Pediatric Infection and Intestinal Carriage Due to Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae

Antimicrobial Agents and Chemotherapy (Impact Factor: 4.48). 05/2014; 58(7). DOI: 10.1128/AAC.02558-14
Source: PubMed


The objective of this study is to describe the epidemiology of intestinal carriage with extended-spectrum-cephalosporin-resistant
Enterobacteriaceae in children with index infections with these organisms. Patients with resistant Escherichia coli or Klebsiella bacteria isolated from the urine or a normally sterile site between January 2006 and December 2010 were included in this
study. Available infection and stool isolates underwent phenotypic and molecular characterization. Clinical data relevant
to the infections were collected and analyzed. Overall, 105 patients were identified with 106 extended-spectrum-cephalosporin-resistant
E. coli (n = 92) or Klebsiella (n = 14) strains isolated from urine or a sterile site. Among the 27 patients who also had stool screening for resistant Enterobacteriaceae, 17 (63%) had intestinal carriage lasting a median of 199 days (range, 62 to 1,576). There were no significant differences
in demographic, clinical, and microbiological variables between those with and those without intestinal carriage. Eighteen
(17%) patients had 37 subsequent resistant Enterobacteriaceae infections identified: 31 urine and 6 blood. In a multivariable analysis, antibiotic intake in the 91 days prior to subsequent
urine culture was significantly associated with subsequent urinary tract infection with a resistant organism (hazard ratio,
14.3; 95% confidence interval [CI], 1.6 to 130.6). Intestinal carriage and reinfection were most commonly due to bacterial
strains of the same sequence type and with the same resistance determinants as the index extended-spectrum-cephalosporin-resistant
Enterobacteriaceae, but carriage and reinfection with different resistant Enterobacteriaceae strains also occurred.

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Available from: Xuan Qin, Oct 24, 2014
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