The Noether symmetries and conserved quantities for Birkhoffian systems with time delay are proposed and studied. First, the Pfaff–Birkhoff principle with time delay is proposed, and Birkhoff’s equations with time delay are obtained. Second, based on the invariance of the Pfaff action with time delay under a group of infinitesimal transformations, the Noether symmetric transformations and the Noether quasisymmetric transformations of the system are defined, and the criteria of the Noether symmetries are established. Finally, the relationship between the symmetries and the conserved quantities are studied, and the Noether theorems for Birkhoffian systems with time delay are established. Some examples are given to illustrate the application of the results.