Nanostructured Silica Materials As Drug-Delivery Systems for Doxorubicin: Single Molecule and Cellular Studies

Department of Chemistry and Biochemistry, Center for Nanoscience (CeNS) and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universitat Munchen, 81377 Munich, Germany.
Nano Letters (Impact Factor: 13.59). 08/2009; 9(8):2877-83. DOI: 10.1021/nl9011112
Source: PubMed


We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the widely used anticancer drug Doxorubicin. Through single-molecule based measurements, we gain mechanistic insights into the drug diffusion inside the mesoporous film, which governs the drug-delivery at the target-site. Drug dynamics inside the nanopores is controlled by pore size and surface modification. The release kinetics is determined and live-cell measurements prove the applicability of the system for drug-delivery. This study demonstrates that mesoporous silica nanomaterials can provide solutions for current challenges in nanomedicine.

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    • "However, it is highly toxic to the heart and kidneys, thereby limiting its application. Recently, a report of the release of DOX from mesoporous silica films has been described in cellular studies40. Therefore, systems which are able to administer such drug molecules in a controlled and sustained fashion would be very beneficial. "
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