The aim of this manual is to offer a guide and training tool for social workers and other helping professions dealing with clients in the dynamic European social, economic, political, cultural, and religious frame in the beginning of the 21st century. After discussions on methods, explained in this book (I.3.), we organized the twenty chapters around four main aspects: a first part with founding elements (I.1. — I.5.), a second part with insights (II.1. — II.3.), a third part with reflections on spirituality and ethics regarding different social levels (III.1. — III.6.), and a fourth part with selected fields of application (IV.1. — IV.6.). With the first chapter (Opatrný, I.1.), readers are placed in the context of the European situation in the new millennium with a growing religious plurality and cultural diversity. These are the result of secularization waves, the adaptations and transformations of Christendom, migration processes, economic changes, and new geopolitical constellations. The second chapter (Gehrig, I.2.) puts in the centre the core reality and reason for existence of the social work profession: the human being. To help other people professionally requires an understanding of the person, the environment, the complexity of life and a reflexive attitude and capacity to comprehend these situations, processes, and persons. The chapter opens the discussion from a Christian humanist perspective with a focus on the concept of person. The third chapter on interdisciplinarity and method (Baumann, I.3.) is like a hinge between the initial contextualization, the following insights and the rest of the book. Its more complex and theoretical orientation based on Lonergan’s model of four levels of conscious intentionality offers a holistic tool for reflection on practice by which social workers can enhance their ability to be more attentive, intelligent, reasonable, and responsible. In continuity with the chapter and its interdisciplinary orientations, Gehrig shows in I.4. how spirituality is a field for encounters between theology and social work. Insights concludes with a theoretical comparative reading on the connection of social work to related concepts of law, ethics, and religion as expressions of norms (Birher, I.5.). Social workers are aware of how normative frames influence the professional practice and situations, clients find themselves in our societies. The second part of the book with its three chapters centres the attention on the core concepts of the topic, the founding elements. This part starts with a short explanation of the fundamental ethical and practical question of commitment to 328 clients in social work in the context of spirituality and ethics (Opatrný, II.1.). The issue of commitment appears as a continuous element in the book and its chapters. For understanding of the concept of spirituality in this manual and for social work, chapter II.2. (Opatrný and Gehrig) delivers the necessary understandings, followed by some basic ideas on social ethics addressed to the profession (Lacca, II.3.). In the third, more extensive part of the book, readers find explanations of spirituality and ethics on different social levels in practical fields, especially the context of organizations. Baumann offers a bridging chapter between parts two and three (III.1.), where the spirituality of the clients, of social workers, and the ethos of the organizations in a secular age are connected towards a spiritually and ethically attentive, intelligent, reasonable and responsible practice. In III.2., Opatrný reflects on the practice of spiritual assessment as a tool and expression of spiritual sensitive practice in the helping professions. Readers can find here some models and practical orientations. The following chapter III.3. (Lacca), enlarges the questions related to assessment by an ethical reflection on the topic. The rest of the third part is dedicated to the organizational field and leadership. Readers will find an example with the case of ecclesial charitable organizations (III.4., Birher), where the author connects with the ideas expressed in I.5. on norms and explains them; in III.5, Blank and Šimr show the cases of a Protestant and a Catholic organization in Germany and the Czech Republic and its support for the topic of spirituality; III.6. (Baumann) finishes part three with reflections on leadership in social work related to spirituality. The fourth part with selected fields of application shows how the topic of spirituality and ethics appears in exemplified groups and fields of reference for social work. IV.1. (Muñoz and Pereñiguez) describes for social workers the dramatic situations of refugees and migrants and the emerging spiritual questions related to it. Both authors then present in IV.2. a dialogue on how spirituality can be a part of female empowerment and an instrument for social change. In chapter IV.3. (Moya Faz and Baumann) we have included the topic of mental health, as spirituality frequently appears in psychological and health care research. Social workers have a strong professional presence in this field, too; actually, mental health is a topic in most of the training programs for social work. Youth work and spirituality in Ireland (IV.4., McManus) expresses an emerging topic and is the result of the enriching encounters and trainings of academics and practitioners in the project. Of course, the 329 challenging European social reality of elderly people is a necessary and urging focus in the topic of social work and spirituality and an ethical practice. Suchomelová and Moya Faz summarize the important aspects in chapter IV.5. The applications part finishes with a short reflection on the community development (Opatrný), as social work is not only case work or organizational practice, and people always belong to communities, groups of reference and relational local social realities which have to be integrated in the spiritually sensitive social work.