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A Quick Test of Cognitive Speed: Preliminary Screening Criteria for Arabic-Speaking Adults, Ages 40 to 80 Years

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A Quick Test of Cognitive Speed (AQT) color, form, and color-form scales were administered to 90 educated (5-22 years of education) and 45 uneducated (0-2 years of education) healthy, Arabic-speaking adults. Lognormal (In) transformations of time measures (sec.) were used for statistical analyses. There were statistically significant mean differences for the color-form processing-speed measures between middle-aged (ages 40-50) and older (ages 51-80) educated adults and between educated and uneducated adults (ages 40-78). The study developed preliminary criterion cut-off times for color-form naming for screening educated and uneducated Arabic-speaking adults. The normal, slower-than-normal, and atypical/pathological performance ranges were characterized with frequency distributions and standard deviations. Age and education are factors that must be considered in stratifying samples in future studies to develop valid and reliable criteria for cognitive screening of Arabic speakers with the AQT.
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ISSN 0031-5125DOI 10.2466/03.22.PMS.117x20z3
© Perceptual & Motor Skills 2013
Perceptual & Motor Skills: Physical Development & Measurement
A QUICK TEST OF COGNITIVE SPEED: PRELIMINARY SCREENING
CRITERIA FOR ARABIC-SPEAKING ADULTS, AGES 40 TO 80 YEARS
1 , 2
ELISABETH H. WIIG
Communication Disorders, Boston University
Knowledge Research Institute, Inc., Arlington, Texas
YOUSEF AL-HALEES
Communication Disorders, University of Jordan, Amman
Summary .— A Quick Test of Cognitive Speed (AQT) color, form, color-form, num-
ber and color-number naming scales were administered to 90 educated (5–22 years
of education) and 45 uneducated (0–2 years of education) healthy, Arabic-speaking
adults. Lognormal ( ln) transformations of time measures (sec.) were used for sta-
tistical analyses. There were statistically signi cant mean di erences for the color-
form processing-speed measures between middle-aged (ages 40–50) and older (ages
51–80) educated adults and between educated and uneducated adults (ages 40–78).
The study developed preliminary criterion cut-o times for color-form naming for
screening educated and uneducated Arabic-speaking adults. The normal, slower-
than-normal, and atypical/pathological performance ranges were characterized
with frequency distributions and standard deviations. Age and education are fac-
tors that must be considered in stratifying samples in future studies to develop
valid and reliable criteria for cognitive screening of Arabic speakers with the AQT.
The Arabic-speaking Middle Eastern population over age 65 has
been estimated to increase from 16.7 to 44.1 million between 1997 and
2025 ( Cummings, 2003 ). At the same time, the number of Arabic-speaking
immigrants to, for example, Western European and Scandinavian coun-
tries with universal health care has increased ( Nørskov, 2010 ). The Arab
population in Europe is estimated at 5 million
3 and the number of Arabic
speakers in the USA at 700,000. Cognitive aging in healthy adults has been
the focus of extensive studies, notably in Western societies ( Sachdev, 2003 ;
Fleischman, Wilson, Gabrieli, Bienias, & Bennett, 2004 ; Jacobson, Nielsen,
Minthon, Warkentin, & Wiig, 2004 ; Salthouse, 2004 ), but not in Arabic-
speaking, Middle Eastern societies. Few, if any, processing speed tests
2013, 117, 2, 1-12.
1 Address correspondence to Elisabeth H. Wiig, 2131 Re ection Bay Drive, Arlington, Texas
76013, USA or e-mail ( ehwiig@krii.com ).
2Professor Emeritus Yousef Al-Halees, Ph.D., Communication Disorders, Faculty of Arts and
Sciences, University of Jordan, Amman, Jordan collected the data for this study with insti-
tutional approval. The author, on behalf of Professor Al-Halees, expresses gratitude to the
University of Jordan and to the participants for supporting this preliminary investigation.
The study did not receive external funding.
3http://en.wikipedia.org/Arabs_in_Europe.
E. WIIG & Y. AL-HALEES
2
have been norm-referenced for Arabic-speaking adults. It is important to
provide culture-free, objective, behavioral measures in Arabic to di eren-
tiate normal cognitive aging from memory impairments caused by disease
processes. Because cognitive performance varies due to hereditary, devel-
opmental, educational, or environmental factors, it is necessary to develop
normative criteria for each culture and language for which a cognitive test
is intended ( Mejia, Gutierrez, Villa, & Ostrosky-Solis, 2003 ; Meija, Miguel,
Gutierrez, Villa, & Ostrosky-Solis, 2006 ; Nielsen & Wiig, 2006 ). The Quick
Test of Cognitive Speed (AQT) provides objective, timed measures of execu-
tive functioning and is proven to have broad cultural and linguistic appli-
cation ( Wiig, Nielsen, Minthon, & Warkentin, 2003 ; Nielsen & Wiig, 2006 ).
These factors prompted collection of normative data for healthy, educated,
Arabic-speaking adults and from uneducated adults for comparison.
The AQT uses a sustained rapid-naming format to assess process-
ing speed by measuring the time required to complete relatively simple
naming tasks with controlled input ( Wiig, Nielsen, Minthon, & Warken-
tin, 2002 , 2003 ). The subtests measure reaction, retrieval, and response
times, time to make choice decisions, and shifting cognitive set. The mea-
sures are sensitive to small changes in the time used for processing and
responding. Sustained naming causes speci c redistribution of cerebral
blood ow for the particular stimuli and tasks. During AQT color-form
combination naming, blood ow in healthy adults consistently increases
in the posterior temporal-parietal brain regions bilaterally and in subcor-
tical regions, including the hippocampus, while ow to frontal regions is
suppressed ( Wiig, et al., 2002 , 2003 ; Wiig, Nielsen, Minthon, McPeek, Said,
& Warkentin, 2002 ; Wiig, Nielsen, Minthon, & Jacobson, 2008 ). The acti-
vated regions are involved in the cognitive control of executive attention,
cognitive shifting, visual working memory, and automaticity of retrieval
( Baddeley, Bressi, Della Sala, Logie, & Spinnler, 1991 ; Downing, 2000 ;
Turken, Gabriel, Bammer, Baldo, Dronkers, & Gabrieli, 2008 ; Esterman,
Chui, Tamber-Rosenau, & Yantis, 2009 ; Berryhill, Chein, & Olson, 2011 ).
