Article

A REVIEW ON MACROSCOPICAL, PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF CO�VULVULUS ARVE�SIS (FIELD BIDWEED)

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  • F-10 Focal Point. Industrial Area Derabassi
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Abstract

Convolvulus arvensis is a long lived deep rooted weed belongs to the family Convolvulaceae. It is commonly known as European bindweed, bindweed, creeping jenny, morning glory, and devil’s guts. It has at least 84 common names. Field bindweed is found in a wide range of habitats: orchards, vineyards, roadsides, ditch banks, cropland, steam banks, and lakeshores. Field bindweed begins growing in the late spring or early summer and may persist until the first frost. It is most likely confused with the Ipomoea spp., Calystegia spp., Dioscorea spp, Polygonum convolvulus L. It is very much difficult to differentiate between all these species. The plant contains Saponins, Alkaloids, and Polyphenolic compounds Flavonoids and Tannins. It has stimulant, anti-oxidant, anticancer and laxative effect. This review shows its identification, some of the isolated compounds and its biological activities.

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... Members of this family mainly contain phenolic, tropane alkaloids [2], flavanoids and coumarins [3].The largest genus of family Convolvulaceae is Convolvulus; it comprises 250 species present as trees, shrubs or herbs [4]. Many Convolvulus species are valuable ornamentals, medicinal and food crops [5]. They possess cytotoxic [6], antioxidant, anti-inflammatory and antiulcer activities [3]. ...
... Studies showed that the convolvulus species contains phenolics [174], saponins, steroids, alkaloids, proteins, lipids [175], polyphenolic compounds [5], flavonoid [11,176], coumarins [177,178], volatile oil, carbohydrates [179], tannins, cardiac glycosides [180,181], triterpenoids [182], lactones and amino acids [183]. ...
... Biological activities of Convolvulus species: Reviewing the previous literatures; we found that Convolvulus species possess various biological activities such as; cytotoxic activity, stimulating effects [175], antimicrobial activity [184], anticonvulsant activity, antioxidant activity [1,176,185], neuroprotective effect [186], antimicrobial activity [187,178], anti-inflammatory, anti-nociceptive, antipyretic activities [11], laxative effect [5], scavenging activity [169], antibacterial, antiulcer [177], antistress [177], antidysenteric, hypolipidaemic, larvicidal, anti-mosquito properties and useful as a memory enhancer [182], antidiarrhoeal effect [183], anti-cancer agents [188], anti-angiogenesis [172], CNS-depressant activity [189], antifeedant [182], antidiabetic activity [190] and inhibition of platelet aggregation [191]. ...
... Convolvulus is the largest genus of family Convolvulaceae; it contains 250 species present as herbs, trees, or shrubs [15]. Many Convolvulus species are valuable ornamentals, medicinal and food crops [16]. ...
... These plants are creeping or twining herbs or shrubs of various appearances and habits. Leaves are undivided or lobed, if parted mostly 1 of glabrous calyx, relatively big, not crowded, funnel-shaped, with entire, 5-angled or 5-plaited limb, and no regular colored stripes like those of Ipomoea [15]. These plants are mainly used in Saudi Arabia as folk medicine for treatment of ulcer diseases. ...
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Convolvulus austroaegyptiacus Abdallah & Sa’ad (CA) and Convolvulus pilosellifolius Desr. (CP) are commonly used in the Saudi Arabia folk medicine. They are potent in treating the ulcers and skin diseases. The lack of information about their biological activities led us to investigate the possible biological activities by determination of antibacterial and antioxidant activities of total ethanolic extracts and various fractions. Total flavonoid contents of the plants were determined by colorimetric method while total phenols were determined by using Folin-Ciocalteu method. In vitro antibacterial activity was studied against E. coli , P. aeruginosa , and B. subtilis , and the total antioxidant capacity was evaluated by radical scavenging method. IC 50 were found to be 21.81, 17.62, and 3.31 μ g/mL for CA , CP , and vitamin C, respectively, while the lowest MIC value of 0.25 mg/mL was recorded with CP extract against B. subtilis. Around 21 compounds are tentatively elucidated from both plants using rapid, simple, and high-resolution analytical technique for chemical profiling of natural compounds by direct analysis in real-time of flight-mass spectrometry, of which 17 were not isolated or reported previously.
... Moreover, its methanol extract induced a dose-dependent relaxation of rabbit's duodenal smooth muscle [25]. It possesses stimulatory, antioxidant, anti-cancer and laxative effects as well [26]. ...
... While CL is an important health problem in Mashhad (north-east of Iran), important limitations of existing drugs including their low efficacy, resistance, high price and unfavorable side effects worsen the situation. One strategy is to use the agents which are toxic for promastigote stage of parasite life and prevention from its infectivity for host cells [25][26][27][28][29][30][31][32][33][34]. Promastigote form is not a clinical relevant stage; however, it gives valuable information on the specificity of tested entity [52]. ...
