Divergent Picobirnaviruses in Human Feces

Genome Announcements 05/2014; 2(3). DOI: 10.1128/genomeA.00415-14
Source: PubMed


The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D
and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to
known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted
by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest
of ORF2.

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Available from: Jan Vinjé, Jun 17, 2014
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