The paper traces the role of religion in contemporary criminology as well as reviewing the development of scholarly interest in religion within the field of criminology. We begin with a systematic review of 270 published studies in order to better understand the state of the literature examining the relationship between religion and crime. Our systematic review provides support for the notion that religious involvement is a relevant protective and prosocial factor. We then discuss how various dimensions of religiousness may explain crime and delinquency (directly and indirectly) and contribute to criminological theories and research. Additionally, we offer several potentially fruitful avenues for research examining the efficacy of the “faith factor” in both reducing crime and promoting prosocial behavior. We conclude with methodological and theoretical recommendations designed to assist scholars interested in research on the role of religion within criminology as well as prosocial studies more generally.