Hemispheric asymmetry in cognitive division of anterior cingulate cortex: A resting-state functional connectivity study

Institute of Mental Health, Peking University, Beijing 100191, China.
NeuroImage (Impact Factor: 6.36). 07/2009; 47(4):1579-89. DOI: 10.1016/j.neuroimage.2009.05.080
Source: PubMed


The cognitive division of anterior cingulate cortex (ACC-cd) plays an important role in cognitive control via a distributed attention network. The structural hemispheric asymmetries of ACC have been revealed by several neuroimaging studies. However potential functional hemispheric asymmetries of ACC remain less clear. Investigating the functional hemispheric asymmetries of ACC helps for a better understanding of ACC function. The aim of this study was to use resting-state functional magnetic resonance imaging (fMRI) to examine hemispheric differences in the functional networks associated with ACC-cd in the two hemispheres. ROI-based functional connectivity analysis was performed on a group of 49 right-handed healthy volunteers. The left and right ACC-cd showed significant differences in their patterns of connectivity with a variety of brain regions, including the dorsolateral prefrontal cortex, inferior parietal lobule, superior parietal lobule and dorsal posterior cingulate cortex in their ipsilateral cerebral cortex, as well as cerebellar tonsil and inferior semilunar lobule in their contralateral cerebellar hemisphere. Specifically, for these areas, we found significantly greater connectivity strength with ACC-cd in the right hemisphere than the left, regardless of whether the connection was positive or negative. The current results highlight the presence of clear asymmetries in functional networks associated with ACC-cd. Future functional imaging studies are needed to give greater attention to the lateralized ACC functional networks which are observed.

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Available from: Yu-Feng Zang, May 19, 2015
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    • "In addition, anatomical tracing studies performed in rhesus monkeys point out neurons in the ACC project to the ventral striatum (Selemon and Goldman-Rakic, 1985). Emerging evidences revealed that DA levels, gray matter volume for ACC and rs-FC strength with ACC in the right hemisphere were greater than the left (Afonso et al., 1993; Paus et al., 1996; Huster et al., 2007; Yan et al., 2009; Watanabe et al., 2015). Hence, functional connectivity with the right ACC might be sensitive to slight changes in DA levels, which our research indicates are regulated by the interaction of the BDNF and COMT genes. "
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    ABSTRACT: The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine in the ventral striatum, while catechol-O-methyltransferase (COMT) impacts dopamine availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the dopamine-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral ventral striatum (VST) and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-relationship in COMT Met carriers, while COMT Val homozygotes displayed a U-relationship. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
    Full-text · Article · Apr 2015 · Neuroscience
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    • "For example, Fornito et al. [2004] found that leftward asymmetry of paracingulate sulcus was associated with better performance on both verbal and spatial tasks. This may be attributed to the underlying hemispheric differences in cortical thickness [Fornito et al., 2008] and functional interactions [Yan et al., 2009] within prefrontal regions. In addition to the normal asymmetries, some neurologic diseases also showed lateralized pathologies between two hemispheres [Koziol et al., 2005; Muhlau et al., 2007]; and disturbances in structural or functional brain asymmetries have been detected in psychotic disorders, such as schizophrenia [Kawasaki et al., 2008; Narr et al., 2001; Takao et al., 2010a; Zhou et al., 2003] and bipolar disorder [Reite et al., 1999]. "
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    ABSTRACT: White matter (WM) asymmetries of the human brain have been well documented using diffusion tensor imaging (DTI). However, the relationship between WM asymmetry pattern and cognitive performance is poorly understood. By means of tract-based spatial statistics (TBSS) and voxel-based analyses of whole brain, this study examined the WM asymmetries and the correlations between WM integrity/asymmetries and three distinct components of attention, namely alerting, orienting, and executive control (EC), which were assessed by attention network test (ANT). We revealed a number of WM anisotropy asymmetries, including leftward asymmetry of cingulum, corticospinal tract and cerebral peduncle, rightward asymmetry of internal capsule, superior longitudinal fasciculus and posterior corona radiata, as well as heterogeneous asymmetries in anterior corpus callosum and anterior corona radiata (ACR). Moreover, specific correlation was found between asymmetric pattern of inferior frontal ACR and EC performance. Additionally, this study also proposed that there were no significant relationships of WM anisotropy asymmetries to alerting and orienting functions. Further clusters of interest analyses and probabilistic fiber tracking validated our findings. In conclusion, there are a number of differences in WM integrity between human brain hemispheres. Specially, the anisotropy asymmetry in inferior frontal ACR plays a crucial role in EC function. Our finding is supportive of the functional studies of inferior frontal regions and in keeping with the theory of the brain lateralization on human ventral attention system. Hum Brain Mapp, 2011. © 2011 Wiley Periodicals, Inc.
    Full-text · Article · Apr 2013 · Human Brain Mapping
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    • "Using this method, Allen et al. [94] found that activity in the dentate nucleus of the cerebellum correlated with changes in activity in non-motor regions such as the limbic system, parietal lobes, and prefrontal cortex. Connectivity between the cerebellum and anterior cingulate cortex, a region typically associated with error detection, anticipation, attention, and emotional responses, has also been reported in resting state paradigms [95]. Furthermore, there is evidence that the cerebellum contributes to the intrin‐ sic connectivity networks, a series of brain structures that correspond to basic functions such as vision, audition, language, episodic memory, executive functioning, and salience detec‐ tion [11]. "

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