Type 2 Diabetes Mellitus (T2DM) is a metabolic disease with an incidence and prevalence that is increas-ing worldwide, and associated with significant morbidity and mortality. It is estimated that the incidence and prevalence of T2DM will continue to increase globally, and unless urgent action is taken, this problem will continue to have direct consequences on the patient and the healthcare system. It has been shown that changes in lifestyle - regular exercise, healthy weight and eating habits - can prevent the development of T2DM mainly in high-risk patients, provided that physical activity is designed and performed in a similar fashion to that of successful cohort studies. Likewise, regular aerobic exercise and strength training in patients with prediabetes are critical in the management, control and prognosis of this condition, and have many benefits, not only for blood glucose control but also for cardiovascular, metabolic, anthropometric parameters, and even for cardiovascular-related mortality and all-causes mortality. For all these reasons, this review includes an overview of diabetes, the role of exercise in the prevention of T2DM, with its protective mechanisms, and it also provides some evidence-based recommendations for preventing T2DM with regular exercise. No financial conflicts of interest exist.