs). The mechanism of action of these effects is discussed. Rebound in terms of clinical symptoms and physiological effects occur in about 40% of people taking PPIs, their timing depends on the half-life of the drug and the adaptation period of the physiological mechanisms involved. The wide use of PPIs may be linked to the rising incidence of carcinoid tumours. These findings support Hahnemann's concept of secondary action of drugs. We are developing a homeopathic materia medica and repertory of modern drugs on the basis of reported rebound effects.
Article
Hahnemann considered the secondary action of medicines to be a law of nature and reviewed the conditions under which it occurs. It is closely related to the rebound effects observed with many modern drugs. I review the evidence of the rebound effect of statins that support the similitude principle. In view of their indications in primary and secondary prevention of cardiovascular diseases, statins are widely prescribed. Besides reducing cholesterol biosynthesis, they provide vasculoprotective effects (pleiotropic effects), including improvement of endothelial function, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory and thrombogenic responses, stabilisation of atherosclerotic plaques, and others. Recent studies suggest that suspension of statin treatment leads to a rebound imparing of vascular function, and increasing morbidity and mortality in patients with vascular diseases. Similarly to other classes of modern palliative drugs, this rebound effect is the same as a secondary action or vital reaction described by Samuel Hahnemann, and used in homeopathy in a therapeutic sense.
Article
Samuel Hahnemann noticed that palliative treatments for the symptoms of chronic diseases, after an initial improvement, provoked symptoms similar but stronger symptoms to those initially suppressed. He regarded this as a consequence of the vital reaction of the organism: an automatic and instinctive capacity to return to the initial health condition altered by medicines. Using this homeostatic conception of the organism as a treatment rationale, Hahnemann proposed the therapy of similarity, administering to the patients medicines capable of causing, in healthy individuals, similar symptoms to the natural disease. Based on experimental observations, he proposed that the primary action of the drug was followed by the secondary and opposite action of the organism, inaugurating homeopathic pharmacology, and alerting to the harmful consequences of palliative medicines in susceptible individuals. Such iatrogenic events can be observed in contemporary medicine, after the withdrawal of modern enantiopathic medicines, according to the study of the rebound effect or paradoxical reaction of the organism. This study reviews the recent studies which describe suicidality after the suspension or discontinuation of second generation antidepressants according to the hypothesis of the paradoxical reaction of the organism. Rebound and withdrawal effects, including suicidality occur with antidepressant drugs. They are relatively rare but more intense than the primary action of the drug. The probability of such effects is influenced by patient factors including age and diagnosis, and drug factors including half-life.
Article
WHO has developed Guidelines for Good Clinical Practice (GCP) for Trials on Pharmaceutical Products in order to establish globally applicable standards for the conduct of biomedical research on human subjects. A number of countries have no regulations for clinical trials or the regulations require supplementation. In those countries, the relevant health authority may designate, in part or in whole, the WHO GCP Guidelines as the basis on which clinical trials will be conducted. This article discusses the functions, obligations and responsibilities of the investigator as defined in the WHO GCP.
Article
Published in two volumes in 1805, Hahnemann's Latin work Fragmenta de viribus medicamentorum is the first materia medica in the history of homoeopathy. This article examines Hahnemann's use of his own published works in his early medical practice, by focusing on a single patient file from the medical casebooks.