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Background: Convolvulus arvensis L. (Convolvulaceae), bindweeds, is inhabitant to Iran and its proteoglycan mixture (PGM) has been reported to possess different biological activities. In the present study, we aimed to investigate different properties of PGM including anti-tumor, anti-angiogenesis and immunostimulatory activities. Methods: PGM was prepared from the roots of C. arvensis. Various cancer cell lines were treated with PGM and the cytotoxicity was assessed after 24 h of incubation using MTT assay. In addition, J774A.1 macrophages were stimulated with LPS (1 µg/mL) and then with PGM. Then, production of nitric oxide (NO) as a marker of inflammation was measured using Griess reagent. Moreover, PGM was subjected to cultivated Leishmania major promastigotes and leishmanicidal activity was determined using MTT assay. More importantly, human umbilical vein endothelial cells (HUVEC) cultured on matrigel basement matrix and tube formation after treatment with PGM was considered microscopically for the determination of angiogenesis. Results: Obtained results revealed that PGM significantly inhibited the formation of vascular-like tubes by HUVECs without any effect on their viability. Furthermore, PGM significantly exhibited leishmanicidal activity by the mechanism of suppressing L. major promastigotes developmental growth in vitro. However, PGM was shown to have no effect on the growth of cancer cells and production of NO by LPS-stimulated macrophages. Conclusions: The present study provides some new evidence on remarkable leishmanicidal and anti-angiogenic activities of PGM. These findings also afford the scientific basis for the use of C. arvensis as a candidate medicinal plant for further thoroughly phytochemical investigations toward discovering leishmanicidal and anti-angiogenic compounds.
... Indeed, phenolic are one of the most bioactive compounds (Kumar and Naraian, 2019). Convolvulus is one of the most important genus of the Convolvolacea family, it includes over than 250 species, present as herbs, shrubs and occasionally trees (Arora and Malhotra, 2011). (Elzaawely and Tawata, 2012) and antimicrobial proprieties, and a neuroprotective role (Al-Rifai et al., 2017;Azman et al., 2015;Bihaqi et al., 2009;Nacef et al., 2010;Tawaha et al., 2007). ...
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The composition of polyphenols, chlorophylls and carotenoids of eight extracts of Convolvulus althaeoides L. leaves, harvested in two different seasons, winter and spring, and extracted by hot extraction method using four solvents (dichloromethane, chloroform, ethyl acetate and ethanol) with increasing polarity, were evaluated along with their antioxidant and antifungal activities. Qualitative and quantitative variations were observed in the composition based on two different high performance liquid chromatography systems, liquid chromatography-photodiode array detection coupled to either atmospheric pressure chemical ionization mass spectrometry or to electrospray ionization mass spectrometry, permitting the identification of 22 polyphenols, 11 chlorophyll derivatives and 10 carotenoid compounds. Phenolic compounds were predominant in extracts from leaves collected in winter, whereas pigments were predominant in the spring collections. Antioxidant activities of the extracts were determined by DPPH radical scavenging method, revealing a half inhibition concentration (IC50) ranging from 0.1369 ± 0.0272 mg g⁻¹ to 0.432 ± 0.0018 mg g⁻¹, with no correlation to seasonal fluctuation. Concerning antifungal assays, ethyl acetate and ethanol extracts have been shown to be the most active against dermatophytes (T. rubrum, T. menthagrophytes, M. canis), with inhibiting percentages reaching 100% with 50 mg mL⁻¹. Moreover, ethyl acetate and ethanol extracts showed a maximum inhibition potential with minimum inhibitory/fungicidal concentrations ranging from 0.78-6.25 mg mL⁻¹ on Candida spp. cultures. The winter collect of these extracts showed an inhibitory effect of 90% on Candida albicans germ tubes formation, at a concentration of 3.1 mg mL⁻¹. In conclusion, seasonality seems to influence the quality and the quantity of natural substances from leaves of C. althaeoides L., which have major importance on the antioxidant and the antifungal effectiveness.
... Most of Convolvulus plants contain alkaloids (Nacef et al., 2010), anthocyanin (Cabrita, 2015), flavanoids and coumarins (Awaad et al., 2015;Sethiya et al., 2010). In addition, they possess many pharmacological activities including cytotoxic (Arora & Malhotra, 2011), antioxidant, antiinflammatory and antiulcer activities (Sethiya et al., 2010), used in treatment of coughs and asthma (Donia et al., 2011). Peptic ulcer is a common gastrointestinal disorder in modern era. ...