The AQT color, form, and color-form measures have been used to com-
pare e ects of Alzheimer's disease and dementia with Lewy bodies on
cognition and to identify individual responsiveness to speci c medica-
tion for Alzheimer's disease ( Andersson, Wiig, Londos, & Minthon, 2007 ;
Palmqvist, Minthon, Wattmo, Londos, & Hansson, 2010 ; Wiig, Annas,
Basun, Andreasen, Lannfelt, Zetterberg, et al., 2010 ; Palmqvist, 2011 ).
Among the AQT's statistical characteristics are (a) high rest-retest reli-
ability ( r = .84 to .96), (b) statistically non-signi cant di erences in per-
formances of men and women, (c) statistically non-signi cant e ects of
education after achieving literacy (Grades 8 and above), and (d) absence
of habituation and learning ( Wiig, Nielsen, Minthon, & Warkentin, 2002 ;
COGNITIVE SCREENING: ARABIC NORMS 3
Jacobson, et al., 2004 ; Nielsen & Wiig, 2006 ). There are statistically signi -
cant but small increases in AQT processing speed with age for color-form
combinations among American-English speaking adults; these are about 1
sec. per decade under age 60 and 1 sec. per seven years after age 60 ( Jacob-
son, et al., 2004 ). Criterion cut-o times (sec.) for processing speed do not
di er for English- and Scandinavian-speaking adults ( Wiig, Nielsen, Mint-
hon, & Warkentin, 2002 , 2003 ). In this study, the primary objective was to
obtain normative data for the AQT color-form processing speed tests for
cognitive screening of educated, Arabic-speaking adults. The second goal
was to compare processing speed measures among healthy, middle-aged
and older, educated and uneducated Arabic-speaking adults.
M ETHOD
Participants
There were 90 typically aging, educated adults (66 men; 24 women)
and 45 uneducated adults (14 men; 31 women). Participants were recruited
from contacts within the University of Jordan, the local mosque and its
community, and all of them volunteered. A health-wellness questionnaire,
designed by the researchers, with 10 questions, was administered for
inclusion. Of these, six questions asked for recent changes in habitual pat-
terns of eating, sleeping, work habits, social activities, and mood. Four
questions asked for the presence of untreated heart disease, past neurolog-
ical and psychiatric disorders, and familial dementia. Volunteers were not
excluded based on obesity or treated diabetes. Nine potential participants
were excluded based on past medical conditions (e.g., heart surgery) or
present changes in wellness patterns (e.g., mood and sleep patterns). The
participants gave informed consent in accordance with the Declaration of
Helsinki. All lived within the larger community of Amman, were natives
of Jordan and led functionally independent lives, holding low-level voca-
tional or professional jobs, depending on their educational level, and per-
formed societal responsibilities in their families and homes. Therefore, all
were presumed to function within the typical cognitive range for their age
and to be free of major interfering cognitive impairments.
The participants were rst grouped by level of education. This was
indicated by 2011 estimates that 66.7% of Jordanians aged 55 years and
above were illiterate and literacy rates were higher for men than for
women ( Anonymous, Jordan Times , 2012 ). Five years of formal education,
equivalent to having completed primary education (ages 6–11 years) ( Al-
No'aimi, 2008 ), formed the lower limit for the educated groups and two
years, corresponding to preschool, formed the upper limit for the unedu-
cated group. Within the educated group, 24% completed primary school,
49% secondary school, and 27% post-secondary education. Based on an
E. WIIG & Y. AL-HALEES
4
average life expectancy of about 74 years and of 71 years for males
4 , age
50 was chosen a priori to divide the participants into younger and older
groups. Group I (educated) with 45 adults (ages 40–50 years; M = 46.3 yr.,
SD = 3.6) had from 5–18 years of education ( M = 12.26, SD = 3.54). Group
II (educated) with 45 adults, ages 51–80 years ( M = 61.7 yr., SD = 6.3) had
from 5–22 years of education ( M = 10.3 yr., SD = 4.8). Group III (unedu-
cated) with 45 adults, ages 41–78 years ( M = 53.9, SD = 9.2) had between
zero and two years of formal education ( M = 0.6 yr., SD = 1.0). Group III
was further divided into (a) 22 adults, ranging in age from 41–50 years,
and (b) 23 adults, ranging in age from 50–78 years.
Measures
Of the AQT subtests, two require rapid naming of 40 single-dimen-
sion visual stimuli (colors or forms), measuring reaction, retrieval, and
response times. One requires rapid naming of 40 dual-dimension stim-
uli (color-form combinations), measuring reaction, response, and retrieval
times, and ‘switch cost,’ caused by co-articulating two stimulus labels.
The dual-dimension test also measures cognitive demands on executive
functions such as attention, working memory, and set-shifting.
Procedure
The AQT color, form, and color-form processing-speed tests were
administered in Arabic to all participants by Professor Yousef Al-Halees,
Ph.D., University of Jordan, Amman, Jordan. Familiarization trials estab-
lished adequacy and consistency in naming the stimuli. The order of
administration was xed with color naming, followed by form and color-
form naming. Total naming, time for each set of 40 stimuli was recorded
digitally in seconds and fractions of seconds, beginning with voice onset.
Analysis
Naming times (sec.) and lognormal ( ln ) transformations for each test
provided the basis for data analyses (IBM SPSS Statistics Version 21). The
analyses produced descriptive statistics and tested distributions for nor-
mality (Shapiro-Wilks W ). Multivariate analysis of variance (MANOVA)
tested the statistical signi cance of mean di erences between-groups.
Pearson correlations ( r ) explored relations between AQT naming mea-
sures ( ln ) and age and education. Frequency distributions, means, and
standard deviations for Groups I and II (educated adults) and IIIa and b
(uneducated adults) were used to establish preliminary processing speed
criteria (sec.) for the typical, slower-than-typical and atypical/pathologi-
cal performance ranges.
4www.indexmundi.com.
COGNITIVE SCREENING: ARABIC NORMS 5
R ESULTS
Descriptive statistics for color, form, and color-form naming times
(sec.) for Groups I and II (educated), and IIIa and b (uneducated) are
reported in Table 1 . Shapiro-Wilks W indicated that age in the total group
of educated ( n = 90) and uneducated adults ( n = 45) met normality criteria,
whereas naming time distributions (sec.) for the majority of the processing
speed measures did not. Therefore, all naming time measures were trans-
formed to lognormal ( ln ) measures for statistical comparisons of means
for Groups I, II, and IIIa and b. Adults in Groups I and II made a max-
imum of three naming errors for color-form combinations, and naming
errors were not further analyzed for criterion-referencing.
