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Estudio preclínico del efecto de las esencias florales de Bach en la inflamación aguda

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Introducción: los estudios preclínicos que de forma habitual preceden al uso de un medicamento convencional pudieran convertirse en la solución a la comprobación de las acciones terapéuticas de medicinas naturales como las flores de Bach. La inflamación aguda y los modelos experimentales que la simulan son herramientas útiles en este camino. Objetivo: evaluar la actividad antiinflamatoria de las esencias florales de Bach en un modelo de inflamación aguda en ratas. Métodos: se realizó un estudio preclínico experimental piloto controlado y aleatorizado a ciegas en la UTEX de la Universidad de Ciencias Médicas de Villa Clara en el mes de Diciembre del 2010. El modelo experimental consistió en la inducción de edema plantar con dextrán. Se conformaron en 5 grupos de 6 animales (en total 30 ratas). Se trataron con las esencias Beech, Vervain y Rescue Remedy, respectivamente; mientras que los 2 restantes fueron control (negativo con placebo y positivo con Difenhidramina). Resultados: se observaron diferentes efectos en los tratamientos utilizados. Beech y Vervain mostraron propiedades antiinflamatorias con diferencias significativas al placebo, cuestión que avala su utilización en el tratamiento de patologías donde la inflamación es un denominador común. Estas acciones fueron selectivas ya que Beech tuvo efecto inmediato y Vervain mostró actividad sobre la inflamación en tercera hora. Otro preparado, el Rescue Remedy, no mostró esta actividad diferente al placebo.
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... Edward Bach usó preparaciones altamente diluidas de muchas especies derivadas de flores silvestres para ayudar a las personas a recuperar su salud. Este tema fue muy controvertido, pero esta terapia podría ser apoyada por el nuevo conocimiento sobre las nanopartículas y sus efectos en los sistemas vivos, en vez de serlo por alguna "energía curativa desconocida" (Rivas Suárez, Valido Díaz, & Blanco Machado, 2013). ...
Technical Report
En el año 2014 la Organización Mundial de la Salud publicó su nueva estrategia para la medicina tradicional y complementaria 2014-2023 marcada por tres objetivos principales: el desarrollo de una base de conocimientos y formulación de políticas nacionales; el fortalecimiento de la seguridad, la calidad y la eficacia mediante la reglamentación, y el fomento de la cobertura sanitaria universal por medio de la integración de servicios y la autoatención de salud en los sistemas nacionales de salud. Conscientes de esta situación y del debate que sigue generando la práctica y utilización de las terapias naturales y complementarias en nuestro contexto, en el año 2016 el Col·legi d’Infermeres i Infermers de Barcelona encargó al grupo de Investigación en Cuidados de la Salud (GRECS) del Instituto de Investigación Biomédica de Lleida la actualización de la guía con el fin de proporcionar una herramienta más amplia -incluyendo en esta ocasión terapias- que recogiera las mejores evidencias actualmente disponibles que demuestran los posibles efectos beneficiosos del uso de las terapias naturales y complementarias en las ciencias de la salud. Por supuesto, no en todas las terapias que se incluyen en la guía se han descrito dichos efectos y así también queda reflejado en el apartado de resultados, donde se describen tanto aquellas terapias que bien precisan de mayor evidencia científica, o bien aquellas que no aportan ningún beneficio para sus usuarios con los estudios actualmente disponibles. En definitiva, se trata de proporcionar conocimiento sobre las terapias naturales y complementarias de manera que su integración en los planes de estudio y en los sistemas de salud se realice de forma segura, eficaz y con la calidad necesaria.
... There are 38 essences prepared with a therapeutic purpose and property intended to balance emotional problems, harmonizing the person with the environment in which they live. 14,15 This research proves to be relevant for seeking an answer to the problem of teachers' stress, anchored in a theoretical model that clarifies the problem and systematizes its service. ...