Article
Oral administration of the total alcohol extract of Convolvulus pilosellifolius Desr. (250 and 500 md/kg) showed potent anti-ulcerogenic activity in absolute ethanol-induced ulcer model in rats; it showed percent protection of control ulcer by 69.2 and 84.6%, respectively, while standard ranitidine (100 mg/kg) exhibited 46.2%. Bio-guided work leads to isolation of two novel compounds (1 and 2), which were identified through (1) H, (13) C NMR, HMPC, HMQC and DEPT as: methyl 2-(hydroxymethyl) octanoate, named as amanitate, and 16-amino-9,13-dimethyl-17-(prop-1-en-2-yl)-hexadecahydro-1H-cyclopenta[a] phenanthren-3-ol, named as asmatol. Both compounds (50 mg/kg) possessed anti-ulcerogenic activity with 95.4% and 55.84% protection, respectively. Two known compounds (3 and 4) were also isolated and identified through comparison with authentic samples and confirmed through different NMR techniques as kampeferol and quercetin. These compounds also showed anti-ulcerogenic activity with 78.38% and 5.38% protection, respectively. The cytoprotective mechanism explains the potent anti-ulcerogenic activity of the total alcohol extract and the isolated compounds. The extract was highly safe as the LD50 was more than 5000 mg/kg. These results were well supported by the sub-chronic toxicity study, as the extract (500 mg/kg) administrated orally to rats for 35 consecutive days showed no alteration in the liver and kidney functions. Copyright © 2016 John Wiley & Sons, Ltd.
... Phytochemical studies on the aerial parts of this plant showed the presence of various compounds such as saponins, terpinoids, steroids, tropane alkaloids (Pseudotropine, tropine, tropinone, meso-cuscohygrine, Hygrine, calystegine and atropine), flavonoids (Kaempferol, Quercetin and rutin), phenolic acids and different quantities of essential elements. In addition to that, the whole plant parts contain also starch, mucilage, fat and protein with different quantities depending on part that distributed [2]. Convolvulus arvensis was recorded to use traditionally as a laxative and diuretic plant in different worldwide. ...
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Objective: The aerial parts of convolvulus arvensis examined for their cytotoxicity and genotoxicity actions for two doses of four organic solvents fractions according to their polarity. Methods: The aerial parts of the crud plant were extracted with 80% aqueous ethanol and fractionated using petroleum ether, chloroform, ethyl acetate and n-butanol which were then examined on bone marrow of mice by measuring the mitotic index (MI) and chromosomal aberrations (CA) for two doses of the each fraction dissolved in DMSO and used cyclophosphamide as standard for positive control while DMSO only remain as negative control. Results: The results showed that the chloroform and n-butanol fractions give significant decrease in MI and increased CA for both doses. The petroleum ether in low doses didn't give any significant effect while the high dose had. The ethyl acetate fraction of low dose increased MI and decreased CA while the high dose gives the inverse action. Conclusion: The results could be explained due to different active constituent that present in each fraction mainly alkaloids, flavanoids and saponins for chloroform, ethyl acetate and petroleum ether respectively. For this reason it is possible that the plant extracts can have a therapeutic effect to destroy the cancerous cells. However, further studies on active components and their effects on cell divisions are needed.
... It is commonly known as European bindweed, bindweed, creeping jenny, morning glory, and devil's guts. It has at least 84 common names (Arora M and Malhotra M, 2011). ...
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The investigation was carried out to determine the qualitative and quantitative analysis of phytochemical screening and possible chemical components of C. arvensis aerial parts and roots by GC-MS. The aerial parts and roots showed the presence of as sugar, tannins, flavonoids, steroid, terpenoids and alkaloids. A total of 31 compounds, which were the major part of the extracts, were identified by matching mass spectra with a mass spectrum library (NIST 2.0 f). GC-MS analysis of acetone aerial parts extracts lead to identification of nine compounds while methanol aerial parts extract identification of seven compounds. Three compounds were identified from methanol roots extract. There were seven compounds identified from acetone roots extract and four compounds identified from aquatic roots extract.
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The phytochemical studies showed that Convolvulus arvensis contained alkaloids, phenolic compounds, flavonoids, carbohydrates, sugars, mucilage, sterols, resin. tannins, unsaturated sterols/triterpenes, lactones and proteins; while, scammonia contained scammonin resin, dihydroxy cinnamic acid, beta-methyl-esculetin, ipuranol, surcose, reducing sugar and starch. The previous pharmacological studies revealed that Convolvulus arvensis possessed cytotoxic, antioxidant, vasorelaxat, immunostimulant, epatoprotective, antibacterial, antidiarrhoeal and diuretic effect; while, Convolvulus scammonia sowed purgative , vasorelaxat, anti platelet aggregation, anticancer and cellular protective effects. This study will highlight the constituents and pharmacological effects of Convolvulus arvensis and Convolvulus scammonia.
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