Article

Activated DDR1 increases RS cell survival

Blood (Impact Factor: 10.45). 12/2013; 122(26):4152-4. DOI: 10.1182/blood-2013-11-534123
Source: PubMed

ABSTRACT

In this issue of Blood, Cader et al show that tumor microenvironment promotes Epstein-Barr virus (EBV)-driven lymphomagenesis in Hodgkin lymphoma by a novel pathway involving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated by collagen(s) and contributes to the survival of Reed-Sternberg (RS) cells.

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