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Objective: to evaluate the effectiveness of Bach flower essences in reducing teachers' stress levels. Method: a controlled, randomized, and double-blind clinical trial with a prospective design. In data collection, a form validated in the light of Betty Neuman's theory and another three instruments were used, one in the perceptive perspective (PSS-14), the second in the prevalence of the signs and symptoms (LSS), and the third for the evaluation of the bio-electrographic aspects (FAAB). The sample consisted of 27 teachers from the basic education network, with medium and high levels of stress and divided into two groups: intervention group (IG), the one that received Bach flower essences, and placebo group (PG). Results: the IG proved to be effective in reducing stress, being statistically significant intra-group with the decrease in the mean scores of PSS-14 (p=0.004), LSS (p=0.000), and bioelectrography (p=0.011); as well as between groups with a p-value of 0.035 for LSS, and FAAB with p=0.001. Conclusion: the Bach flower essences proved to be effective in the care of teachers' stress with the re-structuring of the flexible line of defense, reflecting in a better relationship between the teacher and intra-, inter-, and extra-personal stressors. This study is registered in the ReBEC under UTN Nº U1111-1208-4987.
... Systematic reviews agree that BFR are essentially a placebo (11)(12)(13); even more, a useful one (12,(14)(15)(16). It is important to highlight that although recent studies have shown specific effects (17)(18)(19)(20)(21)(22) we consider the majority of responses to BFR in clinical practice as a broad collection of spurious therapeutic effects (23). ...
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Background: We present two studies (hereafter Study 1 and Study 2), aimed to evaluate Bach Flower Remedies (BFR) effectiveness in controlling food cravings (FC), with assessment at three different stages: baseline, 1 month after baseline and 3 months after baseline. Methods: Study 1 consisted in a double-blind placebo-controlled trial aimed to assess the specific effects of a BFR-formula and the overall effectiveness of the placebo-control on FC (n=173). Participants were assigned to BFR (n=65), Placebo (n=55) and Control group (n=53). On the other hand, Study 2 did not involve deception, and combined an implementation intention instruction with the BFR-formula, all aimed to reduce FC in overweight and obese adults while at home (n=74). Every participant received an implementation intention instruction to sip a glass of water whenever experiencing FC at home. BFR group (n=37) was instructed to sip water with BFR solution diluted in it, whereas Water group just sipped plain water (n=37). Results: Study 1 did not support specific effects for BFR; placebo seemed to be effective in controlling FC. Moreover, findings from Study 2 suggest that BFR, used at least once a day, in conjunction with implementation intention intervention, may be helpful in reducing FC in overweight and obese adults while at home. Conclusions: Results of both Studies helped us evaluate the ‘power of the placebo’ in helping individuals overcome FC in their everyday life.
... 54 Fortunately, there is new evidence that supports the idea that BFR may have specific effects. [9][10][11][12] This study was also limited due to consideration of shortterm effects. Further research is recommended to determine the long-term outcomes and comparison of BFR creams with other conservative managements of CTS. ...
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Background: A randomized, pilot, placebo-controlled clinical trial was conducted with the aim of evaluating the effectiveness of a cream based on Bach flower remedies (BFR) on symptoms and signs of carpal tunnel syndrome. Methods: Forty-three patients with mild to moderate carpal tunnel syndrome during their "waiting" time for surgical option were randomized into 3 parallel groups: Placebo (n = 14), blinded BFR (n = 16), and nonblinded BFR (n = 13). These groups were treated during 21 days with topical placebo or a cream based on BFR. Results: Significant improvements were observed on self-reported symptom severity and pain intensity favorable to BFR groups with large effect sizes (η(2) partial > 0.40). In addition, all signs observed during the clinical exam showed significant improvements among the groups as well as symptoms of pain, night pain, and tingling, also with large effect sizes (φ > 0.5). Finally, there were significant differences between the blinded and nonblinded BFR groups for signs and pain registered in clinical exam but not in self-reports. Conclusion: The proposed BFR cream could be an effective intervention in the management of mild and moderate carpal tunnel syndrome, reducing the severity symptoms and providing pain relief.
