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Human basophil degranulation triggered by very dilute antiserum against IgE

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Abstract

When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. The latter can be demonstrated at dilutions of anti-IgE that range from 1 x 10(2) to 1 x 10(120); over that range, there are successive peaks of degranulation from 40 to 60% of the basophils, despite the calculated absence of any anti-IgE molecules at the highest dilutions. Since dilutions need to be accompanied by vigorous shaking for the effects to be observed, transmission of the biological information could be related to the molecular organization of water
© 1988Nature Publishing Group
© 1988Nature Publishing Group
© 1988Nature Publishing Group
... Ямс ковой и других не получали никакого отклика [19]. В последние годы все больше ученых обращаются к проблеме эффекта СМД, расширился спектр био логических объектов, на которых про водятся эти исследования, возросло число веществ и физических факторов, у которых обнаружена активность в СМД [5,26]. Постоянно происходит на копление, обобщение и систематиза ция полученных данных [4,5]. ...
... К настоящему времени накоплен значи тельный экспериментальный материал, свидетельствующий о биологических эффектах лекарственных препаратов в СМД [2,5,8,26]. Как и для других ве ществ, действующих в области СМД, для компонентов лекарственных препа ратов, характерен полимодальный ха рактер зависимости доза/эффект. ...
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Идейным лидером использования сверхмалых доз (СМД) в медицине можно считать Парацельса. Практическое использование СМД веществ во врачебной практике было предложено в 1790 г.Самуилом Ганеманом. Наряду с принципом similia similibus curantur (подобное лечится подобным), идея СМД легла в основу метода гомеопатической терапии (греч. homoios — подобный, pathos — страдание). Именно из-за сверхмалого количества действующего вещества долгие годы неоспоримые клинические результаты терапии гомеопатическими препаратами невозможно было объяснить с научной точки зрения. Это было основным препятствием на пути признания гомеопатии академической наукой и медициной. На сегодняшний день изучение эффектов СМД является одним из передовых рубежей фармакологии и фармакотерапии.
... It was emphasized that "the problem of reduced reproducibility of nonthermal (that is, nonheating, not leading to an increase in the temperature of living tissue-S.A. and L.B.) effects is important; in the presence of many generally recognized irreproducibility factors, its nature has not yet been studied" [26, p. 578]. Although the foregoing referred to small effects in magnetobiology, this is also important in the interpretation of low-dose phenomena [8,10], especially in the study of high and ultrahigh dilutions of aqueous biosolutions [11,13,31]. We propose [17] to attribute the source of the often implemented, but still not understood, problem of the nonrepeatability of biological experiments and tests (see the discussion in [32,33]) to the external, uncontrolled in these experiments, electromagnetic (microwave) radiation from the ionosphere, which we proposed for accounting. ...
Article
The results of a study on the mechanisms of the influence of an increased level of microwave radiation on the growth of infectious, primarily viral, diseases in the environment are presented. This is the radiation of the earth's ionosphere, which reached its maximum in the late 1980s-early 2000s, following an increase in the level of solar activity since the 17th century. Over the past 30 years, the anthropogenic electromagnetic background has increased 100 times due to the development of cellular mobile communications and computerization. The predicted interaction of natural and anthropogenic sources of microwaves sharply increases their negative impact on the ecological situation. Of particular concern is the active spread in recent years of the new 5G communication standard; in the future, it is the development of the most dangerous millimeter range in our country. Energy from the environment in the microwave range can cause "unexpected behavior" in the DNA of viruses. Clarifications to the recommendations of experts on the protection of the population with the help of electromagnetic shielding, obtained in the framework of supramolecular physics of the environment, are proposed.
