Safety of efavirenz in the first trimester of pregnancy: An updated systematic review and meta-analysis

AIDS (London, England) (Impact Factor: 5.55). 03/2014; 28 Suppl 2:S123-31. DOI: 10.1097/QAD.0000000000000231
Source: PubMed


Primate studies and some observational human data have raised concern regarding an association of first-trimester efavirenz exposure with central nervous system congenital anomalies. The objective of this review is to update evidence on efavirenz safety in HIV-infected pregnant women to inform revision of the 2013 WHO guidelines for antiretroviral therapy in low and middle-income countries.

Download full-text


Available from: Zara Shubber, Jun 12, 2014
Show more