Article

Photo-crosslinkable PEG-Based Microribbons for Forming 3D Macroporous Scaffolds with Decoupled Niche Properties

Advanced Materials (Impact Factor: 17.49). 03/2014; 26(11). DOI: 10.1002/adma.201304805
Source: PubMed

ABSTRACT

PEG-based microribbons are designed and fabricated as building blocks for constructing a 3D cell niche with independently tunable biochemical, mechanical, and topographical cues. This platform supports direct cell encapsulation, allows spatial patterning of biochemical cues, and may provide a valuable tool for facilitating the analyses of how interactive niche signaling regulates cell fate in three dimensions.

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Available from: Li-Hsin Han, Aug 15, 2014
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    • "-Linking and/or Bioconjugation Microribbons of PEG-based hydrogels have recently been introduced as interesting building blocks for the construction of 3-dimensional cell niches with independently tunable biochemical, mechanical, and topographical properties[102]. These PEG-based materials were build up from 8-armed PEG macromers and two different macromers were presented that contained different combinations of two types of chemically different functional groups in a macromer, namely PEG-(N-hydroxysuccinimide(NHS)) 4 -(methacrylate(MA)) 4 and PEG-(NHS) 4 -(maleimide) 4 . "
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    ABSTRACT: Contemporary biomaterials are expected to provide tailored mechanical, biological and structural cues to encapsulated or invading cells in regenerative applications. In addition, the degradative properties of the material also have to be adjustable to the desired application. Oligo- or polymeric building blocks that can be further cross-linked into hydrogel networks, here addressed as macromers, appear as the prime option to assemble gels with the necessary degrees of freedom in the adjustment of the mentioned key parameters. Recent developments in the design of multi-functional macromers with two or more chemically different types of functionalities are summarized and discussed in this review illustrating recent trends in the development of advanced hydrogel building blocks for regenerative applications.
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