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Association of growth hormone (GH) and Prolactin (PRL) genes polymorphism with milk production trait in Polish Black-and-White cattle
Abstract and Figures
Associations were analysed between polymorphisms localized in intron 3 of the growth hormone gene (GH-MspI) and exon 3 of the prolactin gene (PRL-RsaI) and milk production traits of Black-and-White (Polish Friesian) cattle, including a total of 1086 cows. PCR-RFLP method was used for identification of genotypes. The following frequencies of genotypes and alleles were found: GH 0.766, 0.215 and 0.019 for +/+, +/-and-/-, respectively, and 0.873 and 0.127 for GH + and GH-, respectively; PRL 0.734, 0.257 and 0.009 for AA, AB and BB, respectively, and 0.862 and 0,138 for PRL A and PRL B , respectively. Significant differences between the herds were observed in the frequencies of both genotypes and alleles. In all three lactations the GH +/+ cows yielded most milk, whereas +/-cows showed higher milk fat content than +/+ individuals. AA cows of the PRL gene showed higher milk protein content than AB individuals. KEY WORDS: cattle / growth hormone / PCR-RFLP / polymorphism / prolactin / milk production Bovine growth hormone (bGH) is a single peptide of about 22-kDa molecular weight . It is composed of 190 or 191 amino acids, containing Ala or Phe at the N-terminus, due to alternative processing of bGH precursors [18, 24]. Moreover, Leu or Val amino acid substitutions at residue 127 exist due to the allelic polymorphism .
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