EEG PHOTIC DRIVING IN NEUROPSYCHIATRIC DISEASES IN
CHILDREN
V.V. Lazarev⁎, A. Pontes, M.A. Genofre, L.C. deAzevedo
Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
EEG driving responses to the intermittent photic stimulation can enhance
manifestation of latent oscillations. An individual's driving “profile” composed
of the amplitude spectra measured at various stimulation frequencies is
... [Show full abstract] supposed
to provide, in comparison with the spontaneous EEG spectrum, a more
comprehensive representation of the set of potential oscillators. In search for
latent EEG features of brain development and functional alterations in
neuropsychiatric diseases, photic driving at 11–17 fixed frequencies of 2–
24 Hz was studied in 57 normal subjects and 87 neurologic patients, aged 5–
18 years. In 12 non-visual brain areas in the normal group, the percentage of the
leads showing sharp driving peak response in the EEG spectra positively
correlated with the age, while in the occipital areas, the theta amplitude
maximum in the driving profile correlated with the age negatively. The
individual profiles replicated the shapes of the resting EEG spectra at higher
amplitude level with a maximum in the alpha band. There was a second profile
maximum in the theta band that was characteristic for younger children and preadolescents,
the latter did not have theta peak in the spontaneous spectra.
Twenty-two naïve patients with partial epilepsy showed higher percentage of the
driving occurrence in the non-visual areas than 49 treated patients. In 8 naïve
patients examined after 1–2 months of treatment with Carbamazepine, this
percentage decreased significantly in the alpha and beta bands. In 15 patients
suffering from migraine, there was a trend to the right-side driving prevalence.
Sixteen autistic children free of drug treatment, with relatively intact verbal and
intellectual functions, showed reduced right-side driving reactivity predominantly
in the alpha and beta bands, probably reflecting some deficit in the right
hemisphere activation.