Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

JAMA Internal Medicine (Impact Factor: 13.12). 05/2014; 174(7). DOI: 10.1001/jamainternmed.2014.1582
Source: PubMed


Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.Objective
To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.Design
Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.Exposures
Twenty-four–hour urinary resveratrol metabolites.Main Outcomes and Measures
Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.Results
Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.Conclusions and Relevance
In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.

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Available from: Raul Zamora-Ros, May 20, 2014
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    • "heart disease , while having a diet relatively rich in saturated fats ) , amount up to 30 million US $ in the United States alone . However , a recently published and much talked about , large , long‐term epidemiological study showed that resveratrol in red wine , chocolate , and grapes was not associated with improved health in elderly Italians ( Semba et al . 2014 ) . Latif ( 2013 ) also mentions that most products used in studies contain more polyphenols than commercially available products . Furthermore , milk and white chocolate contain more sugar and ( far ) less beneficial compounds ."

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