... It is highly expressed in the lung, spleen, kidney and peripheral immune cells (neutrophils, monocytes and dendritic cells), while in the brain, there is a comparatively low level of LRRK2 expression [10][11][12]. In the cell, the protein is mainly cytoplasmic and prevalently associated with microtubules, endoplasmic reticulum and Golgi apparatus, trans-Golgi network (TGN), endosomes and lysosomes, where it has been linked to different processes, including cytoskeleton remodeling, neurite morphology, cell processes outgrowth, mitochondrial functions, protein synthesis, proteostasis, autophagy, vesicular trafficking and inflammation [13,14]. In the years several LRRK2 kinase substrates [9,[15][16][17][18][19] and binding partners have been identified [20][21][22][23][24]. Interestingly, many of these binding partners interact with the Roc domain, indicating ...