The correlations (Pearson r ) among age, education, and color-form
naming times ( Nielsen, Wiig, Warkentin, & Minthon, 2004 ; Warkentin,
Tsantali, Kiosseoglou, Minthon, Wiig, Nielsen, et al., 2005 ; Andersson, et
al., 2007 ; Palmqvist, 2011 ) were calculated in the educated adults ( n = 90).
In the total educated group, the correlations between age and color nam-
ing ( r = .54), form naming ( r = .52), and color-form naming ( r = .58) were
all statistically signi cant ( p s < .01), and e ect sizes were large. In Group I,
correlations between years of education and color naming ( r = –.37), form
naming ( r = –.53), and color-form naming ( r = –.35) met a priori criteria for
statistical signi cance ( p s > .01). In Group II, correlations between years of
education and color naming ( r = –.37), form naming ( r = –.50), and color-
form naming ( r = –.34) also were statistically signi cant ( p s < .01). E ect
sizes for education ranged from medium to large in both groups.
Multivariate analysis of variance (MANOVA) in an unbalanced design
compared means and evaluated the in uence of age and education on
color, form, and color-form naming times (after ln transformation). The
TABLE 1
D ESCRIPTIVE STATISTICS FOR A QUICK TEST OF COGNITIVE SPEED (AQT) BY AGE AND
EDUCATION GROUPS ( N = 135)
AQT
Group I
( n = 45)
Group II
( n = 45)
Group IIIa & b
( n = 45)
M SD M SD M SD
Color (sec.) 24.64 4.69 30.76 7.59 (a) 56.86
(b) 74.91
26.34
28.27
Form (sec.) 27.73 5.27 35.47 11.41
(a) 71.05
(b) 87.61
30.99
25.83
Color-form (sec.) 50.96 12.88 66.64 17.67
(a) 123.45
(b) 138.91
47.43
42.10
E. WIIG & Y. AL-HALEES
6
corrected model indicated statistically signi cant di erences for color
( F 3, 131 = 77.27), form ( F 3, 131 = 99.42), and color-form ( F 3, 131 = 84.54) ( ps < .01),
and the observed power was high for all (1.00). The results indicated no
signi cant interaction e ects ( ps > .05) for age × education for color ( F 1, 131 =
0.75), form ( F 1, 131 = 0.05), and color-form ( F 1, 131 = 1.73), and the observed
power was low for all measures. Di erences between age groups were sta-
tistically signi cant ( ps < .01) for color ( F 1, 131 = 19.28; η
2 = 0.96), form ( F 1, 131 =
17.85; η
2 = 0.95), and color-form ( F 1, 131 = 14.25; η
2 = 0.88), and the observed
power was high for all measures. Pairwise comparisons for the dependent
variable age indicated that naming times ( ln ) were consistently longer for
the older than for the middle-aged groups for all AQT measures ( ps < .01).
Di erences between levels of education also proved signi cant ( ps < .01)
for color ( F 1, 131 = 210.36, η
2 = ), form ( F 1, 131 = 277.08, η
2 = ), and color-form
( F 1, 131 = 231.00, η
2 = ), and the observed power was high for all measures.
Pairwise comparisons for level of education indicated that naming times
( ln ) were signi cantly longer for the uneducated than for the educated
groups for all AQT measures ( ps < .01).
Two methods were used to develop preliminary normative ranges for
typical, slower-than-typical, and atypical/pathological naming times for
color, form, and color-form naming and number and color-number nam-
ing subtest performances for Groups I, II, and III. The color-form mea-
sures have been used extensively in research and have proved sensitive in
identifying mild-to-moderate cognitive impairments ( Anderson, et al., 2007 ;
Palmqvist, et al., 2010 ; Wiig, et al., 2010 ; Palmqvist, 2011 ). The methods
used to specify performance time ranges in normative samples of Amer-
ican and Scandinavian speakers ( Wiig, Nielsen, Minthon, & Warkentin,
2002 , 2003 ) were duplicated. In the rst method, naming times (sec.) cor-
responding to +1 SD above the mean indicated the upper limits of typical
performance. Naming times corresponding to +2 SD above the mean indi-
cated the lower limits of atypical (potentially pathological) performance.
In the second method, naming times (sec.) corresponding to a cumula-
tive frequency of 84% indicated the upper limits of the typical perfor-
mance ranges. Naming times corresponding to a cumulative frequency
of 98.5% indicated the lower limits of atypical, potentially pathological
performance. The results of the two methods were compared to assess the
best t and approximate cut-o times (sec.) that would lend parsimony
and ease of reference for screening Arabic-speaking adults. The criterion
cut-o times for color-form naming along a performance continuum are
shown for the educated 40–50 and 51–80 year-olds (Groups I and II) and
for the 40–78 year-old uneducated adults (Group III) in Table 2 .
The cut-o naming times for the educated Arabic speakers proved
higher than previously observed for educated American-English speakers
AQ: 1 & 2
AQ: 3
COGNITIVE SCREENING: ARABIC NORMS 7
( Wiig, et al., 2002 ). To explore potential cross-linguistic di erences fur-
ther, 45 middle-aged American adults, ages 38–50 years ( M = 44.2, SD =
2.6), and 45 older adults, ages 51–80 years ( M = 62.6, SD = 3.9), were
selected from existing samples ( Wiig, et al., 2007 ; Nielsen & Wiig, 2011 )
and matched for sex and age within two years. Naming time means for
the 38- to 50-year-olds (Group I) were 21.78 sec. ( SD = 3.90) for color, 24.09
sec. ( SD = 3.44) for form, and 47.09 sec. ( SD = 7.43) for color-form. Nam-
ing time means for the 51- to 80-year-olds (Group II) were 23.31 sec. ( SD =
3.95) for color, 27.8 sec. ( SD = 5.83) for form, and 52.29 sec. ( SD = 8.94) for
color-form.
