A Double-edged Sword: Uric Acid and Neurological Disorders

Brain disorders & therapy 11/2013; 2(2):109. DOI: 10.4172/2168-975X.1000109
Source: PubMed


Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons because of its induction it impairs antioxidant capacity in the cell. High levels of UA, on the other hand, lead to an inflammatory response contributing to gout or neuroprotection. In this review, we summarize this biphasic function of uric acid and highlight potential therapeutic targets to treat UA-related neurological diseases.

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Available from: PubMed Central, Feb 20, 2014 · License: CC BY
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    • "This may be related to the multiple actions of uric acid. On the one hand, the soluble form of uric acid acts as an anti-oxidant, but causes oxidative stress when levels are reduced (Fang et al., 2013). On the other hand, at high concentration, monosodium (MSU) crystals are formed, that can trigger the inflammatory response that can lead to an increased excitability (Vezzani et al., 2012). "
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