... In Portugal, just to refer some examples, the writer Camilo Castelo Branco (1825-1890) 52 refers to it as the method for transforming the ocean in a useful medicine with ten drops of a poison, and the famous medicine doctor Sousa Martins (1843-1897), "explained" that "a homeopathic chicken soup" can be made from the shadow of a chicken on hot water. Besides the incredible amount of studies that failed to show the effects of homeopathy or are inconclusive, and the recent approaches based in the hormesis effect, it is relevant, due to its "pathological science" signature, the 1988 article of Jacques Benveniste , published in Nature, 53 and dismissed as erroneous due to unintentional bias of measurements and bad control. 54 This work, that promotes the "water memory theory", has more than 950 citations, a reasonable part still using it to support homeopathy. ...
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ResumoOs dados biográficos sobre cientistas, e em particular de químicos e físicos, podem ser usados como elemento motivador dos estudantes e público assim como um instrumento humanizador da ciência e demonstrativo da forma como esta funciona na prática. A dimensão humana da ciência emerge naturalmente da análise de apontamentos biográficos que enfatizem os dilemas e os sucessos e fracassos dos cientistas. Os episódios históricos e as atitudes e acções dos cientistas mostram como funciona a ciência e dão aos estudantes e público a possibilidade de reflectirem sobre a ciência e a sua humanidade, assim como de desenvolverem a capacidade de desconfiar do anacronismo, da pseudo-ciência, da ciência patológica e da fraude científica, para melhor apreciarem e entenderem o desenvolvimento da ciência. Começando com uma breve revisão dos sintomas e critérios propostos na literatura para distinguir desvios anormais, neste trabalho são analisados alguns casos de produção de ciência patológica nos campos da química e da física, procurando, a partir destes, evidenciar caminhos pedagógicos que fomentem o espírito crítico dos estudantes e do público. Palavras-chave: Biografias de cientistas, estratégias pedagógicas, humanidade da ciência, pseudo-ciência, ciência patológica. Abstract Biographical data about scientists, and in particular about chemists and physicists, can be used for engaging students and the public, humanizing the science image, and for demonstrating how it works in the practice. The human dimension of science emerges naturally from the analysis of biographical aspects that emphasize the dilemmas and the successes and failures of scientists. The historical episodes and the attitudes and actions of scientists show how science works and offer students and public the opportunity to reflect about science and its humanity, as well as to develop the capacity to distrust anachronism, pseudo-science, pathological science, and scientific fraud in order to better appreciate and understand the action and development of science. Starting with a brief review of the symptoms and criteria proposed in the literature to distinguish deviations from normal science, this work analyzes some cases of production of pathological science, focusing on chemistry and physics, seeking pedagogical paths that foster the critical spirit of students and the public.Keywords: Biographies of scientists, pedagogical strategies, the humanity of science, pseudo-science, pathological science.
... A very publicized controversy about the memory of water began in 1988 between immunologist Jacques Benveniste from one side and the editors of the prestigious magazine Nature on the other [Editorial 1998;Davenas 1988]. The first claimed to have found experimental evidence of its existence, but the magazine agreed to publish its article only on condition that its results were submitted to verification by an independent commission. ...
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FOREWORD 2019 In this edition, the theme of ozone has been updated with a much more complete review, published in the Rev. Cub. Fis. in 2017. Also appears an article on Ayurveda and its comparison with contemporary scientific medicine, due to some attempts to introduce Ayurveda in our country, as discussed in the article. For the rest, the 2017 prologue below remains valid. Pyramidal therapies and magnetotherapy may have lost ground, but homeopathy and ozone therapy are still maintained, and even such absurd and unproven medications such as Vimang are still sold in pharmacies at the time of writing these lines. We hope this edition has as good reception as the previous one. The author
... A very publicized controversy about the memory of water began in 1988 between immunologist Jacques Benveniste from one side and the editors of the prestigious magazine Nature on the other [Editorial 1998;Davenas 1988]. The first claimed to have found experimental evidence of its existence, but the magazine agreed to publish its article only on condition that its results were submitted to verification by an independent commission. ...