MANOVA with a balanced design tested for the signi cance of dif-
ferences resulting from language and age-level. The corrected model indi-
cated signi cant di erences for color ( F 3,176 = 20.44, η
2 = 1.00), form ( F 3,176 =
19.39, η
2 = 1.00), and color-form ( F 3,176 = 19.38, η
2 = 1.00) ( p s < .01). Lan-
guage × age interactions for color ( F 1,176 = 4.11, η
2 = 0.28), form ( F 1,176 = 1.48,
η
2 = 0.09), and color-form ( F 1,176 = 5.18, η
2 = 0.37) did not meet a priori cri-
teria for signi cance ( p s > .01). Di erences between languages proved sig-
ni cant ( p s < .01) for color ( F 1,176 = 39.93, η
2 =1.00), form ( F 1,176 = 28.23, η
2 =
0.99), and color-form ( F 1,176 = 16.93, η
2 = 0.93). Pairwise comparisons for
the dependent variable language indicated that naming times ( ln ) were
signi cantly longer for Arabic than for English speakers ( p < .01). Di er-
ences between age levels also proved signi cant ( ps < .01) for color ( F 1,176 =
17.27, η
2 = 0.94), form ( F 1,176 = 28.45, η
2 = 0.99) and color-form ( F 1,176 = 36.04,
η
2 = 1.00). Pairwise comparisons for the dependent variable age indicated
TABLE 2
C RITERION-REFERENCES CUT-OFF TIMES FOR A QUICK TEST OF COGNITIVE SPEED
SUBTESTS BY
AGE AND EDUCATION GROUPS ( N = 135)
Groups Normal Range Slower-than-Normal Atypical Range
I. Ages 40–50 yr.
Color < 30 sec. 31–34 sec. > 35 sec.
Form < 30 sec. 31–39 sec. > 40 sec.
Color-form < 65 sec. 66–74 sec. > 75 sec.
II. Ages 51–80 yr.
Color < 35 sec. 36–44 sec. > 45 sec.
Form < 45 sec. 46–54 sec. > 55 sec.
Color-form < 85 sec. 66–99 sec. > 100 sec.
III. Ages 41–78 yr.
Color < 95 sec. 96–125 sec. > 125 sec.
Form < 110 sec. 111–139 sec. > 140 sec.
Color-form < 175 sec. 176–219 sec. > 220 sec.
AQ: 4
AQ:5
E. WIIG & Y. AL-HALEES
8
that naming times ( ln ) for all AQT measures were consistently longer for
the older than for the middle-aged groups ( ps < 0.01). Cut-o times were
subsequently developed for the American adults based on these data. A
comparison of cut-o times for the educated Arabic and American adults
is presented in Table 3 .
D ISCUSSION
This study resulted in preliminary naming-time criteria for the AQT
color-form naming tests for culturally and linguistically representative
groups of educated and uneducated Arabic-speaking adults. The gender
bias in the educated and uneducated groups is considered to re ect cul-
turally dependent di erences in education and concurs with estimates for
literacy rates in Jordan ( Anonymous, Jordan Times , 2012 ). Among educated
Arabic-speaking adults, age was correlated with naming times for color,
form, and color-form naming ( r = .54, .52, and .58, respectively), and e ect
sizes were large. This concurs with prior ndings for American adults,
although correlations were lower ( r s = .37, .44, and .30, respectively) and
e ect sizes were medium ( Wiig, et al., 2007 ). Age contributed about one-
third of the variance in color-form naming among educated Arabic speak-
ers. This and life expectancy estimates supported the development of
separate criterion-referenced cut-o times for the educated speakers of
Arabic below and above 50 years of age.
MANOVA indicated no statistically signi cant interactions between
age and level of education for any of the AQT measures among Arabic
adults, and e ect sizes were low. Age a ected color, form, and color-
form naming speed between the middle-aged and older Arabic adults,
and e ect sizes were high. Level of education also a ected all naming
times, both within the educated groups and between the educated and
uneducated groups, and e ect sizes were high. In both the educated and
uneducated groups, middle-aged adults exhibited lower naming times
(greater speed) than older adults. This supported a priori hypotheses
that processing speed would be faster for all measures among middle-
TABLE 3
D IFFERENCES IN NORMAL RANGE CUT-OFF TIMES BETWEEN ARABIC GROUPS I/II ( N = 90) AND
AMERICAN GROUPS I/II ( N = 90)
Normal range cut-o E ect size of di erence
Arabic
(Group I)
Arabic
(Group II)
American
(Group I)
American
(Group II)
Arabic versus
American
Color < 30 sec < 35 sec < 25 sec < 30 sec η
2 = 1.00
Form < 30 sec < 45 sec < 30 sec < 35 sec η
2 = 0.99
Color-form < 65 sec < 85 sec < 55 sec < 60 sec η
2 = 0.93
COGNITIVE SCREENING: ARABIC NORMS 9
aged than among older educated and uneducated Arabic-speaking
adults. In turn, educated adults exhibited lower naming times (greater
speed) than uneducated adults for all measures. These di erences are
best explained by educational levels and indirectly by socio-economic
factors.
This is the rst normative study using the AQT color-form naming
subtest that has shown years of education to in uence naming times.
Among American English speakers, education has not been reported to
in uence processing speed in adults after Grade 8. In those studies, no
adults were included who were not in Grade 8 or who had completed less
than 8 years of formal education. However, a study of processing speed
by educated (literate) and uneducated (illiterate) West-African speakers
of Krio also reported signi cantly longer naming times for uneducated
adults, but color-form naming was not included and e ect sizes for the
statistical comparisons were not reported ( Nielsen & Wiig, 2006 ). In that
study, naming time means for color-number and color-animal name com-
binations were signi cantly ( ps < .01) longer for the 41 uneducated (73.10
and 82.98 sec., respectively) than for the 123 educated adults (55.30 and
76.13 sec., respectively). The reason that years of education resulted in
large group di erences in this study may in part be explained by the fact
that a relatively large proportion of the educated Arabic adults (24%) com-
pleted only 5–6 years of formal education (primary school). These adults
would be expected to have attained less verbal automaticity for naming
basic colors and forms as a result of education, and therefore would have
required more time to complete the naming tasks.
It is remarkable that the group means for the Arabic speakers con-
form to the AQT additive model for color-form naming ( Nielsen & Wiig,
2011 ). According to this model, the sum of the means for color and form
naming times approximates the mean for color-form naming. This nd-
ing suggested that cross-cultural di erences between American and Ara-
bic speakers may have resulted from linguistic factors such as syllable
length. An account of syllable length for the Arabic words indicates that
the color names /aħmr/, /azrq/, /asfr/, and /asu:d/, presented in the
International Phonetic Alphabet (IPA), contain two syllables each. The Ara-
bic form names /dæ:airæh/, /muθælæθ/, and /muræbæ/ contain three
syllables each and /xt/ (straight or not straight line) one syllable. In com-
parison, the English color words ‘red,’ ‘blue,’ and ‘black’ contain one syl-
lable each, and ‘yellow’ contains two syllables. The English form names
‘circle,’ ‘square,’ and ‘line’ contain one syllable each, and ‘triangle’ two syl-
lables. Thus, the possible Arabic color-form combinations would range
from a minimum of three syllables to a maximum of six syllables, while the
English equivalents would range from two to a maximum of four syllables.
