Article

Consistent neuroanatomical age-related volume differences across multiple samples. Neurobiol Aging

Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Norway.
Neurobiology of aging (Impact Factor: 5.01). 07/2009; 32(5):916-32. DOI: 10.1016/j.neurobiolaging.2009.05.013
Source: PubMed

ABSTRACT

Magnetic resonance imaging (MRI) is the principal method for studying structural age-related brain changes in vivo. However, previous research has yielded inconsistent results, precluding understanding of structural changes of the aging brain. This inconsistency is due to methodological differences and/or different aging patterns across samples. To overcome these problems, we tested age effects on 17 different neuroanatomical structures and total brain volume across five samples, of which one was split to further investigate consistency (883 participants). Widespread age-related volume differences were seen consistently across samples. In four of the five samples, all structures, except the brainstem, showed age-related volume differences. The strongest and most consistent effects were found for cerebral cortex, pallidum, putamen and accumbens volume. Total brain volume, cerebral white matter, caudate, hippocampus and the ventricles consistently showed non-linear age functions. Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed.

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    • "As for from 80 years onwards, previous cross-sectional estimates of the associations between total cortical volume and age are, however, small and inconsistent relative to that observed in younger individuals, probably due to limited sample sizes (Jernigan et al., 2001;Walhovd et al., 2005;Walhovd et al., 2011). Relationship of hippocampal volume with age is found to be strong from 60 years onwards, and its magnitude has been found to be greater than that of the total cortical volume (Raz et al., 2004;Walhovd et al., 2011), in agreement with our results. Findings from the present study suggest that advanced age is associated with significantly smaller GM and hippocampal volumes, with a continuous age trend similar to that observed in the young elderly. "
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    • "Indeed, the cross-sectional approach is easier to implement, but it suffers from major flaws including potential cohort bias and the influence of elder individuals at the presymptomatic stage of a neurodegenerative disorder which may cause an overestimation of the age effect (Burgmans et al., 2009). The considered age range is also a source of heterogeneity between studies (Walhovd et al., 2011) as some studies evaluate the effect of age over the entire adult lifespan (Mueller et al., 2007, 2009; Che´telat et al., 2008; La Joie et al., 2010; Ziegler et al., 2011; Raz et al., 2014; Pereira et al., 2014; de Flores et al., 2015), while others only included elderly people (Wang et al., 2003, 2006; Frisoni et al., 2008; Apostolova et al., 2012; Khan et al., 2014; Wisse et al., 2014b). This point is particularly important as the effect of age on brain structures is known to be non-linear, with a strong regional specificity in the dynamic of the effects (Sowell et al., 2003; Fjell et al., 2014a,b). "
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    No preview · Article · Aug 2015 · Neuroscience
    • "As for from 80 years onwards, previous cross-sectional estimates of the associations between total cortical volume and age are, however, small and inconsistent relative to that observed in younger individuals, probably due to limited sample sizes (Jernigan et al., 2001;Walhovd et al., 2005;Walhovd et al., 2011). Relationship of hippocampal volume with age is found to be strong from 60 years onwards, and its magnitude has been found to be greater than that of the total cortical volume (Raz et al., 2004;Walhovd et al., 2011), in agreement with our results. Findings from the present study suggest that advanced age is associated with significantly smaller GM and hippocampal volumes, with a continuous age trend similar to that observed in the young elderly. "

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