Conference Paper
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Background and Objective This study evaluates the efficacy and safety of a sufentanil sublingual tablet system (SSTS) for the management of postoperative pain following open abdominal surgery (1). Based on the results of three phase III studies, the SSTS has been approved in the EU for the management of acute moderate to severe postoperative pain in adults in a hospital setting. Methods Patients undergoing major abdominal surgery were included from the General Surgical Unit of the Regina Apostolorum Hospital. Patients following surgery with pain intensity of greater than 4 and smaller than 8 on an 11-point numerical rating scale were randomized to receive SSTS dispensing a 15-μg sufentanil tablet sublingually with a 20-minute lockout. Elegible patients met the following criteria: adults older than 18 yr scheduled for major abdominal surgery, ASA 1-3, general anaesthesia or spinal anahestesia (without using intratecal opioids); Exclusion criteria included : ASA ˃ 3, patients with OSAS, or unable to understand the use of SSTS, patients with story of alcoholism or drug dependence. Patients were observed at regular intervals during a 72-hour evaluation period. Numeric Rating Scale ( NRS ) scores were used to assess analgesia and satisfaction with therapy. The primary end point was time-weighted summed pain intensity difference (SPID) over 48 hours. Secondary end points included SPID and total pain relief (TOTPAR) for up to 72 hours and patient and health care provider global assessments of the method of pain control. Results The SSTS was associated with a more rapid onset of analgesia and higher rates of success, based on patient and healthcare professional global assessments of the method of pain control. The SSTS was generally well tolerated, safety parameters, vital signs and adverse event profile typical of that of other opioids and generally similar to that of placebo. Conclusions These results suggest that SSTS is effective and safe for the management of postoperative pain in patients following open abdominal surgery. By virtue of its preprogrammed, noninvasive design, the SSTS avoids the risk of pump programming errors and other complications (e.g. infections and analgesic gaps) that can occur with IV-PCA technology; it also imposes less restriction on postoperative mobility.
Conference Paper
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Background and Objective This study evaluates the efficacy and safety of a sufentanil sublingual tablet system (SSTS) for the management of postoperative pain following open abdominal surgery (1). Based on the results of three phase III studies, the SSTS has been approved in the EU for the management of acute moderate to severe postoperative pain in adults in a hospital setting. Methods Patients undergoing major abdominal surgery were included from the General Surgical Unit of the Regina Apostolorum Hospital. Patients following surgery with pain intensity of greater than 4 and smaller than 8 on an 11-point numerical rating scale were randomized to receive SSTS dispensing a 15-μg sufentanil tablet sublingually with a 20-minute lockout. Elegible patients met the following criteria: adults older than 18 yr scheduled for major abdominal surgery, ASA 1-3, general anaesthesia or spinal anahestesia (without using intratecal opioids); Exclusion criteria included : ASA ˃ 3, patients with OSAS, or unable to understand the use of SSTS, patients with story of alcoholism or drug dependence. Patients were observed at regular intervals during a 72-hour evaluation period. Numeric Rating Scale ( NRS ) scores were used to assess analgesia and satisfaction with therapy. The primary end point was time-weighted summed pain intensity difference (SPID) over 48 hours. Secondary end points included SPID and total pain relief (TOTPAR) for up to 72 hours and patient and health care provider global assessments of the method of pain control. Results The SSTS was associated with a more rapid onset of analgesia and higher rates of success, based on patient and healthcare professional global assessments of the method of pain control. The SSTS was generally well tolerated, safety parameters, vital signs and adverse event profile typical of that of other opioids and generally similar to that of placebo. Conclusions These results suggest that SSTS is effective and safe for the management of postoperative pain in patients following open abdominal surgery. By virtue of its preprogrammed, noninvasive design, the SSTS avoids the risk of pump programming errors and other complications (e.g. infections and analgesic gaps) that can occur with IV-PCA technology; it also imposes less restriction on postoperative mobility.
