International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation

Divisione di Ematologia dell'Università di Torino, Azienda Ospedaliera S. Giovanni Battista, Ospedale Molinette, Torino 10126, Italy.
Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K (Impact Factor: 10.43). 07/2009; 23(10):1716-30. DOI: 10.1038/leu.2009.122
Source: PubMed


In 2005, the first guidelines were published on the management of patients with multiple myeloma (MM). An expert panel reviewed the currently available literature as the basis for a set of revised and updated consensus guidelines for the diagnosis and management of patients with MM who are not eligible for autologous stem cell transplantation. Here we present recommendations on the diagnosis, treatment of newly diagnosed non-transplant-eligible patients and the management of complications occurring during induction therapy among these patients. These guidelines will aid the physician in daily clinical practice and will ensure optimal care for patients with MM.

  • Source
    • "According to the International Myeloma Working Group guidelines, MM-related neoplastic conditions have been categorized into monoclonal gammopathy of undetermined significance (MGUS), smoldering (asymptomatic) myeloma (SMM), solitary plasmacytoma of bone, and symptomatic multiple myeloma [6]. Diagnosed symptomatic multiple myeloma falls into one of three stages, IB, II, or IIIA/B, whereas SMM is identified as stage IA myeloma as determined by Durie/Salmon staging [6]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose Whether patients with smoldering multiple myeloma (SMM) needed to receive early interventional treatment remains controversial. Herein, we conducted a meta-analysis comparing the efficacy and safety of early treatment over deferred treatment for patients with SMM. Methods MEDLINE and Cochrane Library were searched to May 2014 for randomized controlled trials (RCTs) that assessed the effect of early treatment over deferred treatment. Primary outcome measure was mortality, and secondary outcome measures were progression, response rate, and adverse events. Results Overall, 5 trials including 449 patients were identified. There was a markedly reduced risk of disease progression with early treatment (Odds Ratio [OR] = 0.13, 95% confidence interval [CI] = 0.07 to 0.24). There were no significant differences in mortality and response rate (OR = 0.85, 95% CI = 0.45 to 1.60, and OR = 0.63, 95% CI = 0.32 to 1.23, respectively). More patients in the early treatment arm experienced gastrointestinal toxicities (OR = 10.02, 95%CI = 4.32 to 23.23), constipation (OR = 8.58, 95%CI = 3.20 to 23.00) and fatigue or asthenia (OR = 2.72, 95%CI = 1.30 to 5.67). No significant differences were seen with the development of acute leukemia (OR = 2.80, 95%CI = 0.42 to 18.81), hematologic cancer (OR = 2.07, 95%CI = 0.43 to 10.01), second primary tumors (OR = 3.45, 95%CI = 0.81 to 14.68), nor vertebral compression (OR = 0.18, 95%CI = 0.02 to 1.59). Conclusions Early treatment delayed disease progression but increased the risk of gastrointestinal toxicities, constipation and fatigue or asthenia. The differences on vertebral compression, acute leukemia, hematological cancer and second primary tumors were not statistically significant. Based on the current evidence, early treatment didn’t significantly affect mortality and response rate. However, further much larger trials were needed to provide more evidence.
    Full-text · Article · Oct 2014 · PLoS ONE
  • Source
    • "Patients were recruited from two tertiary care hospitals in Athens: Evangelismos General Hospital and Alexandra General Hospital. It is noteworthy that the latter is a reference point in Greece for treating MM and has participated in many international research protocols [21] [22] [23] [24]. Subjects were approached during a scheduled visit to one of the hospitals. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Objectives: The aim of this study was to assess the psychometric properties of the Greek EORTC QLQ-C30 and QLQ-MY20 instruments. Method: A sample of myeloma patients (N = 89) from two tertiary hospitals were surveyed with the QLQ-C30, QLQ-MY20 and various demographic and disease related questions. The previously validated Greek SF-36 instrument was used as a "gold standard" for health-related quality of life (HRQoL) comparisons. Hypothesized scale structure, internal consistency reliability (Cronbach's alpha) and various forms of construct validity (convergent, discriminative, concurrent and known-groups) were assessed. Results: Multitrait scaling confirmed scale structure of the QLQ-C30 and QLQ-MY20, with good item convergence (96% and 72%) and discrimination (78% and 58%) rates. Cronbach's α was >0.70 for all but one scale (cognitive functioning). Spearman's correlations between similar QLQ-C30 and SF-36 scales ranged between 0.35-0.80 (P < 0.001). Expected interscale correlations and known-groups comparisons supported construct validity. QLQ-MY20 scales showed comparatively lower correlations with QLQ-C30 functional scales, and higher correlations with conceptually related symptom scales. Conclusions: The observed psychometric properties of the two instruments imply suitability for assessing myeloma HRQoL in Greece. Future studies should focus on generalizability of the results, as well as on specific issues such as longitudinal validity and responsiveness.
    Full-text · Article · Aug 2012 · The Scientific World Journal
  • [Show abstract] [Hide abstract]
    ABSTRACT: This chapter discusses the catalytic properties of MFI zincosilicates. A series of zincosilicates MFI is synthesized from the mixtures of even zinc/silicon (Zn/Si) ratio and various silicon sources. The properties of the resulting samples differed considerably regarding their zinc content, the crystallite morphology, and size and catalytic activity. The samples modified with various cations show some activity for 2-propanol dehydration. The samples modified with aluminium (Al) cations shows the highest activity. It is likely that part of Al could attain the framework positions or facilitate a generation of separated acidic hydroxyl (OH) groups. The lower activity of the H-forms could result from the presence of hydrogen bonds among adjacent hydroxyls.
    No preview · Article · Dec 2001 · Studies in surface science and catalysis
Show more