E. WIIG & Y. AL-HALEES
10
To further explore the in uence of linguistic factors, subsequent com-
parisons of color, form and color-form naming times were performed for
age- and sex-matched, educated Arabic and American English speakers.
MANOVA indicated no signi cant interactions ( p > .01) between age and
language for color, form, or color-form naming, and e ect sizes were
small. Age-level di erences were signi cant for both Arabic and American
speakers, and e ect sizes were large. As expected, naming times were sig-
ni cantly longer for the older for than the middle-aged Arabic and Ameri-
can adults. Di erences between speakers of Arabic and American adults
also were signi cant, and e ect sizes were large. Naming times proved
signi cantly longer for Arabic than for American adults, and e ect sizes
were large. These di erences resulted in the cut-o time criteria (sec.)
for color-form naming for educated Arabic adults that were 5 sec. longer
for color and 25 sec. longer for color-form naming than for the American
adults in the present sample.
The number of naming errors was low among the educated speakers
of Arabic, with a maximum of two errors for single-dimension and three
errors for dual-dimension naming. This nding agrees with observations
for healthy American and Scandinavian adults ( Wiig, Nielsen, Minthon, &
Warkentin, 2002 , 2003 ). A larger-than-expected number of naming errors,
more than two or three, would indicate self-monitoring problems. Clearly,
cross-cultural criterion referencing for the AQT color-form naming time
measures must account for di erences in age as well as in years of education.
One of the limitations of this study is that the two age groups (Groups
I and II) contained only 45 adults each, when samples of 50–100 would
have been desirable. Moreover, the limited sample size ( n s = 22 and 23)
for the two age groups of uneducated adults places severe restrictions on
both interpretation and application of the ndings for these groups. A sec-
ond limitation relates to the lack of strati cation by age in the older edu-
cated group of Arabic speakers, a limitation that results from the restricted
sample size. Studies with larger samples of participants with better strat-
i cation based on both age and years of education should provide more
reliable and valid performance criteria. A third important limitation is that
the study did not assess the clinical utility of the preliminary norm-refer-
enced criteria for AQT single- and dual-dimension processing speed for
cognitive screening of Arabic-speaking adults.
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Accepted September 17 , 2013 .
AQ:6
AUTHOR QUERIES
AQ1: Please add e ect size.
AQ2: Please add e ect size.
AQ3: Please add e ect size.
AQ4: Eta square is e ect size, not power; please check the numbers.
AQ5: Which Wiig et al., 2002 reference is this? There are two.
AQ6: What was the date of this conference?
... There are virtually no AQT practice effects, test-retest reliability is high (Humes et al., 2013) and cultural bias reportedly low (Dsurney, 2007;Takahashi et al., 2012;Wiig et al., 2002a) although differences in syllable length across languages, and thereby naming speeds, motivate language-specific norms (Wiig & Al-Halees, 2013). Literacy is not required even if it facilitates performance (Nielsen & Wiig, 2006) and correlations with educational levels beyond 8 years of schooling are typically low, but not in all samples (Nielsen & Wiig, 2006;Petrazzuoli et al., 2014;Takahashi et al., 2012;Wiig & Al-Halees, 2013). ...
... There are virtually no AQT practice effects, test-retest reliability is high (Humes et al., 2013) and cultural bias reportedly low (Dsurney, 2007;Takahashi et al., 2012;Wiig et al., 2002a) although differences in syllable length across languages, and thereby naming speeds, motivate language-specific norms (Wiig & Al-Halees, 2013). Literacy is not required even if it facilitates performance (Nielsen & Wiig, 2006) and correlations with educational levels beyond 8 years of schooling are typically low, but not in all samples (Nielsen & Wiig, 2006;Petrazzuoli et al., 2014;Takahashi et al., 2012;Wiig & Al-Halees, 2013). ...
... Easy-to-use regression-based norms, stratified by age and gender, are provided in Table 4 and the results are discussed in detail below. The nonlinear effect of years of education on AQT1 performance only (although AQT3 performance also correlated with years of education) is in line with previous findings that AQT is relatively independent of education once a certain level of attainment, around 8-10 years of schooling, has been reached (Nielsen & Wiig, 2006;Petrazzuoli et al., 2014;Wiig & Al-Halees, 2013). Processing speed tends to be less influenced by education than other cognitive domains, supporting a closer relation to neurobiological function than to acquired skills (Lu et al., 2013;Tucker-Drob et al., 2009). ...
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Slowed processing speed is part of normal aging but also a symptom of many diseases, including dementia. A Quick Test of Cognitive Speed (AQT) consists of three conditions: color naming (AQT1), form naming (AQT2) and dual color-form naming (AQT3) and offers a user-friendly assessment of processing speed that is used internationally to identify cognitive impairment in elderly patients. Appropriate age-norms have however been lacking. This study provides regression-based norms derived from a Swedish sample of 158 cognitively healthy 80 to 94-year olds. The results show age effects in all three conditions, a non-linear education effect in AQT1, and age by gender interactions in AQT2 and AQT3: men performed worse with increasing age, but women remained on a par. However, irrespective of age and gender, AQT2 and AQT3 mean raw and predicted scores were slower than the hitherto recommended cutoff criteria for suspected cognitive impairment.
... The Mini-Mental State Examination (MMSE) and the Clock Drawing Test (CDT) are diagnostic tests for dementia, whose accuracy is still questionable, and which limits the ability to diagnose patients with early-stage dementia and MCI [10]. In contrast, the use of visual-verbal scales such as A Quick Test of Cognitive Speed (AQT) that are not in uenced by factors such as gender, formal education beyond the acquisition of literacy (Grades 5 to 8), and culture, can distinguish between normal aging and cognitive disorders caused by disease [11]. ...
