Article

Standard parameters on initial echocardiograph cannot predict cardiotoxicity caused by trastuzumab

Authors:
Ivo Darko Gabric at Sisters of Charity Hospital Zagreb
Ivo Darko Gabric
Vazdar Lj
Vazdar Lj
Vazdar Lj
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Hrvoje Pintaric at University of Zagreb
Hrvoje Pintaric
Danijel Planinc
Danijel Planinc
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... Najčešće se javlja kao reverzibilna disfunkcija miokarda te često nakon privremenog prekida terapije dolazi do oporavka srčane funkcije i moguć je nastavak onkološkog liječenja. [1][2][3] Pacijenti i metode: Od početka 2009. do kraja 2015. ...
... Temporary cessation of therapy often leads to recovery of cardiac function, and it is possible to continue the oncology treatment. [1][2][3] Patients and Methods: Since the beginning of 2009 until the end of 2015, we have analyzed 496 patients (pts) with non-metastatic breast cancer, treated with trastuzumab for one year with the standard adjuvant therapy protocol. Cardiotoxicity was defined with the reduction of left ventricular ejection fraction (LVEF) by 15% from the baseline or by 10% of normal values. ...
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