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Background Several surgical procedures are performed every day around the world, most of them are discomfortable for patients. Some diagnostic procedures or short surgical interventions may be performed with local anesthesia. A ‘short’ procedure may be described as an intervention anticipated to take less than 60 minutes. Local anesthesia offers an indisputable advantage regarding the pain control with minimal systemic side-effects and good patient tolerability. Tramadol is an atypical synthetic opioid analgesic. It is considered a weak opioid due to its relatively low affinity for μ-opioid receptor [1]. Tramadol and its active metabolite bind to μ-opioid receptors in the central nervous system resulting in inhibition of ascending pain pathways and also inhibits the reuptake of norepinephrine and serotonin, involved in the descending inhibitory pain pathway, associated with pain relief [2]. In addition, tramadol has been proved to exert a local anesthetic effect on peripheral nerves in both clinical and laboratory studies. The mechanism of action of tramadol is similar to that of hydrophobic local anesthetics [3]. Methods A systematic review of the literature will be conducted following the PRISMA guidelines [4]. Either randomized controlled trials and observational studies, in which Tramadol is locally administrated, will be included. The search will be made using several electronic database: PubMed, EMBASE, CENTRAL and The JBI Database of Systematic Review and Implementation Report (JBISRIR). The intervention will be the local administration of Tramadol alone or as adjuvant to other anesthetics used for pain control. The comparison will be: 1. Placebo 2. No treatment 3. Standard local anesthetic-based therapy according to current guidelines. The primary outcome will be the pain control as: i) pain intensity reduction of at least 2, 3 or 4 points or by achieving a VAS score < 3 and/or ii) pain intensity reduction of at least 2, 3 or 4 points or by achieving a NRS score < 3[5] The secondary outcomes will be the: A. drugs consumption as A1. reduction of tramadol rescue dose and/or A2. reduction of others analgesic drugs consumption B. alterated vital signs as B1. tachycardia (heart rate > physiological range by age) and/or B2. hypertension (blood pressure > physiological range by age) and/or B3. desaturation (SpO2 < physiological range by age) Inclusion criteria of the enrolled studies will be: i) clear description of local tramadol administration ii) publication in peer-reviewed journals iii) English language iv) published in full Exclusion criteria: i) studies describing the tramadol uses for no surgical procedures ii) letter/comment, case report/series, systematic/narrative reviews, abstract, book chapter iii) pre-procedural or peri-procedural intravenous use of tramadol iv) intrathecal or troncular injection of tramadol. Discussion The aim of this systematic review is to investigate the effectiveness of local administration of tramadol for post-procedural pain control in order to reduce side-effects related to the systemic administration of analgesic drugs and reduce patient’s discomfort. This systematic review will be conducted in accordance with the Centre of Reviews and Dissemination (CRD) guidance for undertaking reviews in health care and registered on the PROSPERO Registry of systematic reviews: CRD4201808738.
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An experimental double blind controlled study was carried out to confirm the effectiveness of the so-called "Bach flower essences" in the improvement of memory functions. To this end, a five flower mixture (Chesnut, Bud, Red Chesnut, Wild Oat, Honey Suckle and Clematis) obtained from homeopathic drugstore located in Havana was administered to first-year university students at the University of Havana. Three groups were created, one without treatment and the two other groups received 4 daily doses for 10 days at a rate of 4 drops sublingually of the flower mixture or the placebo in which flower are prepared and preserved. To assess the effect, a memory test (Rey´s test) was applied to the participants in the subsequent days. The first day, they were given a list of 15 words and the number of correct words that they were able to remember immediately was recorded in writing. This method was repeated 5 times; there was a progressive increase in the number of correct words remembered. On the following day, they were given some cartoon story containing among other the 15 words from the list and the participants were asked to identify them. The Statistical analysis (ANOVA) of the results did not show significant differences among the groups in none of the tests. These results did not support the hypothesis that these flower mixtures have a real impact and suggested that their possible success in some cases be of placebo-type.
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Bach® Original Flower Essence (BFE) Rescue® Remedy, a modality used since 1930 but not yet thoroughly investigated scientifically, was evaluated for the reduction of acute situational stress. A double-blind clinical trial comparing a standard dosage of BFE Rescue Remedy against a placebo of identical appearance was conducted in a sample of 111 individuals aged 18 to 49, randomized into treatment (n = 53) and control (n = 58) groups. The Spielberger State-Trait Anxiety Inventory (STAI) was administered before and after the use of Rescue Remedy or placebo. Downward trends in anxiety level measurements were discovered in both the treatment (Rescue Remedy) and control (placebo) groups. Statistical analyses indicated that only the high-state anxiety treatment subgroup demonstrated a statistically significant difference between pretest and posttest scores. The results suggest that BFE Rescue Remedy may be effective in reducing high levels of situational anxiety.