... A Quick Test of Cognitive Speed (AQT) was later designed by Wiig et al. to compare processing speed in adults with clinical diagnoses of dementia and neurotypical age peers [14][15][16][17]. AQT is a visual-verbal processing speed test that evaluates aspects of executive function and can be used in a variety of languages and cultures [7,11, 18]. AQT measures the speed of perception, retrieval, and naming of basic colors and forms in singledimension naming and cognitive speed associated with central executive functions (attention, working memory, and set shifting) in dual-dimension naming of color-form combinations. ...
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Background: Cognitive disorders are one of the most important issues in old age. They may remain hidden in the early stages. There are many cognitive tests, but some variables affect their results (e.g., age and education.) This study aimed to evaluate the reliability and validity of A Quick Test of Cognitive Speed (AQT) in Iranian older adults. Methods: This study aimed to test the psychometric properties of AQT. 114 older adults participated in the study and were divided into three groups (46 with mild cognitive impairments (MCI), 24 with dementia, and 45 without MCI and dementia) based on the diagnosis of two geriatric psychiatrists. Participants were assessed by AQT and Mini-Mental State Examination (MMSE). Data were analyzed using Pearson correlation, independent t-test, and ROC curve by SPSS v.23. Results: There was no significant correlation between AQT subscales and age and no significant difference between the AQT subscales in male and female, educational levels, and marital status. The test-retest correlations (r) were significant for Color (C) 0.84, Form (F) 0.91 and Color-Form (CF) 0.94. Convergent validity was significant between MMSE and AQT. Its correlation was with Color -0.78, Form -0.71, and Color-Form -0.72. The cut-off point for Color was 43.50 s, Form 52 s, and Color-Form 89 s were based on sensitivity and specificity for differentiating older patients with MCI with controls. The cut-off point for Color was 62.50 s, for Form 111 s, and Color-Form 197.50 s based on sensitivity and specificity measures for differentiating older patients with dementia and MCI. Conclusion: The findings of this study showed that A Quick Test of Cognitive Speed (AQT) is a suitable tool for assessing cognitive function in older adults.
... In contrast, the use of visual-verbal scales such as A Quick Test of Cognitive Speed (AQT) that are not influenced by factors such as gender, formal education beyond the acquisition of literacy (Grades 5 to 8), and culture, can distinguish between normal aging and cognitive disorders caused by disease [16]. ...
... A Quick Test of Cognitive Speed (AQT) was later designed by Wiig et al. to compare processing speed in adults with clinical diagnoses of dementia and neurotypical age peers [18][19][20][21]. AQT is a visual-verbal processing speed test that evaluates aspects of executive function and can be used in a variety of languages and cultures [5,16,22]. AQT measures the speed of perception, retrieval, and naming of basic colors and forms in single-dimension naming and cognitive speed associated with central executive functions (attention, working memory, and set shifting) in dual-dimension naming of color-form combinations. The study showed that a decline in the speed of perception and cognition precedes a decline in linguistic-cognitive abilities in mild to moderate severity of AD [10]. ...
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Background Cognitive disorders are one of the important issues in old age. There are many cognitive tests, but some variables affect their results (e.g., age and education). This study aimed to evaluate the reliability and validity of A Quick Test of Cognitive Speed (AQT) in screening for mild cognitive impairment (MCI) and dementia. Methods This is a psychometric properties study. 115 older adults participated in the study and were divided into three groups (46 with MCI, 24 with dementia, and 45 control) based on the diagnosis of two geriatric psychiatrists. Participants were assessed by AQT and Mini-Mental State Examination (MMSE). Data were analyzed using Pearson correlation, independent t-test, and ROC curve by SPSS v.23. Results There was no significant correlation between AQT subscales and age and no significant difference between the AQT subscales in sex, educational levels. The test-retest correlations ranges were 0.84 from 097. Concurrent validity was significant between MMSE and AQT. Its correlation was with Color − 0.78, Form − 0.71, and Color-Form − 0.72. The cut-off point for Color was 43.50 s, Form 52 s, and Color-Form 89 s were based on sensitivity and specificity for differentiating older patients with MCI with controls. The cut-off point for Color was 62.50 s, for Form 111 s, and Color-Form 197.50 s based on sensitivity and specificity measures for differentiating older patients with dementia and MCI. Conclusion The findings showed that AQT is a suitable tool for screening cognitive function in older adults.
... Years of education also correlated significantly but weakly with AQT naming times, a finding previously unreported. The differences between AQT naming times in 46 Italian primary care patients aged 56-70 years in this study and 90 American subjects (Nielsen and Wiig, 2011) of the same age range seen in Table 3 were considerably smaller than the differences between 90 American subjects and 90 healthy Arabic speaking Jordanian adults of the same age range (Wiig and Al-Halees, 2013). This may reflect cultural, educational, and linguistic differences. ...
... And for the AQT brain processing speed test there are few published studies on the performance of cognitively healthy people. To our knowledge, only two previous normative AQT studies have used a larger population than the present study (Bruna et al., 2007;Wiig and Al-Halees, 2013). We have designed a future validation study to establish AQT sensitivity and specificity measures in the Italian population to differentiate between neurotypical adults and adults with mild cognitive impairment or mild-to-moderate dementia. ...
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Background A Quick Test of Cognitive Speed (AQT) is a brief test that can identify cognitive impairment. AQT has been validated in Arabic, English, Greek, Japanese, Norwegian, Spanish, and Swedish. The aim of this study was to develop Italian criterion-referenced norms for AQT. Methods AQT consists of three test plates where the patient shall rapidly name (1) the color of 40 blue, red, yellow, or black squares (AQT color), (2) the form of 40 black figures (circles, squares, triangles, or rectangles; AQT form), (3) the color and form of 40 figures (consisting of previous colors and forms; AQT color–form). The AQT test was administered to 121 Italian cognitively healthy primary care patients (age range: 45–90 years). Their mean Mini-Mental State Examination (MMSE) score was 28.8 ± 0.9 points (range 26–30 points). AQT naming times in seconds were used for developing preliminary criterion cut-off times for different age groups. Results Age was found to have a significant moderate positive correlation with AQT naming times color (r = 0.65, p < 0.001), form (r = 0.53, p < 0.001), color–form (r = 0.63, p < 0.001) and a moderate negative correlation with MMSE score (r = –0.44, p < 0.001) and AQT naming times differed significantly between younger (45–55 years old), older (56–70 years old), and the oldest (71–90 years old) participants. Years of education correlated positively but weakly with MMSE score (r = 0.27, p = 0.003) and negatively but weakly with AQT color (r = –0.16, p = ns), form (r = –0.24, p = 0.007), and color–form (r = –0.19, p = 0.005). We established preliminary cut-off times for the AQT test based on +1 and +2 standard deviations according to the approach in other languages and settings. Conclusions This is the first Italian normative AQT study. Future studies of AQT – a test useful for dementia screening in primary care – will eventually refine cut-off times for normality balancing sensitivity and specificity in cognitive diagnostics.
