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Weight loss and lipid-lowering efficacy of a low carbohydrate, calorie restricted
diet intervention on postmenopausal breast cancer patients
Amy K. Krie, MD,1Krista N. Bohlen, PharmD,1,2Cheryl Ageton, RN,1,2Heidi Nickles, MS,1,2
Daniel Norfolk, RN,1,2BSN,1,2Julie Kittelsrud, RN, C-NP,2Reggie Thomes, BS,2Adam Fahrendorf, BA,2Jessica Muth, RD, LD,1
Luis A. Rojas-Espaillat, MD,1Gareth E. Davies, PhD2and Yueshan Hu, PhD,2
1Avera Cancer Institute, Sioux Falls, SD, 2Avera Research Institute, Sioux Falls, SD
San Antonio Breast Cancer Symposium – Cancer Therapy and Research Center at UT Health Science Center – December 10-14, 2013
1.Ewertz, M, M-B Jensen, K Gunnarsdottir, et al. Effect of obesity on prognosis after early-stage
breast cancer. J Clin Oncol 29:25-31, 2011.
2.Kraus, WE, Houmard, JA, Duscha,BD, et al. Effects of the Amount and Intensity of Exercise on
Plasma Lipoproteins. N Engl J Med. 347:1483-1492, 3003.
3.Patnaik, JL, Byers, T, DiGuiseppi, C et al. Cardiovascular disease competes with breast cancer as
the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort
study. Breast Cancer Res. 13(3): R64, 2011.
•To assess if a carbohydrate restricted, low calorie dietary intervention is
feasible in breast cancer survivors.
•To evaluate the efficacy of the dietary intervention on weight loss.
•To evaluate the efficacy of the dietary intervention on improving lipid
Obesity and weight gain are associated with higher rates of breast
cancer recurrence and increased mortality.1Cardiovascular disease is
a leading cause of death in breast cancer survivors.3 The purpose of
our study was to see if a low carbohydrate, calorie restricted dietary
intervention could be implemented in a group of obese postmenopausal
breast cancer survivors to achieve weight loss and improved lipid
• A aggressive dietary intervention is feasible in postmenopausal
breast cancer survivors.
•A low carbohydrate, calorie restricted dietary intervention resulted in
significant weight loss and improvement in lipid profile through
lowering of triglyceride levels.
•Additional studies with a larger sample size would be beneficial as a
potential strategy for cardiovascular risk reduction and improved
survival in breast cancer survivors.
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•Average weight loss spanned over 23.8 weeks (5 to 59 weeks).
•Compared with the mean body weight prior to the dietary
intervention, the mean body weight was reduced by 19.9% (43.7
•Mean body fat percentage was reduced by 6.86%.
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Blood triglyeride level (mg/dL)
Diet intervention time (week)
Early Stage ER+ breast cancer survivor
Completed surgery & adjuvant
No underlying inflammatory condition
No treatment for diabetes
57 years (42-68)
220 lbs (171-300)
23 weeks (5-59)Weight Loss Period
<40 gm carbs,
Labs every 2
weeks x 12
•The mean total cholesterol level was decreased by 9.5% with the
dietary intervention (p=0.00498).
•The dietary intervention significantly decreased the patients’ blood
triglyceride level by 33.8% (p=0.00013).
•Weight loss averaged 5.4 pounds in week one and 2.14 pounds
per week in weeks 2-19.
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Average body weight (LB)
Ideal Protein diet intervention time (week)
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Diet intervention time (week)
Total cholesterol level (mg/dL)