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Bach Flower Remedies are thought to help balance emotional state and are commonly recommended by practitioners for psychological problems and pain. We assessed whether Bach Flower Remedies (BFRs) are safe and efficacious for these indications by performing a systematic review of the literature. We searched MEDLINE, Embase, AMED, and the Cochrane Library from inception until June 2008 and performed a hand-search of references from relevant key articles. For efficacy, we included all prospective studies with a control group. For safety, we also included retrospective, observational studies with more than 30 subjects. Two authors abstracted data and determined risk of bias using a recognised rating system of trial quality. Four randomised controlled trials (RCTs) and two additional retrospective, observational studies were identified and included in the review. Three RCTs of BFRs for students with examination anxiety, and one RCT of BFRs for children with attention-deficit hyperactivity disorder (ADHD) showed no overall benefit in comparison to placebo. Due to the number and quality of the studies the strength of the evidence is low or very low. We did not find any controlled prospective studies regarding the efficacy of BFRs for pain. Only four of the six studies included for safety explicitly reported adverse events. Most of the available evidence regarding the efficacy and safety of BFRs has a high risk of bias. We conclude that, based on the reported adverse events in these six trials, BFRs are probably safe. Few controlled prospective trials of BFRs for psychological problems and pain exist. Our analysis of the four controlled trials of BFRs for examination anxiety and ADHD indicates that there is no evidence of benefit compared with a placebo intervention.
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There is a background for use of oily extract with purified butter of Zingiber officinale Roscoe in treatment of allergic diseases and of airways by Mexican people; also, tasks performed in our lab demonstrated a protective effect of it in case of bronchospasm provoked by hystamines, and in experimental cutaneous passive anaphylaxis. Since these results anti-inflammatory assessment of such extract was made in induction models of plantar edema in rat, using different flogistic agents as Dextran, Histamine, Serotonine, and Carragenine. Rats received oleic extract of Zingiber officinale Roscoe by oral route, at a dosis of 6,5 mL/kg of body weight, one hour before induction of plantar edema, also we assessed Cyproheptadine, Diphenhydramine and Indomethacin as positive controls. Statistical analysis showed that administration of oleic extract of Zingiber officinalie Roscoe produces a significant inhibition (p
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Bach flower remedies continue to be popular and its proponents make a range of medicinal claims for them. The aim of this systematic review was to critically evaluate the evidence for these claims. Five electronic databases were searched without restrictions on time or language. All randomised clinical trials of flower remedies were included. Seven such studies were located. All but one were placebo-controlled. All placebo-controlled trials failed to demonstrate efficacy. It is concluded that the most reliable clinical trials do not show any differences between flower remedies and placebos.
The aim of this randomized, double-blind, placebo-controlled trial was to investigate the efficacy of ‘Five Flower Remedy’® also known as Rescue Remedy®, for examination anxiety in healthy university students. One hundred university students were recruited. They were registered at the University of Exeter, aged between 18 to 65 years, and enrolled to undertake university examinations between May to July 1998. Participants were randomized to take one to four doses of either ‘Five Flower Remedy’ or indistinguishable placebo during day 1 to 7 of the experiment. Self-reported anxiety was quantified using the 40-item Spielberger State-Trait Anxiety Inventory (STAI) as the primary outcome measure. Visual analogue scales were used as the secondary outcome measure to allow the determination of daily anxiety scores. Forty five percent of volunteers completed the study (21 subjects in the experimental and 24 in the placebo group). Reporting of anxiety, as measured by the state component of the STAI at enrolment, was not found to differ between verum and placebo and no gender differences were noted. However, self-reports of trait anxiety were found to be lower in men compared to women at enrolment. Eight days before examination, men reported significantly lower levels of state anxiety but no significant differences were subsequently identified the evening before the examination. No significant differences were identified between or within groups for mean values of the daily VAS scores or indeed the linear contrast variable constructed to determine any trends associated with the weekly VAS reports. It is concluded that ‘Five Flower Remedy’ had no specific effects in treating anxiety under these trial conditions.
Manual de Aplicaciones Locales
  • R Orozco
  • Flores De
  • Bach
Orozco R. Flores de Bach. Manual de Aplicaciones Locales. Ed. Indigo: Barcelona; 2003.
Modelos de inflamación aguda en ratas: un estudio aleatorizado y controlado sobre los efectos de los remedios homeopáticos. BMC Medicina Complementaria y Alternativa
  • A Conforti
  • P Bellavite
  • B Simone
  • C Flavia
  • F M Hipólito
  • R Roberto
Conforti A, Bellavite P, Simone B, Flavia C, Hipólito FM, Roberto R. Modelos de inflamación aguda en ratas: un estudio aleatorizado y controlado sobre los efectos de los remedios homeopáticos. BMC Medicina Complementaria y Alternativa, 2007. 7: 1. Disponible en: http://viaclinica.com/journal.php?abbr=BMC+Complement+Altern+Med&page=1. Recibido: 13/1/2012