... Even if normative data on an Arabic-speaking population are available, mismatch between the normative and test samples remains a likely problem due to differences in Arabic dialects, educational systems, and achievement expectations at a given grade level across Arab countries (Mahmood, 2015). Indeed, much of the published Arabic normative data relevant to AD assessment were collected in only a handful of individual countries, including Saudi Arabia (Khalil, 2010;Al-Ghatani, Obonsawin, Binshaig, & Al-Moutaery, 2011), Oman (Poreh, Sultan, & Levin, 2012), Jordan (Wiig & Al-Halees, 2013), and Tunisia (Ben Jemaa et al., 2017). Notably, most Arab American older adults did not emigrate from these countries, but rather from Lebanon, Egypt, Syria, or Iraq (U.S. Census, 2014). ...
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Background and Objectives This article highlights the dearth of and need for research on Arab American cognitive aging. We propose that studying cognitive health issues among older Arab Americans provides an innovative opportunity to advance knowledge about causes and consequences of Alzheimer’s disease (AD) disparities and refine understanding of factors linked to immigrant health in the United States. Research Design and Methods Demographic information is provided on Arab Americans, who are on the cusp of being recognized by the U.S. government as a distinct ethnic group separate from whites. In the tradition of minority aging, we present a broad review of specific issues in the contemporary case of Arab Americans. Results We detail how including Arab Americans provides unique information on the importance of: (i) extending racial/ethnic group comparisons; (ii) linking social experiences to late-life cognitive health; and (iii) incorporating ethnic factors related to immigration and religion in the study of AD disparities. Discussion and Implications Studying Arab American cognitive aging provides an innovative opportunity to more fully delineate factors that create and sustain health disparities, with special insights into both causes and consequences.
... SCT: In a similar test version, Andersson et al (2001) found that mean SCT performance was 71%, but that level of performance applied to a sample with more profound hearing impairment. The current high performance level (0.83) is still within one SD of the Andersson (Wiig & Al-Halees, 2013). The difference score between RANCS and the sum of RANC + RANS is also positive and similar in magnitude to previous research (Warkentin et al, 2005;Wiig et al, 2010). ...
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Objective: The aims of the current n200 study were to assess the structural relations between three classes of test variables (i.e. HEARING, COGNITION and aided speech-in-noise OUTCOMES) and to describe the theoretical implications of these relations for the Ease of Language Understanding (ELU) model. Study sample: Participants were 200 hard-of-hearing hearing-aid users, with a mean age of 60.8 years. Forty-three percent were females and the mean hearing threshold in the better ear was 37.4 dB HL. Design: LEVEL1 factor analyses extracted one factor per test and/or cognitive function based on a priori conceptualizations. The more abstract LEVEL 2 factor analyses were performed separately for the three classes of test variables. Results: The HEARING test variables resulted in two LEVEL 2 factors, which we labelled SENSITIVITY and TEMPORAL FINE STRUCTURE; the COGNITIVE variables in one COGNITION factor only, and OUTCOMES in two factors, NO CONTEXT and CONTEXT. COGNITION predicted the NO CONTEXT factor to a stronger extent than the CONTEXT outcome factor. TEMPORAL FINE STRUCTURE and SENSITIVITY were associated with COGNITION and all three contributed significantly and independently to especially the NO CONTEXT outcome scores (R(2) = 0.40). Conclusions: All LEVEL 2 factors are important theoretically as well as for clinical assessment.
... Data presented show that a larger proportion in each age group had completed less than eight years of formal education. Previous studies indicate that years of education is not a signifi cant factor after Grade 8 or attainment of basic literacy, but is a nifi cant factor among lesser educated adults ( Nielsen & Wiig, 2006 ; Wiig & Al-Halees, 2013). Cognitive normality was checked via the Mini-Mental State Examination (MMSE: Folstein, Folstein, & McHugh, 1975 ). ...
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-A Quick Test of Cognitive Speed was administered to 357 participants without cognitive impairment, aged 18 to 85 years, to explore the effects of age on processing speed variables in Spanish speakers and to provide normative data for the test adapted to this population. Results were consistent with previous findings: correlations between age and naming times were high and statistically significant. Linear regression indicated that cognitive processing speed on this test slows 2 to 4 sec. per decade, depending on the task. Normalized data were provided. The findings concur with several studies that have linked age-cognitive impairment with slowing processing speed. This study attempted to assess the importance of this relation, as information processing speed could be considered a measure of cognitive impairment in everyday clinical screening evaluations.
... The third requires rapid naming of 40 dualdimension color-form combinations (e.g., red circle) and measures cognitive speed (i.e., perceptual speed + overhead from switch costs and demands on executive functions). Norm-referenced criteria for adults have been established in several countries so that the AQT can be used as a screening tool for dementia (e.g., Jacobson et al. 2004 ;Palmqvist et al. 2010 ;Petrazzuoli et al. 2014 ;Wiig and Al-Halees 2013 ). The reliability of AQT color, form, and color-form naming is also robust with testretest reliability coefficients ranging from 0.91 to 0.95, and there is no evidence of habituation or learning (Wiig et al. 2002a , b ). ...
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Forty neurotypical adults (ages 65-74) were administered three different assessments, as follows: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive Speed (AQT), and Stroop Color and Word Test. Correlation coefficients (Pearson r) indicated a significant but moderate association between MoCA scores and AQT dual-dimension processing speed (p < 0.01). AQT color and color-form combination naming correlated significantly with Stroop Color, Word, and Color-Word t-scores, and the observed statistical power was high. Form naming correlated significantly with Stroop Word and Color-Word measures (p < 0.01). The associations between the AQT color, form, and color-form combination and Stroop interference measures were low and non-significant (p > 0.01). Based on evidence of frontal lobe control of inhibition (Stroop) and bilateral temporal-parietal control of dual-dimension processing speed (AQT), results suggest that the AQT dual-dimension processing-speed and Stroop interference tests may complement each other in differentiating dementias associated with frontal and posterior lesions.
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Guía clínica para el cribado y seguimiento del deterioro cognitivo mediante la evaluación de la velocidad de procesamiento de la información. Edición en español.
