Conversion from Calcineurin Inhibitors to Sirolimus Reduces Vascularization and Thickness of Post-transplant Cutaneous Squamous Cell Carcinomas

Hospices Civils de Lyon, Hôspital Edouard Herriot, Clinique Dermatologique (Pav. R), 69437 Lyon Cedex 03, France.
Anticancer research (Impact Factor: 1.83). 07/2009; 29(6):1927-32.
Source: PubMed


Immunosuppression favors the development of skin cancer. Experimental data suggest that sirolimus (SRL) has antitumoral and antiangiogenic properties. An investigation was undertaken into the effects of SRL on squamous cell carcinoma (SCC) developing in organ transplant recipients (OTR) receiving immunosuppressive treatments, with special emphasis on vascularization.
SCC that developed in eight OTR before and after conversion from calcineurin inhibitors (CNI) to SRL were compared for thickness, differentiation, ulceration, perineural invasion, density of peritumoral infiltrate, peritumoral vascularization, density of T-regulatory cells and of intratumoral Langerhans cells and growth fraction.
SCC developing under SRL showed lower peritumoral vascularization and thickness, and higher growth fraction and density of peritumoral T-regulatory cells.
Conversion from CNI to SRL at clinically relevant doses is associated in vivo with a reduced vascularization and thickness of post-transplant human cutaneous SCC. This effect could account for the beneficial effect of SRL on immunosuppression-induced skin carcinogenesis in humans.

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Available from: Jean Kanitakis, Mar 19, 2015
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    • "ese drugs exhibit antitumour activity via their inhibition of angiogenesis as well as cell cycle progression and growth. Rival-Tringali et al. demonstrated that switching from a CNI to sirolimus reduced vascularization and thickness of posttransplant human cutaneous SCC in vivo [22]. Following a recent meeting of pan- European dermatology experts, transplant physicians are being recommended to have recipients switched to these more protective, antineoplastic medications, particularly in patients with documented SCC [13]. "
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