Book
Full-text available
FOREWORD 2019 In this edition, the theme of ozone has been updated with a much more complete review, published in the Rev. Cub. Fis. in 2017. Also appears an article on Ayurveda and its comparison with contemporary scientific medicine, due to some attempts to introduce Ayurveda in our country, as discussed in the article. For the rest, the 2017 prologue below remains valid. Pyramidal therapies and magnetotherapy may have lost ground, but homeopathy and ozone therapy are still maintained, and even such absurd and unproven medications such as Vimang are still sold in pharmacies at the time of writing these lines. We hope this edition has as good reception as the previous one. The author
... A very publicized controversy about the memory of water began in 1988 between immunologist Jacques Benveniste from one side and the editors of the prestigious magazine Nature on the other [Editorial 1998;Davenas 1988]. The first claimed to have found experimental evidence of its existence, but the magazine agreed to publish its article only on condition that its results were submitted to verification by an independent commission. ...
Book
Full-text available
FOREWORD 2019 In this edition, the theme of ozone has been updated with a much more complete review, published in the Rev. Cub. Fis. in 2017. Also appears an article on Ayurveda and its comparison with contemporary scientific medicine, due to some attempts to introduce Ayurveda in our country, as discussed in the article. For the rest, the 2017 prologue below remains valid. Pyramidal therapies and magnetotherapy may have lost ground, but homeopathy and ozone therapy are still maintained, and even such absurd and unproven medications such as Vimang are still sold in pharmacies at the time of writing these lines. We hope this edition has as good reception as the previous spanish one. The author
... Una controversia muy publicitada acerca de la memoria del agua se inició en 1988 entre el inmunólogo Jacques Benveniste por una parte y los editores de la prestigiosa revista Nature por la otra [Editorial 1998;Davenas 1988]. El primero alegó haber encontrado evidencias experimentales de su existencia, pero la revista aceptó publicar su artículo só-lo a condición de que sus resultados fueran sometidos a verificación por una comisión independiente. ...
Book
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PRÓLOGO DE NOV. 2019 En esta edición se ha actualizado el tema del ozono con una revisión mucho más completa, publicada en la Rev. Cub. Fis. en 2017. También se ha añadido un artículo sobre el ayurveda y su comparación la medicina científica contemporánea, a razón de algunos intentos de introducir el ayurveda en nuestro país, como se comenta en el artículo. Por lo demás, el prólogo de 2017 a continuación sigue siendo válido. Quizás las terapias piramidales y la magnetoterapia hayan perdido terreno, pero la homeopatía y la ozonoterapia aún se mantienen, e incluso medicamentos tan absurdos e indemostrados como el Vimang aún se venden en las farmacias al momento de escribir estas líneas. Esperamos que esta edición tenga tan buena acogida como la anterior. El autor
... Another puzzle in science is the ability of molecules of water for exchanging information with DNAs and storing their information [16], [17], [18]. The chemical structure of water (H 2 O) is very simple and has no ability to store information. ...
Article
Recently, some scientists from NASA have claimed that there may be a black hole like structure at the centre of the earth. We show that the existence of life on the earth may be a reason that this black hole like object is a black brane that has been formed from biological materials like DNA. Size of this DNA black brane is 109 times longer than the size of the earth's core and compacted interior it. By compacting this long object, a curved space-time emerges, and some properties of black holes emerge. This structure is the main cause of the emergence of the large temperature of the core, magnetic field around the earth and gravitational field for moving around the sun. Also, this structure produces some waves which act like topoisomerase in biology and read the information on DNAs. However, on the four-dimensional manifold, DNAs are contracted at least four times around various axis's and waves of earth couldn't read their information. While, by adding extra dimensions on 4 +n-dimensional manifold, the separation distance between particles increases and all of the information could be recovered by waves. For this reason, each DNA has two parts which one can be seen on the four-dimensional universe, and another one has existed in extra dimensions, and only it's e_ects is observed. This dark part of DNA called as a dark DNA in an extra dimension. These dark DNAs not only exchange information with DNAs but also are connected with some of the molecules of water and helps them to store information and have memory. Thus, the earth is the biggest system of telecommunication which connects DNAs, dark DNAs and molecules of water.
... In other words, he claimed to have definitively shown through his experiment the effectiveness of the homeopathic high potencies [3]. ...
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