Health is a complex and multifactorial construct that coincides with a state of complete physical, mental and social well-being and does not merely consist of the absence of disease, impairment, or infirmity. For this reason, pharmacological treatments alone cannot achieve well-being in the person to whom they are being administered. A growing body of studies on the placebo effect and unconventional treatments are testing the effectiveness of tools, techniques, and alternative procedures in pharmacological treatment, with more and more encouraging results. As a consequence of these findings, a new concept of care is emerging, which is pushing the specific techniques of each approach, pharmacological or not, into the background by focusing on the factors which are common to all treatments. The element that can summarize the majority of these factors is, in all likelihood, a helping relationship, within which techniques, medications, and placebos acquire meaning and significance as useful tools to achieve personal well-being.