Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J et alA novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774

ArticleinNature 356(6372):768-774 · April 1992with18 Reads
Impact Factor: 41.46 · DOI: 10.1038/356768a0

    Abstract

    Interleukin-1β (IL-1β)-converting enzyme cleaves the
    IL-1β precursor to mature IL-1β, an important mediator of
    inflammation. The identification of the enzyme as a unique cysteine
    protease and the design of potent peptide aldehyde inhibitors are
    described. Purification and cloning of the complementary DNA indicates
    that IL-lβ-converting enzyme is composed of two nonidentical
    subunits that are derived from a single proenzyme, possibly by
    autoproteolysis. Selective inhibition of the enzyme in human blood
    monocytes blocks production of mature IL-1β, indicating that it is
    a potential therapeutic target.