抄録
Only a few studies have been done on mixing methods with mortars and pestles since many factors influence the mixing degree. Near-Infrared Spectroscopy (NIRS) is used to determine the composition of food and drugs in the U.S.A., Europe, and Japan. In order to evaluate its utility in establishing mortar and pestle mixing methods, we examined the effects of the number of mixings and filling
... [Show full abstract] factor on the mixing degree of ethenzamide and lactose, using NIRS and High Performance Liquid Chromatography (HPLC). Keeping the mixing ratio constant at 1:1 and varying the filling factor from 5% to 50%, and the number of mixings from 20-80, a relationship between the filling factor and the number of mixings, and the coefficient of variation as an index of mixing was examined.
A filling factor of 50% was found to be the optimum condition for mortar and pestle mixing methods. As the number of mixings increased, the coefficient of variation tended to decrease. NIRS was a more rapid and simple method of evaluation than HPLC, and there was no difference between NIRS and HPLC regarding ethenzamide concentration. These results suggested that measurement by NIRS is applicable in establishing optimum conditions for mixing pharmaceutical powders with mortars and pestles.