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There is a great need for quick tests that identify treatment response in Alzheimer's disease (AD) to determine who benefits from the treatment. In this study, A Quick Test of cognitive speed (AQT) was compared with the mini-mental state examination (MMSE) in the evaluation of treatment outcome in AD. 75 patients with mild to moderate AD at a memory clinic were assessed with AQT and the MMSE at a pretreatment visit, at baseline and after 8 weeks of treatment with cholinesterase inhibitors (ChEI) initiated at baseline. Changes in the mean test scores before and after treatment were compared, as well as the number of treatment responders detected by each test, according to a reliable change index (RCI). After 8 weeks of treatment, the AQT improvement, expressed as a percentage, was significantly greater than that of the MMSE (P = 0.026). According to the RCI, the cut-offs to define a responder were ≥16 seconds improvement on AQT and ≥3 points on the MMSE after 8 weeks. With these cut-offs, both tests falsely classified ≤5% as responders during the pretreatment period. After 8 weeks of treatment, AQT detected significantly more responders than the MMSE (34% compared with 17%; P = 0.024). After 6 months of treatment, the 8-week AQT responders still showed a significantly better treatment response than the AQT nonresponders (22.3 seconds in mean difference; P < 0.001). AQT detects twice as many treatment responders as the MMSE. It seems that AQT can, already after 8 weeks, identify the AD patients who will continue to benefit from ChEI treatment.
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Efficient execution of perceptual-motor tasks requires rapid voluntary reconfiguration of cognitive task sets as circumstances unfold. Such acts of cognitive control, which are thought to rely on a network of cortical regions in prefrontal and posterior parietal cortex, include voluntary shifts of attention among perceptual inputs or among memory representations, or switches between categorization or stimulus-response mapping rules. A critical unanswered question is whether task set shifts in these different domains are controlled by a common, domain-independent mechanism or by separate, domain-specific mechanisms. Recent studies have implicated a common region of medial superior parietal lobule (mSPL) as a domain-independent source of cognitive control during shifts between perceptual, mnemonic, and rule representations. Here, we use fMRI and event-related multivoxel pattern classification to show that spatial patterns of brain activity within mSPL reliably express which of several domains of cognitive control is at play on a moment-by-moment basis. Critically, these spatiotemporal brain patterns are stable over time within subjects tested several months apart and across a variety of tasks, including shifting visuospatial attention, switching categorization rules, and shifting attention in working memory.
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A previous study (Baddeley et al., 1986) explored the hypothesis that patients suffering from dementia of the Alzheimer type (AD) are particularly impaired in the functioning of the central executive component of working memory. It showed that, when patients are required to perform 2 concurrent tasks simultaneously, the AD patients are particularly impaired, even when level of performance on the individual tasks is equated with that of age-matched controls. Although the results were clear, interpretation was still complicated by 2 issues: first, the question of comparability of performance on the separate tests between AD and control patients: secondly, the question of whether our results could be interpreted simply in terms of a limited general processing capacity being more taxed by more difficult dual tasks than by the individual tasks performed alone. The present study followed up the AD and control patients after 6 and 12 mths. We were able to allow for the problem of comparability of performance by using patients as their own control. Under these conditions, there is a very clear tendency for dual task performance to deteriorate while single task performance is maintained. A second experiment varied difficulty within a single task in which patients and controls were required to categorize words as belonging to 1, 2 or 4 semantic categories. There was a clear effect of number of categories on performance and a systematic decline in performance over time. There was, however, no interaction between task difficulty as measured by number of alternatives and rate of deterioration, suggesting that the progressive deterioration in performance shown by AD patients is a function of whether single or dual task performance is required, and is not dependent on simple level of task difficulty. Implications for the analysis of the central executive component of working memory are discus
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Adult age differences have been documented on a wide variety of cognitive variables, but the reasons for these differences are still poorly understood. In this article, I describe several findings that will need to be incorporated into eventual explanations of the phenomenon of cognitive aging. Despite common assumptions to the contrary, age-related declines in measures of cognitive functioning (a) are relatively large, (b) begin in early adulthood, (c) are evident in several different types of cognitive abilities, and (d) are not always accompanied by increases in between-person variability. The phenomenon of cognitive aging has been noticed almost as long as the phenomenon of physical aging, but it is still not well understood. This is unfortunate because cognitive functioning can affect one's quality of life, and even the ability to live independently. Furthermore, cognitive functioning in early adulthood may be related to the devel-opment of pathologies such as Alzheimer's disease in later adulthood. One way to conceptualize understanding is that it is equivalent to knowing answers to the questions of what, when, why, where, and how. In this article, I summarize some of the progress that has been achieved in describing the phenomenon of cognitive aging in terms of the questions of what and when. Although not much is yet known about why (what is ultimately responsible), where (in the nervous system), and how (via what mechanisms) age-related cognitive changes occur, a key assumption of my research is that answering these other questions will be easier as the characterization of what and when becomes more precise.
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Color-form naming in A Quick Test of Cognitive Speed (AQT) is used to assess processing speed on three rapid automatic naming tasks, two of which measure single-dimension and the third of which measures dual-dimension naming speed. These tests have been used to identify changes in processing speed associated with normal aging. The present study evaluated whether a simple additive model could explain the normally expected relation between scores on measures of single- and dual-dimension naming speed. The AQT color (C), form (F), and color-form (CF) naming tests were administered individually to 270 adults (ages 18 to 70 yr.). Paired-sample t tests mean comparisons of C+F and CF naming times for the total group and for three age cohorts (ages 18 to 34, 35 to 54, and 55 to 70), each with 90 adults, indicated significant mean differences between these processing-speed measures for the total group and for the 18- to 34- and 35- to 54-year age cohorts. Thus, a simple additive model does not explain the relationship between single- and dual-dimension naming speed across ages. To provide a better description, an additive model with "overhead" (a measure of processing efficiency) was proposed and norm-referenced for using the AQT tests to assess normal and atypical ranges for dual-dimension processing efficiency (overhead). ANOVA with post hoc analysis (Scheffé) compared AQT C + F, CF, and overhead means across age cohorts. The results indicated significant mean differences for the CF and overhead measures, but not for the C+F measure. Normative ranges for typical overhead sizes were established for each age cohort. In clinical practice, an overhead larger than typical or normal for a given age would suggest executive dysfunction, involving attention, visual working memory, and set shifting.
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To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.