The relationship between the results of a previous knowledge diagnostic exam (DE), the academic performance in biochemistry, and the way the students were admitted to the "Luis Razetti" Medical School in 2004-2005, was determined. The average grade obtained in the diagnostic exam was 10.2 ± 5.4 and had a Pearson correlation of 0.7 (P= 0.000) with the academic performance. It was found that students that were admitted to the UCV by a selection process have a better outcome in the diagnostic exam (10.7 ± 5.58 vs. 8.2 ± 4.6) and in the academic performance, compared to the students that were admitted by any of the admission agreements subscribed by the UCV. It was concluded that students that do not have the previous knowledge required have more probability to obtain low califications in biochemistry.