Context
The free and open sharing of information, data, and materials regarding
published research is vital to the replication of published results, the efficient
advancement of science, and the education of students. Yet in daily practice,
the ideal of free sharing is often breached.Objective
To understand the nature, extent, and consequences of data withholding
in academic genetics.Design, Setting, and Participants
Mailed survey (March-July 2000) of geneticists and other life scientists
in the 100 US universities that received the most funding from the National
Institutes of Health in 1998. Of a potential 3000 respondents, 2893 were eligible
and 1849 responded, yielding an overall response rate of 64%. We analyzed
a subsample of 1240 self-identified geneticists and made a limited number
of comparisons with 600 self-identified nongeneticists.Main Outcome Measures
Percentage of faculty who made requests for data that were denied; percentage
of respondents who denied requests; influences on and consequences of withholding
data; and changes over time in perceived willingness to share data.Results
Forty-seven percent of geneticists who asked other faculty for additional
information, data, or materials regarding published research reported that
at least 1 of their requests had been denied in the preceding 3 years. Ten
percent of all postpublication requests for additional information were denied.
Because they were denied access to data, 28% of geneticists reported that
they had been unable to confirm published research. Twelve percent said that
in the previous 3 years, they had denied another academician's request for
data concerning published results. Among geneticists who said they had intentionally
withheld data regarding their published work, 80% reported that it required
too much effort to produce the materials or information; 64%, that they were
protecting the ability of a graduate student, postdoctoral fellow, or junior
faculty member to publish; and 53%, that they were protecting their own ability
to publish. Thirty-five percent of geneticists said that sharing had decreased
during the last decade; 14%, that sharing had increased. Geneticists were
as likely as other life scientists to deny others' requests (odds ratio [OR],
1.39; 95% confidence interval [CI], 0.81-2.40) and to have their own requests
denied (OR, 0.97; 95% CI, 0.69-1.40). However, other life scientists were
less likely to report that withholding had a negative impact on their own
research as well as their field of research.Conclusions
Data withholding occurs in academic genetics and it affects essential
scientific activities such as the ability to confirm published results. Lack
of resources and issues of scientific priority may play an important role
in scientists' decisions to withhold data, materials, and information from
other academic geneticists.
Figures in this Article
Without the free exchange of published scientific information and resources,
researchers may unknowingly build on something less than the total accumulation
of scientific knowledge or work on problems already solved.1
However, a number of instances of data withholding (defining data to include
the full range of research results, techniques, and materials useful in future
investigations and withholding as the failure to share such published data)
have been reported.2- 7
A 1994-1995 survey of academic life scientists found that 34% of respondents
were denied research results requested from a fellow university scientist
in the previous 3 years, and 8.9% said they had denied a request from another
university scientist for access to research results.8
Weinberg9 asserts that secrecy is more
common in genetics and particularly human genetics than in other areas. Reasons
may include the increased scientific competitiveness of the field and the
opportunities for commercial applications.10
Research has shown that scientists who reported conducting research on goals
similar to that of the Human Genome Project (HGP) were more likely to deny
requests for information, data, and materials than were other life scientists.8
Understanding the withholding of information, data, and materials may
be particularly important in genetics for a number of reasons. First, since
academic geneticists publish more articles in peer-reviewed journals, teach
more, and serve in more leadership roles in their university and discipline
than do their colleagues in other biomedical specialties, the sharing and
withholding practices of geneticists may have a disproportionate impact on
university policy, the behavior of junior faculty, and the training and socialization
of graduate students and postdoctoral fellows.11
Second, understanding the role of genetics in human disease is believed
to be important to the future of medicine.12
Clearly, the progress made in mapping and sequencing the human genome represents
a major step toward scientific breakthroughs in genetic-based diagnostics,
preventive technologies, and therapeutics. The rate of progress in realizing
these medical benefits may depend somewhat on the extent to which the results
of genetic investigations flow freely among scientists in the field.
There is scant empirical evidence regarding sharing and withholding
in academic genetics. For example, little is known about the extent to which
geneticists share and withhold information and how these behaviors have changed
over time. Nor do we know much about the reasons researchers withhold information,
data, or materials from other academicians and what impact this behavior has
on individual researchers or on the field of genetics as a whole. To address
these issues, we conducted a national study of data sharing and data withholding
in academic genetics, with a comparison group of other life sciences.